Models, Molecules and Mechanisms in Biogerontology: Physiological Abnormalities, Diseases and Interventions

by Pramod C. Rath

Overview

This book examines the basic cellular and molecular mechanisms associated with aging. It comprehensively describes the genetic, epigenetic, biochemical and metabolic regulation of aging, as well as some important age-related diseases. Divided into two major sections, it takes readers through the various aspects of aging in a story-like manner and suggests various interventions for healthy aging, such as dietary restriction, regular exercise, nutrition and maintaining a balanced and a non-stressful lifestyle. It describes the implications of aging on the nervous system, metabolism, immunity and stem cells as well as care for the elderly. The book is an ideal companion for both new and established researchers in the field and is also useful for educators, clinicians and policy makers.

Product Details

ISBN-13:	9789811335846
Publisher:	Springer Nature Singapore
Publication date:	07/31/2019
Edition description:	1st ed. 2019
Pages:	436
Product dimensions:	6.10(w) x 9.25(h) x (d)

About the Author

Pramod C. Rath is a Professor of Molecular Biology at the School of Life Sciences, Jawaharlal Nehru University, New Delhi. He received his Ph. D. in Zoology (Biochemistry) in 1988 from the Banaras Hindu University, Varanasi on the topic ‘gene expression during aging’ under the supervision of Prof. M. S. Kanungo, who started research on ‘biology of aging’ in India. He completed his post-doctoral research at the Institute for Molecular Biology I, University of Zurich, Switzerland with Prof. Charles Weissmann, a well-known molecular biologist.

He has 27 years of teaching and research experience, having mentored 18 Ph. D. and 4 M. Phil. students. He has published his research in respected international journals, such as Ageing Research Reviews, Molecular Neurobiology, Journal of Molecular Neuroscience, International Journal of Developmental Neuroscience, RNA Biology, PLoS ONE, International Journal of Biological Macromolecules, Molecular Biology Reports, Journal of Biosciences, Biochemical Biophysical Research Communications, Biochimica Biophysica Acta, FEBS Letters, Journal of Clinical Immunology etc. He has published a Springer book, titled 'Topics in Biomedical Gerontology'.

He teaches molecular biology, molecular genetics & genetic engineering and cell signaling to master’s and Ph.D. students. Research in his laboratory is focused on cytokines; transcription factors; cell signaling and diseases; genomic biology of repetitive DNA and noncoding RNA; bone marrow stem cells and molecular aging in mammals. He has received numerous awards and fellowships and has been the Vice-President of the Association of Gerontology (India), Acting Dean at the School of Life Sciences. He is a member of several national academic and scientific committees.

Table of Contents

I. Alterations in Nervous System, Genes, Hormones and Immunity during Aging

1. Neurological Problems of the Elderly

2. Molecular marker and therapeutic regimen for neurodegenerative diseases

3. Neurodegeneration during Aging: Role of Oxidative Stress through Epigenetic Modifications

4. Polyglucosan Bodies in Aged Brain and Neurodegeneration: Cause or Consequence?

5. Overview of effect of Tachykinin Neuropeptides and 17β Estradiol in Aging Brain

6. Signaling of Nociceptors and Pain Perception: Impact of age

7. Association between Ageing and REM sleep loss: Noradrenaline acting as a mediator

8. Age related changes in the human retina: a role for oxidative stress

9. Mitophagy, Diseases and Aging

10. Genetics, Ageing and Human Health

11. Genetic Syndromes and Aging

12. Role of Stress and Hormones of the Hypothalamic-Pituitary-Adrenal (HPA) Axis in Aging

13. Sex Steroids, Cognate Receptors and Aging

14. Immunosenesence, Inflammaging and their implications for Cancer and Anemia

15. Bone Marrow Stem Cells, Aging and Age-related Diseases

II. Interventions for Healthy Aging

16. Infantile radiation and Aging Stresses: Effects of Calorie and Dietary Restrictions

17. Mechanisms and Late Life Intervention of Aging

18. Healthy Ageing and Cancer in Humans

19. Care of older persons in India: scope of policy and technology tools

20. Nutrition for elderly