Microsomes, Drug Oxidations and Chemical Carcinogenesis V2

by Minor Coon (Editor)

Overview

Microsomes, Drug Oxidations, and Chemical Carcinogenesis, Volume II, documents the proceedings of the 4th International Symposium on Microsomes and Drug Oxidations held in Ann Arbor, July 1979. The symposium reviewed progress in the understanding of scientific and biomedical problems from a biochemical, biophysical, pharmacological, and toxicological perspective. Volume I contained 117 contributions made by researchers at the symposium, which were organized into three sections (Sections I-III). This second volume contains 122 contributions, divided into four sections (Sections IV-VII). The papers on Section IV examine the metabolic fate of oxygenated compounds. Section V provides studies on microsomal enzymes and lipid metabolism. Section VI includes papers on microsomal enzymes and toxicity of foreign compounds. Section VII covers microsomal enzymes and chemical mutagenesis and carcinogenesis. This book seeks to aid future progress in understanding the complexities of metabolic transformations by these versatile enzyme systems that act on physiologically important lipids as well as on a wide array of foreign substances, including drugs, anesthetics, industrial chemicals, food additives, pesticides, carcinogens, and nonnutrient dietary chemicals.

Product Details

ISBN-13:	9780323143875
Publisher:	Elsevier Science
Publication date:	12/02/2012
Sold by:	Barnes & Noble
Format:	eBook
Pages:	655
File size:	11 MB
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Table of Contents

Section IV Metabolic Fate of Oxygenated Compounds

Rate-Limiting Factors in Xenobiotic Metabolism by Cytochome P-450, Sulphotransferase, and Glucuronyl Transferase

Epoxide Hydratase

Kinetic Studies on Mechanism and Substrate Specificity of the Microsomal Flavin-Containing Monooxygenase

Epoxide Hydratase and its Membrane Environment

Interindividual Variations of Epoxide Hydratase Activity in Human Liver and Lung Biopsies, Lymphocytes and Fibroblast Cultures

Extramicrosomal Epoxide Hydration

Metabolism of Benzo(a)pyrene by Liposomes containing Purified Microsomal Drug-Metabolizing Enzymes

Comparison of Glutathione S-Transferases from Rat Tissues with the Activity in Human Placenta

Formation, Metabolism, and Excretion of Conjugates of Paracetamol

Subcellular Localization of Glutathione S-Transferase Activity in Rat Liver

Biliary Metabolites of Benzo(a)pyrene 4,5-Oxide in the Rat

Hepatic and Extrahepatic Glutathione S-Transferase Activities in Vitamin A Deficiency

Pulmonary Metabolism and Excretion of Arene Oxides

Metabolism of Arylamines: Evidence for Common Genetic Control of Arylhydroxamic Acid Acyltransferase (AHAT) and Genetically Polymorphic N-Acetyltransferase (NAT) of Rabbit Liver

Partial Purification of Glutathione (GSH)-S-Aryl- and Epodixe Transferase(s) of Trypanosoma Cruzi

Purification and Properties of UDP-Glucuronyltransferase from Rabbit Liver Microsomes

Section V Microsomal Enzymes and Lipid Metabolism

Cholesterol 7a-Hydroxylase in Rat Liver Microsomes—Characteristics, Solubilization, Resolution, and Substrate Specificity

Laurate Hydroxylation and Drug Metabolism in Pig Liver and Kidney Microsomes and in Reconstituted Systems from Pig Liver and Kidney

Product Specificity and Regulation of Two Laurate Hydroxylases in Higher Plants

Effect of Phenobarbital on Triglyceride Metabolism in the Rat

?- and (?-1)-Hydroxylation of Fatty Acids in Rabbit Intestinal Mucosa Microsomes

The Role of Cytochrome b5 in the Liver Microsomal Elongation of Fatty Acids

Evidence for Different Hepatic Monooxygenases in (?-1)- and ?-Hydroxylation of Prostaglandins

Effect of Inducing Agents and Cytochrome P-450 Inhibitors on Laurate Hydroxylase Activities in Rat Liver Microsomes

Steroid Hydroxylases in Liver Microsomes and Mitochondria

C-21 and 6a-Hydroxylation of Progesterone by Solubilized Rabbit Hepatic Microsomal Fractions: Nonobligatory Requirement for Cytochrome P-450

Microsomal Lipid Peroxidation: Catalysis, Effects, and Inhibition by Cytosolic Protein

Cytochrome P-450-Containing Monooxygenase System of Yeast Microsomes, Properties and Role in Sterol Biosynthesis

Studies on Liver and Kidney Drug and Lauric Acid Monooxygenases in Both Microsomal and Reconstituted Systems

Lipid Peroxidation induced by Glutathione Depletion

Metabolism of Juvenile Hormone (JH) Mimics by a Reconstituted Rat Liver Cytochrome P-450 Preparation

Section VI Microsomal Enzymes and Toxicity of Foreign Compounds

An overview of the Role of Microsomal Enzymes in the Formation of Toxic Metabolites

Microsomal Enzymes and the Toxicity of Thiono-Sulphur Compounds

The Ah Locus, Genetic Differences in Toxic and Tumorigenic Response to Foreign Compounds

Comparison of Caffeine Metabolism by Perfused Rat Liver and Isolated Microsomes

Rhythmic Response of the Hepatic 2- and 4-Biphenyl Hydroxylase in Rats to Drugs Upon Intermittent Treatment

Functional Changes of Hepatic Endoplasmic Reticulum by Adverse Drug Treatment

A Procedure for Isolation of Rabbit Pulmonary Epithelial Cells for Study of Foreign Compound Metabolism

The Formation of Amphetamine Metabolic Intermediate Complexes with CytoChrome P-450 in Microsomes and Intact Tissues

Comparative Aspects of Hepatic Monooxygenase Induction in Rat and Rainbow Trout by Several PCB Isomers

Genetic and Environmental Influences on Tolbutamide Metabolism

Ethchlorvynol: Potential of Metabolites for Adverse Effects in Man

Irreversible Binding of 6-Thiopurine to Rat Hepatic Microsomal Proteins In Vitro and In Vivo

Activation of a Proestrogen—Methoxychlor (DDT Analog)—by Hepatic Monooxygenase

Effects of Some Flame Retardants on the Liver Microsomal Enzyme Systems

The Development of Hepatic Mixed-Function Oxidases—Warfarin Metabolism as a Probe

Loss and Recovery of Hepatic Monooxygenase Activities After the Administration of Allylisopropylacetamide (AIA) to Mice

Metabolism of Fluroxene and Analogous Fluorinated Ether Anesthetics by Highly Purified Cytochromes P-450 and the Associated Enzyme Destruction

Evaluation of 4-Formylaminoantipyrine and other N-Demethylated Products of Aminopyrine in Hepatic Microsomes by HPLC

The Effect of Selenium and Vitamin E Deficiency on the Toxicity of Nitrofurantoin in the Chick

The Reductive Metabolism of Carbon Tetrachloride in Reconstituted Monooxygenase Systems

Oxidative Bioactivation of Haloforms into Hepatotoxins

Effects of Isoniazid Metabolites on the Rate of Hepatic Microsomal Defluorination of Volatile Fluorinated Ether Anesthetics

Effects of Indole Derivatives on Monooxygenase Activity in Rabbit Liver Microsomes

Coincident Induction of Cytochrome P-450 and Phenol Red Conjugation in Cultured Chick Embryo Hepatocytes: Effects of Cobaltous and Manganous Ions

Benzene Metabolism and Toxicity in CD-1, C57/B6, and DBA/2N Mice

Hepatotoxicity Due to Tetrachlorodibenzo(p)dioxin Depends Upon AHH Responsiveness and Nonhemoprotein Iron

The Mechanism of Cytochrome P-450-Mediated Cytotoxicity Studied with Isolated Hepatocytes Exposed to Bromobenzene

The Influence of the Nutritional State of Rates of p-Nitroanisole O-Demethylation and p-Nitrophenol Conjugation in Perfused Rat Livers

Acute Decline of Hepatic Microsomal Monooxygenase Activity and Other Properties by Morphine Sulfate

Substituent Effects on Toxicity and Covalent Binding of Bromobenzene Derivatives

Hepatic Microsomal Epoxidation of Bromobenzene to Phenols and its Toxicological Implication

Toxicity of 2-Chlorobenzylidene Malononitrile and Hepatic Microsomal Mixed Function Oxidase System

Alteration of Microsomal Monooxygenase Activities by Cobalt Pretreatment of Mice

Characteristics of the Microsomal and Mitochondrial Deamination of Benzylamine

Oxidation of N-Hydroxy-Amphetamine and -Phentermine by Active Oxygen

N-Methylcarbazole Metabolism: A Probe for Characterizing the Multiple Forms of Cytochrome P-450

Increased Activity of the Pentose Pathway after Administration of trans-Stilbene Oxide

Interactions Between Energy Metabolism and Mixed-Function Oxidation in Perfused Rat Liver

Evidence for More Than One Form of Cytochrome P-450 in Hepatic Microsomal Fractions of Human Liver Samples

The In Vitro Metabolism of 3-Acetylpyridine, 3-Acetylpyridine-N-Oxide, and 1-(-3-Pyridyl)-Ethanol

Studies on Sex Differences in the O-Dealkylation Activities of 7-Hydroxycoumarin O-Alkyl Derivatives in Liver Microsomes of Rats

Augmentation by Hematin of Rates of Benzo(a)pyrene Hydroxylation: the Possible involvement of Cytochrome P-450

Multiplicity of NADPH- and NADH-Supported N- and O-Dealkylating Systems of Hepatic Microsomes

4-Chlorobiphenyl Hydroxylase: a Monooxygenase Preferentially Induced by 3-Methlcholanthrene

NADH- and NADPH-Dependent Reduction of Indicine N-Oxide by Microsomal Cytochrome P-450

Metabolism and Irreversible Binding of Phencyclidine by Rabbit Lung and Liver Microsomes

Cleavage of Vicinal Diols by Liver Microsomes

Characterization of the Form of P-450 Induced by Methylenedioxy Compounds in Rats and Mice

Interaction of the Enzyme Inducer, HOE 17,879, with Microsomal Enzyme Systems

Relation Between In Vitro Alteration by Allyl Compounds and Forms of Cytochrome P-450

The Rapid Activation of P-450-Mediated Metabolism by Corticosteroids

Metabolism In Vitro of Capsaicin, a Pungent Principle of Red Pepper, with Rat Liver Homogenates

Section VII Microsomal Enzymes and Chemical Mutagenesis and Carcinogenesis

Metabolism of Benzo(a)pyrene and Oncogenic Transformation of C3H/10T1/2 Mouse Embryo Fibroblasts

An Overview of the Salmonella Mutagenicity Test

Bay-Region Activation of Polycyclic Aromatic Hydrocarbons to Ultimate Mutagens and Carcinogens

Biotransformation of Benzo(a)pyrene to DNA-Binding Products by Isolated Hepatocytes

Catalytic Activity and Stereospecificity of Phenobarbital-Inducible and 5,6,-Benzoflavone-Inducible Isozymes of Liver Microsomal Cytochrome P-450 in the Oxygenation of Benzo(a)pyrene and trans-7,8-Dihydroxy-7,8-Dihydrobenzo(a)pyrene

Metabolism of Nitrosamines: an Overview

Species Differences in Microsomal Activation of Mutagens and Carcinogens, with Special Reference to New Potent Mutagens from Pyrolysates of Amino Acids and Proteins

Microsomes and Drug Oxidations: Perspectives and Challenges

Catalytic Properties of Microsomal and Purified Epoxide Hydrolase Toward K-Region Arene Oxides

Drug-Metabolizing Systems in the Liver of the Northern Pike, Esox Lucius

Dietary Protein and Mixed Function Oxidase Activity

The Metabolism of 1,2-Disubstituted Hydrazines in Isolated Hepatocytes

Mutagenicity and Metabolism of Cyclopenta(cd)pyrene

Some Characteristics of the Drug-Metabolizing Enzymes in Isolated Hepatic Nuclei

Microsomal Metabolism of Diallylnitrosamine

Mutants of Cultured Hepatoma Cells Deficient in Aryl Hydrocarbon Hydroxylase

Qualitative and Quantitative Studies of DNA-Binding Metabolites of Benzo(a)pyrene by Fluorescence Spectroscopy

Use of the Ames Assay for Studying Factors Affecting the Activation of 2-Aminoanthracene to Mutagenic Metabolites

Cytochrome P-450 Form 4, a Major Determinant of 2-Aminoanthracene Mutagenesis

Rat Hepatocytes of in Primary Monolayer Culture: a Tool for Investigating the Regulation of Carcinogen Metabolism

The Metabolism of 3- and 9-Hydroxybenzo(a)pyrene by Rat Liver Microsomal Fractions

Effect of Chronic Ethanol Consumption on Microsomal Enzymes: Potential Relationship to Chemical Mutagenesis and Carcinogenesis

Characterization of the Cytochrome P-450-Containing Mixed Function Oxidase System of Rat Colon

Induction of N- and C-Hydroxylations of 2-Acetylaminofluorene in Rat Hyperplastic Liver Nodules and Hepatomas

Multiple Activation Pathways of 7,12-Dimethylbenz(a)anthracene

Influence of Modifiers of MFO Activity on the In Vitro Metabolism of Cyclic Nitrosamines

Autocatalyzed Covalent Binding of 3H(-)t-7,8-Diol Benzo(a)pyrene to Mixed-Function Oxidase Enzymes and DNA: the Role of Epoxide Hydratase

Regulation of DNA Modification by Selective Conjugation of Benzo(a)pyrene Metabolites

Metabolism of Benzo(a)pyrene in Little Skate Mixed-Function Oxidase Systems

Inducibility of the Metabolism of Benzo(a)pyrene by Polychlorinated Biphenyls (PCBs) in Liver and Lung Microsomal Preparations from Rats and Rabbits

Covalent Binding of Vinyl Chloride Metabolites In Vitro: Roles of Cytochrome P-450, NADPH-Cytochrome P-450 Reductase, Epoxide Hydratase, and Alcohol Dehydrogenase

Evidence for Inhibitory Complexed Formed with Cytochrome P-450 and a Metabolite of 1,1-Disubstituted Hydrazines

Ovarian Aryl Hydrocarbon Hydroxylase Activity and Oocyte Destruction

Binding of Reactive Metabolites of Aromatic Hydrocarbons to Specific Microsomal Proteins

Secondary Oxygenation of the Carcinogen 2-AcetylaminoFluorene (= 2-AAF) In Vitro and In Vivo

Metabolism of 7,12-Dimethylbenz(a)anthracene in Rat Adrenals

The Influence of Organic Solvents on Cytochrome P-450-Mediated Metabolism of Biphenyl and Benzo(a)pyrene

Effects of Estrone, Estradiol, and Estriol Pretreatment on Hepatic, Lung, and Intestinal Aryl Hydrocarbon Hydroxylase Activities in Female Rats

Formation of Benzo(a)pyrene Metabolites in Isolated Intestinal Sacs

Index for Volumes I and II