Metals and Genetics

by International Symposium on Metals and Genetics, Bibudhendra Sarkar (Editor)

Overview

This book covers significant discoveries in the rapidly advancing field of metals and genetics. The aim of this volume is to bring together investigators from diverse fields of clinical medicine, genetics, biochemistry, and chemistry to reflect on the broad implications of direct and indirect interactions of metals and genetic components. The volume is divided into five sections. The first discusses genetic response to environmental exposure to metals. The section on metal carcinogenesis and metal caused DNA damage presents the latest advances in our knowledge of the molecular mechanisms of metal-induced mutagenis and carcinogenesis. A section is devoted to metals and neurodegenerative diseases. The identification of several disease genes related to metals is a major breakthrough in recent years. The section on genetics and biochemistry of metal-related diseases presents authoritative accounts of current information on both inherited and acquired metal-related diseases. They have discussed the genetics and pathophysiology of these diseases and reported the cloning, expression, purification, and characterization of gene products. Exciting results have been reported recently describing regulation of gene expression by metals. Chapters in this section on metals and gene regulation report recent advances dealing with the mechanism of metal-mediated regulation and control of gene expression.

Product Details

ISBN-13:	9780306461019
Publisher:	Springer-Verlag New York, LLC
Publication date:	05/28/1999
Edition description:	New Edition
Pages:	406
Product dimensions:	6.69(w) x 9.61(h) x 0.94(d)

About the Author

Sarkar, Bibudhendra (Univ of Toronto)

Table of Contents

Eulogy for Karen Wetterhahn: As an Introduction to the Session “Genetic Response to Environmental Exposure to Metals” for the Second International Symposium on Metals and Genetics.- Genetic Response to Environmental Exposure to Metals and Metal Transport.- 1. Metalloregulation of Soft Metal Resistance Pumps.- 2. Clastogenic Effects and Influence of Inorganic Arsenic on DNA-Repair in Mammalian Systems.- 3. Groundwater Arsenic Contamination and Sufferings of People in West Bengal, India and Bangladesh: Status Report Up to March, 1998.- 4. The Nature and Extent of Arsenic-Affected Drinking Water in Bangladesh.- 5. Chromium Biomonitoring: Achievements, Problems, and Future Challenges.- 6. Chelate Sensor Method for Mercury.- 7. Copper Transport and Ceruloplasmin during Lactation and Pregnancy.- Metal Carcinogenesis and Metal Caused DNA Damage.- 8. CAP43: A New Gene Induced by a Rise in Free Intracellular Ca2+ following Ni2+ Exposure.- 9. Zinc and Metallothionein in Mammalian Cell Cycle Regulation.- 10. Effect of Metal Compounds on the Function of Zinc Finger Proteins Involved in DNARepair.- 11. Chromium(III) as a Male Preconception Carcinogen in Mice.- 12. DNA Cleavage vs. Cross-Linking Using Nickel Peptides: Mechanistic Aspects.- 13. Copper-Dependent DNA Scission 197.- 14. Modulation of Glucocorticoid Signaling and Leukocyte Activation by Transition Metals.- Metals and Neurodegenerative Diseases.- 15. Reactions of Copper-Zinc Superoxide Dismutases with Hydrogen Peroxide: Possible Involvement in Familial Amyotrophic Lateral Sclerosis.- 16. Yeast Mihondrial Iron Metabolism and the Pathophysiology of Friedreich’ Ataxia.- 17. Getting Copper into Mihondria.- Genetics and Biochemistry of Metal-Related Diseases.- 18. The Copper-Transporting ATPase Defective in Wilson Disease.- 19. Towards the Characterization of the Wilson Disease Copper ATPase Metal Binding Domain.- 20. Molecular Genetics of Menkes Disease.- 21. Mutational Analysis of the Copper ATPase Affected in Menkes Disease.- 22. Clinicopathological and Molecular Genetic Features of Hereditary Ceruloplasmin Deficiency (Aceruloplasminemia).- 23. Copper Related Liver Disease in Young Children.- Metals and Gene Regulation.- 24. Regulation of Zinc Homeostasis in Yeast by the ZAP1 Transcriptional Activator.- 25. Embryonic Liver Degeneration and Increased Sensitivity Towards Heavy Metal and H2O2 in Mice Lacking the Metal-Responsive Transcription Factor MTF-1.- 26. The Transport and Intracellular Trafficking of Metal Ions in Yeast.- 27. Mechanisms of Copper Chaperone Proteins.- 28. Transcriptional Regulation of the Gene Encoding Mouse Metallothionein-3.- Contributors.

Editorial Reviews

Reviewer: John Balbus, MD, MPH (George Washington University)
Description: This book respresents a focus on both molecular and toxicological aspects of metal genetics. The coverage of genetic response to environmental exposure and monitoring in addition to metal carcinogenesis and metal-induced DNA damage is quite interesting.
Purpose: This text contains the proceedings of the Second International Symposium on Metals and Genetics. The main purpose is to provide the state-of-the-art on a variety of subjects related to metal-genome interactions.
Audience: According to the author, this book is intended for researchers in a wide array of disciplines including biochemistry, genetics, toxicology, and medicine. The generalist will obtain a useful overview of the field. Specialists of the various disciplines will likely find individual chapters that best meet their needs. The chapters in which genetics and molecular biology are covered may be a bit technical for those not involved in these fields.
Features: Chapters are divided into five categories: genetic responses to environmental metal exposures, metal-related carcinogenesis and DNA damage, metals and neurodegenerative diseases, genetics and biochemistry of metal-related diseases, and metals and gene regulation. Within each category, contributions may range from technical reports of laboratory research to epidemiologic and clinical discussions. This creates a somewhat kaleidoscopic view of this broad topic; as the author notes in his preface, only selected highlights of recent advances are included.
Assessment: Although the focus of this book is quite broad, there are important papers on a variety of topics. Overall quality ranges from very good to excellent, thanks to the participation of notable scientists in each field. There are few comparison texts, as most other texts focus more exclusively on a single topic or disciplinary approach.

Doody's Review Service

3 Stars from Doody

This book respresents a focus on both molecular and toxicological aspects of metal genetics. The coverage of genetic response to environmental exposure and monitoring in addition to metal carcinogenesis and metal-induced DNA damage is quite interesting. This text contains the proceedings of the Second International Symposium on Metals and Genetics. The main purpose is to provide the state-of-the-art on a variety of subjects related to metal-genome interactions. According to the author, this book is intended for researchers in a wide array of disciplines including biochemistry, genetics, toxicology, and medicine. The generalist will obtain a useful overview of the field. Specialists of the various disciplines will likely find individual chapters that best meet their needs. The chapters in which genetics and molecular biology are covered may be a bit technical for those not involved in these fields. Chapters are divided into five categories: genetic responses to environmental metal exposures, metal-related carcinogenesis and DNA damage, metals and neurodegenerative diseases, genetics and biochemistry of metal-related diseases, and metals and gene regulation. Within each category, contributions may range from technical reports of laboratory research to epidemiologic and clinical discussions. This creates a somewhat kaleidoscopic view of this broad topic; as the author notes in his preface, only selected highlights of recent advances are included. Although the focus of this book is quite broad, there are important papers on a variety of topics. Overall quality ranges from very good to excellent, thanks to the participation of notable scientists in each field. There are few comparisontexts, as most other texts focus more exclusively on a single topic or disciplinary approach.

John Balbus

Scientists from clinical medicine, genetics, biochemistry, chemistry, and other disciplines reflect on the broad implications of direct and indirect interactions of metals and genetic components. The 28 papers cover genetic responses to environmental exposure to metals and metal transport, metal carcinogenesis and metal-caused DNA damage, metals and neurodegenerative diseases, the genetics and biochemistry of metal-related diseases, and metals and gene regulation. Among the specific topics are the nature and extent of arsenic-affected drinking water in Bangladesh, copper-dependent DNA scission, yeast mitochondrial iron metabolism and the pathophysiology of Friedreich's Ataxa, the molecular genetics of Menkes Disease, and the regulation of zinc homeostasis in yeast by the ZAP 1 transcriptional activator. Annotation c. Book News, Inc., Portland, OR (booknews.com)

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