Metal Ions in Biological Systems: Volume 36: Interrelations Between Free Radicals and Metal Ions in Life Processes

by Astrid Sigel (Editor), Helmut Sigel (Editor)

Overview

Continues the tradition of excellence established in previous volumes in this acclaimed series. Volume 36 focuses on the vibrant research area concerning the interrelation between free radicals and metal ions and their resulting effects on life processes; it offers an authoritative and timely account of this fascinating area of research in 21 chapters.

Product Details

ISBN-13:	9781351432139
Publisher:	CRC Press
Publication date:	05/04/2018
Series:	Metal Ions in Biological Systems
Sold by:	Barnes & Noble
Format:	eBook
Pages:	848
File size:	7 MB

About the Author

Astrid Sigel

Table of Contents

The mechanism of Fenton-like reactions and their importance for biological systems - a biologist's view; reactions of aliphatic carbon-centred and aliphatic-peroxyl radicals with transition-metal complexes as a plausible source for biological damage induced by radical processes; free radicals as a result of dioxygen metabolism; free radicals as a source of uncommon oxidation states of transition metals; biological chemistry of copper-zinc superoxide dismutase and its link to amyotrophic lateral sclerosis; DNA damage mediated by metal ions with special reference to copper and iron; radical migration through the DNA helix - chemistry at a distance; involvement of metal ions in lipid peroxidation - biological implications; formation of methemoglobulin and free radicals in erythrocytes; role of free radicals and metal ions in the pathogenesis of Alzheimer's disease; metal binding and radical generation of proteins in human neurological diseases and aging; thiyl radicals in biochemically important thiols in the presence of metal ions; methymercury-induced generation of free radicals - biological implications; role of free radicals in metal induced carcinogenesis; pH-dependent organocobalt source for active radical species - a new type of anticancer agents; detection of chromatin-associated hydroxyl radicals generated by DNA-bound metal compounds and antitumor antibiotics; nitric oxide (NO) - formation and biological roles in mammalian systems; chemistry of peroxynitrite and its relevance to biological systems; novel nitric oxide-liberating heme proteins from the saliva of bloodsucking insects; nitrogen monoxide-related disease and nitrogen monoxide scavengers as potential drugs; therapeutics of nitric oxide modulation.

Editorial Reviews

This book will be of great interest to all interested in the role of metal ions in biology.

Applied Organometallic Chemistry Journal

...recommend[ed]. The editors deserve congratulation in selecting a first-rate group of authors and getting them to deliver.

Free Radical Research

Highlights the commonly accepted view about the role of oxygen-derived radicals in aging and their involvement in diseases such as cancer, atherosclerosis, Alzheimer's disease, amyloidosis, and osteoarthritis. Describes the damage to DNA by radicals and their migration through the DNA helix, lipid peroxidation, the formation of methemoglobin, the role of thiyl radicals, and other topics. Also explores the role of nitrogen monoxide, or nitric oxide, a ubiquitous biological messenger molecule, and its interplay with metal ions, and the potential clinical use of nitrogen monoxide modulators in certain diseases. No scientific consensus has been reached on many of the topics and contributors of the 21 studies do not always agree with each other. Annotation c. Book News, Inc., Portland, OR (booknews.com)

Booknews

"This book will be of great interest to all interested in the role of metal ions in biology."
—-Applied Organometallic Chemistry Journal
". . .recommend[ed]. The editors deserve congratulation in selecting a first-rate group of authors and getting them to deliver."
—-Free Radical Research

From the Publisher