Membrane Microdomain Signaling: Lipid Rafts in Biology and Medicine / Edition 1

by Mark P. Mattson

Overview

Cutting-edge articles review our current understanding of lipid microdomain signaling mechanisms and their physiological and pathological importance. The book describes the role of lipid rafts in learning, memory, and cancer, presents the emerging evidence that lipid rafts play critical roles in signaling pathways and the regulation of synaptic function in the nervous system, and shows how alterations in lipid raft metabolism are implicated in the pathogenesis of neurodegenerative disorders. Techniques are also described for the isolation of lipid rafts, the analysis of the lipid and protein components of lipid rafts, the imaging of lipid rafts in living cells, and the analysis of signal transduction in lipid rafts.

Product Details

ISBN-13:	9781617375156
Publisher:	Springer-Verlag New York, LLC
Publication date:	11/05/2010
Edition description:	Softcover reprint of hardcover 1st ed. 2005
Pages:	214
Product dimensions:	5.98(w) x 9.02(h) x 0.02(d)

Table of Contents

From Intramolecular Asymmetries to Raft Assemblies.- Regulatory Aspects of Membrane Microdomain (Raft) Dynamics in Live Cells.- Lipid Raft Membrane Skeletons.- Role of Cholesterol in Membrane Microdomain Signaling.- Raft Lipid Metabolism in Relation to Alkyl-Lysophospholipid-Induced Apoptosis.- The Role of Lipid Rafts in Signal Transduction and Synaptic Plasticity of Neural Cells.- Role of Rafts in Virus Fusion and Budding.- Alterations in Raft Lipid Metabolism in Aging and Neurodegenerative Disorders.- Caveolin and Cancer.- Dietary Modulation of Lipid Rafts.

Editorial Reviews

"...a good acquisition for general medical and neuroscience libraries." - Doody's Health Science Book Review Journal

From the Publisher

Reviewer: Celso Agner, MD, MS, MSc (Michigan Neurology Partners)
Description: The potential membrane effects on behavior have been proven in the past. This book addresses the membrane as the controller of cellular signaling.
Purpose: The purpose is to determine the nature of the lipid rafts in the determination of cell signaling.
Audience: Neuroscientists are the main targets for this book.
Features: The 10 chapters are written by 25 authors. The thrust of the book is to address the function of lipids in the transmission of signals from the extracellular environment to the internal cellular milieu. The incorporation of cholesterol particles in the membranes determines reproduction of genetic behaviors not previously imagined. There is also a direct relationship with specific membrane diseases that will potentially be managed by targeted therapy to the cellular membrane lipids.
Assessment: This is a good acquisition for general medical and neuroscience libraries.

Doody's Review Service