Mechanisms of Sepsis-Induced Organ Dysfunction and Recovery / Edition 1

by E. Abraham, Mervyn Singer

Overview

There have been tremendous advances in understanding the cellular mechanisms involved in sepsis and contributing to the development of multiple organ dysfunction and mortality in this setting. The chapters in this book provide up-to-date insights into important pathways that are initiated by sepsis.

Product Details

ISBN-13:	9783540301585
Publisher:	Springer Berlin Heidelberg
Publication date:	10/11/2007
Series:	Update in Intensive Care Medicine
Edition description:	2007
Pages:	453
Product dimensions:	6.10(w) x 9.20(h) x 0.70(d)

Table of Contents

Setting the Scene.- Setting the Scene.- The Inflammatory Response.- Genetics and Severe Sepsis.- Cell Signaling Pathways of the Innate Immune System During Acute Inflammation.- Early-Onset Pro-inflammatory Cytokines.- The Significance of HMGB1, a Late-Acting Pro-inflammatory Cytokine.- Nitric Oxide.- Involvement of Reactive Oxygen and Nitrogen Species in the Pathogenesis of Acute Lung Injury.- Heat Shock Proteins in Inflammation.- Fibrosis in the Acute Respiratory Distress Syndrome.- Resolution of Inflammation.- The Cellular Immune Respone.- Compartmentalized Activation of Immune Cells During Sepsis and Organ Dysfunction.- The Neutrophil in the Pathogenesis of Multiple Organ Dysfunction Syndrome.- The Role of the Macrophage.- The Role of the Endothelium.- Differential Effects of Pro-Inflammatory Mediators on Alveolar Epithelial Barrier Function.- Mechanisms and Pathways of Dysfunction.- Macrocirculatory Disturbances.- The Microcirculation Is a Vulnerable Organ in Sepsis.- The Cholinergic Anti-inflammatory Pathway: Connecting the Mind and Body.- Coagulation in Sepsis.- The Role of Insulin and Blood Glucose Control.- Dysfunction of the Bioenergetic Pathway.- Metabolic Pathways.- Cell Death and Acute Lung Injury.- Mechanisms of Immunodepression after Central Nervous System Injury.- Organ-specific Mechanisms of Dysfunction.- Pulmonary Dysfunction.- The Gut.- Endogenous Danger Signals in Liver Injury: Role of High Mobility Group Box Protein-1.- Sepsis-induced Acute Renal Failure and Recovery.- Sepsis-Induced Brain Dysfunction.- Myocardial Depression in Sepsis and Septic Shock.- Skeletal Muscle.

Editorial Reviews

Reviewer: David Dries, MSE, MD (Regions Hospital)
Description: This collection of essays, volume 44 in the Update in Intensive Care and Emergency Medicine series, describes specific patterns and mediators of organ failure in the setting of infection.
Purpose: Global mediators, cellular and tissue-specific changes in the setting of infection are collected from reports of the laboratories doing this work.
Audience: Senior trainees and practitioners in multidisciplinary critical care medicine are an appropriate audience for this book edited and written by an international group of critical care and sepsis leaders.
Features: After introductory comments that provide a unifying force for the presentations, mediators of inflammation are discussed followed by components of the pattern of cellular injury seen in sepsis. Later chapters include metabolic changes and a concluding group of essays focus on organ specific dysfunction. Chapters are well written and include line drawings and tables to summarize data. An ample reference list follows each presentation with references dating to within two years of publication, which represent original work.
Assessment: This is a good compilation of recent work done at the level of cytokines, cells, and tissues to help understand and treat this important problem. Consistent with clinical practice, cellular and organ dysfunction are emphasized while we still know relatively little about the tipping point between cell and tissue death and recovery. This is a worthy overview for the academic clinician facing sepsis at the bedside.

Doody's Review Service