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Overview
Newly added chapters feature case-study-driven discussions of morphogenesis in natural embryos and organoids, and illustrate how pathological morphogenesis can generate variants of body form. This edition has also been updated with analysis of large-scale and scale-invariant mechanisms, for example, morphogenesis by differential growth in mechanically connected tissues.
Product Details
ISBN-13: | 9780323999656 |
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Publisher: | Elsevier Science |
Publication date: | 06/14/2023 |
Edition description: | 3rd ed. |
Pages: | 532 |
Product dimensions: | 7.50(w) x 9.25(h) x (d) |
About the Author
Davies has published around 140 research papers in the field of mammalian development, has published one major specialist monograph (Mechanisms of Morphogenesis, Elsevier, 2005 2nd Ed 2014), one public engagement book (Life Unfoloding, OUP, 2013 (Hardback), 2015 (paperback), now in translation also) and has edited three multi-author books in the fields of development, stem cells and tissue engineering. His contributions to research and teaching in this area have been recognized by having been elected a Fellow of the Royal Society of Biology, a Fellow of the Royal Society of Medicine and a Principal Fellow of the Higher Education Academy. Davies served as Deputy Chair of the National Centre for 3Rs, a government agency that promotes research that refines, reduces or replaces animal experiments. He has also served as Editor-in-Chief of the research journal Organogenesis for 8 years, and is currently an Editor of Journal of Anatomy and PLOS One.
Table of Contents
Section I: Introduction 1. General introduction – the aims and structure of this book. 2. Key principles of morphogenesis 3. The power and limitations of self-assemblySection II: Cell shape and the cell morphogenesis 4. Morphogenesis of individual cells 5. Animal cell shape: the importance of the cytoskeleton 6. Cellular morphogenesis in plants
Section III: Cell Migration 7. Cell migration in development: a brief overview 8. The nanomachinery of locomotion 9. Guidance by chemotaxis 10. Guidance by galvanotaxis 11. Guidance by contact 12. Waypoint navigation in the embryo 13. Cooperative migration of mesenchymal cells 14. Condensation of cells
Section IV: Epithelial Morphogenesis 15. The epithelial state: a brief overview 16. Neighbour exchange and convergent extension 17. Closure of holes 18. Invagination and evagination 19. Epithelial fusion 20. Epithelial branching 21. Boundaries to epithelial movement
Section V: Morphogenesis by cell proliferation and death 22. Growth, proliferation and death: a brief overview 23. Morphogenesis by orientated cell division 24. Morphogenesis by elective cell death
Section VI: Morphogenesis in context 25. From mechanisms to morphology: a brief overview 26. Morphogenesis in embryos: some illustrative examples 27. Morphogenesis in organoids, embryoids and engineered tissues 28. Pathological morphogenesis
Section VII: Modelling morphogenesis 29. Modelling morphogenesis: a brief overview 30. Mechanical and mathematical models of morphogenesis 31. Modelling using living cells – tissue engineering and synthetic morphology
Section VIII: Conclusion and perspectives 32. Conclusion and perspectives
What People are Saying About This
An outstanding reference with up-to-date knowledge and approaches in morphogenesis