Management of Complex Treatment-resistant Psychotic Disorders

by Michael Cummings (Editor), Stephen Stahl (Editor)

Overview

This full-color, practical handbook provides a concise, evidence-based psychopharmacological approach to the management of complex treatment-resistant psychotic disorders. Part I focuses uniquely on topics and strategies relevant to treating this challenging patient population. These approaches go beyond standard guidelines while adhering to research and clinically derived data. Part II provides a concise array of information regarding those classes of medications most commonly used when treating complex treatment-resistant psychotic disorders. Each medication guide contains sections including mechanisms of action, typical treatment response, monitoring, dosing and kinetics, medications to avoid in combination/warnings, and take-home pearls. Part III offers tips in brief appendix chapters for managing common issues ranging from loading lithium and valproic acid to the treatment of acute psychomotor agitation. An essential resource for psychiatrists, forensic clinicians, psychiatric trainees, and all mental health professionals involved with, or interested in, the treatment of challenging psychotic disorders.

Product Details

ISBN-13:	9781108965682
Publisher:	Cambridge University Press
Publication date:	07/22/2021
Pages:	538
Sales rank:	497,844
Product dimensions:	5.39(w) x 8.94(h) x 0.91(d)

About the Author

Michael A. Cummings is Clinical Professor of Psychiatry at the University of California, Riverside, Associate Clinical Professor of Psychiatry at the University of California, Irvine and Senior Psychiatrist Specialist at the California Department of State Hospitals.

Stephen M. Stahl is Adjunct Professor of Psychiatry at the University of California, San Diego, Clinical Professor of Psychiatry and Neuroscience at the University of California, Riverside, and Honorary Visiting Senior Fellow in Psychiatry at the University of Cambridge.

Table of Contents

Part I. Treatment Strategies: 1.01. Approaches to positive Psychotic symptoms; 1.02. Use of plasma levels in Antipsychotic and Mood Stabilizer treatment; 1.03. Advantages of long-acting injectable Antipsychotics; 1.04. Approach to Schizophrenia Spectrum treatment-resistant patients; 1.05. Approach to depressed or suicidal Schizophrenia Spectrum patients; 1.06. Approach to persistent aggression and violence in Schizophrenia Spectrum Disorders; 1.07. Approach to treatment of Bipolar Diathesis in Schizophrenia Spectrum patients; 1.08. Approach to Anxiety in Schizophrenia Spectrum patients; 1.09. Approach to Insomnia and Sleep Disturbance in Schizophrenia Spectrum disorders; 1.10. Approach to Psychosis in children and adolescents; 1.11. Electro-convulsive therapy and other Non-pharmacological treatments; 1.12. Approach to substance use disorders in Schizophrenia Spectrum Disorders; 1.13. Approaches to Behavioral Disturbances and Dementia and TBI patients; Part II. Medication Reference Tables: First-generation (Typical) Antipsychotics: 2.01. Chlorpromazine; 2.02. Fluphenazine; 2.03. Haloperidol; 2.04. Loxapine; 2.05. Perphenazine; 2.06. Thiothixene; 2.07. Trifluoperazine; Second-generation (Atypical) Antipsychotics: 2.08. Asenapine; 2.09. Clozapine; 2.10. Iloperidone; 2.11. Lumateperone; 2.12. Lurasidone; 2.13. Olanzapine; 2.14. Paliperidone; 2.15. Quetiapine; 2.16. Risperidone; 2.17. Ziprasidone; Dopamine Partial Agonist Antipsychotics (Arias): 2.18. Aripiprazole; 2.19. Brexpiprazole; 2.20. Cariprazine; Medications for Motor/Neurologic Adverse Effects: 2.21. Amantadine; 2.22. Benztropine; 2.23. Diphenhydramine; 2.24. Trihexyphenidyl; Mood Stabilizers: 2.25. Carbamazepine; 2.26. Lamotrigine ; 2.27. Lithium; 2.28. Valproic Acid; Selective Serotonin Reuptake Inhibitor (SSRI) Antidepressants: 2.29. Citalopram; 2.30. Escitalopram; 2.31. Fluoxetine; 2.32. Fluvoxamine; 2.33. Paroxetine; 2.34. Sertraline: SSRI/5HT-1 Partial Agonist Antidepressants: 2.35. Vilazodone; 2.36. Vortioxetine; Serotonin/Norepinephrine Reuptake Inhibitor (SNRI) Antidepressants; 2.37. Desvenlafaxine; 2.38. Duloxetine; 2.39. Levomilnacipran; 2.40. Venlafaxine; Mixed Mechanism Antidepressants: 2.41. Bupropion; 2.42. Mirtazapine; 2.43. Trazodone; Tricyclic Antidepressants: 2.44. Amitriptyline; 2.45. Clomipramine; 2.46. Desipramine; 2.47. Doxepin; 2.48. Imipramine; 2.49. Nortriptyline; Monoamine Oxidase Inhibitor (MAOI) Antidepressants: 2.50. Isocarboxazid; 2.51. Moclobemide; 2.52. Phenelzine; 2.53. Transdermal Segeliline; 2.54. Tranylcypromine; Anxiolytics: 2.55. Alprazolam; 2.56. Buspirone; 2.57. Clonazepam; 2.58. Diazepam; 2.59. Hydroxyzine; 2.60. Lorazepam; Sedatives: 2.61. Diphenhydramine; 2.62. Eszopiclone; 2.63. Hydroxyzine; 2.64. Lorazepam; 2.65. Oxazepam; 2.66. Temazepam; 2.67. Zaleplon; 2.68. Zolpidem; Circadian Regulators: 2.69. Melatonin; 2.70. Ramelteon; 2.71. Tasimelteon; Stimulants: 2.72. Atomoxetine; 2.73. Dextroamphetamine; 2.74. Lisdexamphetamine; 2.75. Methylphenidate; 2.76. Mixed Amphetamine Salts: Histaminic Stimulants: 2.77. Armodafinil; 2.78. Modafinil; Cognitive Agents: 2.79. Dextromethorphan/quinidine; 2.80. Donepizil; 2.81. Galantamine; 2.82. Memantine; 2.83. Rivastigmine; Alpha2-adrenergic Agonists: 2.84. Clonidine; 2.85. Guanfacine; Appendices: 3.01. Optimal Antipsychotic Plasma Concentration Ranges; 3.02. Optimal Mood Stabilizer Plasma Concentration Ranges; 3.03. Formulas for QT Interval Correction; 3.04. Common Cytochrome P-450 Inducers and Inhibitors; 3.05. Management of Constipation; 3.06. Child-Pugh Hepatic Function Scoring; 3.07. Loading of Lithium and Valproic Acid; 3.08. Treatment of Prolactin Elevation; 3.09. A Select List of Foods High in Tyramine; 3.10. Medications that Present Risk for Serotonin Syndrome when Combined with MAOIs; 3.11. Selected Treatment of Psychomotor Agitation.

Editorial Reviews

Reviewer: Michael Easton, MD (Rush University Medical Center)
Description: This book presents a concise, evidence-based psychopharmacological approach to the management of difficult-to-treat psychotic disorders.
Purpose: This book is designed to present up-to-date, evidence-based information regarding the presentation and clinical pharmacological treatment of psychotic disorders, focusing on more difficult-to-treat cases that are treatment resistant or present with comorbidities. The goal is to help prescribers working in the most challenging psychiatric environments to better manage this challenging patient population.
Audience: This book is a condensed but thorough review of current evidence for pharmacological management of complicated psychotic disorders. It is meant to provide the clinically relevant information for clinicians working with this challenging population. It is also an excellent text for medical students, residents, nurses, social workers, and other clinicians treating individuals with psychotic disorders.
Features: This book is organized into two parts. The first part starts by looking at approaches to the management of positive psychotic symptoms and various aspects of prescribing and monitoring pharmacotherapy. It then goes on to explore issues around treatment resistance and evidence for various treatment strategies as well as the management of specific problems such as aggression, depression, suicidality, mood instability, substance abuse, and special populations such as children, adolescents, and older adults. The second section goes over specific agents in various classes used in this patient population. The information is provided in a variety of graphic tables looking at basic information, receptor effects, lab monitoring, target symptoms, dosing considerations, drug-drug interactions and cautions, and "take home pearls."
Assessment: This book is written in the typical Dr. Stahl fashion: an up-to-date, clinically relevant, evidence-based, information-dense book presented in a graphic style that is easy to read and navigate. The book is clearly useful for medical students, residents, and young psychiatrists. Even seasoned psychiatrists can utilize it to easily keep up to date on the many factoids regarding various medications in the ever-expanding pharmacological universe.

Doody's Review Service

‘The book is clearly useful for medical students, residents, and young psychiatrists.’ Michael Easton, Doody's Notes

From the Publisher