Local Immunosuppression of Organ Transplants

by Scott A. Gruber

Overview

For the first time a complete review of the research work done over the past 30 years by leading investigators around the world in targeting immunosuppressants to both solid-organ and cellular transplants is available in a single volume. One section consists of studies conducted in rat allograft models using osmotic minipumps for delivery of a variety of immunosuppressants. The book will be of great benefit to researchers in the fields of transplant immunology, pharmacology and drug delivery and targeting, particularly those involved in drug development.

Product Details

ISBN-13:	9783662221075
Publisher:	Springer Berlin Heidelberg
Publication date:	06/15/2013
Series:	Medical Intelligence Unit
Edition description:	Softcover reprint of the original 1st ed. 1996
Pages:	217
Product dimensions:	7.01(w) x 10.00(h) x 0.02(d)

About the Author

Gruber, Scott A., MD, PhD (Albany Medical Coll)

Most of the contributors are from academic medical centers in the U.S. and Japan. Institutions prominently represented include Stanford, UCSF, Univ of Michigan, Univ of Pittsburgh, Univ of Pennsylvania, Univ of Minnesota, Washington Univ, Albany Medical Coll, Univ of Texas, and Nara Medical Univ.

Table of Contents

Section A: Background.- 1. Local Regulation of Allograft Rejection.- 2. Pharmacokinetic Advantage of Regional Drug Delivery.- 3. Early Studies of Local Immunosuppression (1964–1984).- Section B: Pump-Based Local Infusion in Rat Allograft Models.- 4. Selective Immunosuppression by Local Treatment of the Allograft: Studies on Intrarenal Prednisolone and Intracardiac Budesonide Delivery in the Rat.- 5. Local Immunosuppression of Rat Cardiac, Liver, and Small Bowel Allografts.- 6. Inhibition of Cardiac Allograft Rejection by Continuous Local Infusion of 16,16 Di-Methyl PGE2.- 7. Intrarenal Administration of Anti T Cell-Monoclonal Antibody.- 8. Intraportal Delivery of Immunosuppressants to Intrahepatic Islet Allografts.- Section C: Pump-Based Local Infusion in Canine Allograft Models.- 9. Local Heparin, 6-Mercaptopurine, Prednisolone, and Mizoribine Delivery in a Canine Renal Allograft Model.- 10. Intraportal Cyclosporine A in Canine Liver Transplantation.- Section D: Other Drug Targeting Systems for Achieving Local Immunosuppression.- 11. Liposomal Cyclosporine A.- 12. Liposomal FK506 in a Canine Hepatic Allograft Model.- 13. Cyclosporine Aerosol in Lung Transplantation.- 14. Site-Specific Immunosuppression with Topical Agents.- 15. Local Immunosuppression in Corneal Transplantation.- 16. Controlled-Release Drug Matrices for Local Immunosuppression of Organ Transplants.- 17. Gene Transfer to the Transplanted Organ.- 18. Immunomodulation of Islet Allografts with Genetically Modified Muscle Cells.- 19. Sertoli Cells in Islet Transplantation: Testicular Immune Privilege.- Section E: Conclusion.

Editorial Reviews

3 Stars from Doody

This is the first edition of a textbook reviewing strategies in local immunosuppression. After reviewing the scientific premises, local infusion techniques are described. The remainder of the book is devoted to novel systems of targeting immunosuppression including liposomal therapy, gene transfer, and the use of immunologically privileged sites. As outlined in the preface, the editor and authors have attempted to review 30 years of research on targeting immunosuppression to both solid organ and cellular transplants. Apart from occasional reviews, this area of transplant immunology has received relatively little attention, and this overview is a welcome addition to the literature. Because of the relatively narrow scope of the subject matter, this textbook is most appropriate for investigators and students interested in this approach to immunosuppression. The book may also be of interest to transplant physicians and surgeons. The contributing authors comprise an international group of scientists who have studied various approaches to local immunosuppression. The number of illustrations is appropriate. However, the figures vary in quality and format. In addition, color photomicrographs would be more useful. Many of the references are up-to-date. However, there are several chapters with numerous references that are 10 to 15 years old with relatively few recent references. The index would be more useful if it omitted references to authors and extensive abbreviations. This interesting overview of novel approaches to immunosuppression is a worthwhile addition to the literature. The introduction outlines the immunologic and pharmacologic rationale as well as the historicalbackground. Numerous contributors have outlined a variety of approaches to local immunosuppression. The unique aspect of this book is its subject matter, which provides potential avenues for future investigation. I would recommend that this book be purchased by medical bookstores, libraries, and investigators in the field of local immunosuppression.

Gary G. Singer

A complete review of the literature of the past 30 years in the use of local immunosuppressants in both solid-organ and cellular transplants. Section I provides background on the local regulation of allograft rejection and the pharmacokinetic advantage of regional drug delivery, as well as studies performed before 1984. The rest of the material is devoted to research performed over the past decade, highlighting studies conducted in rat and canine allograft models using pump and catheter systems, and studies using various drug-targeting systems including aerosol inhalation and gene transfer. Of interest to researchers in bioscience and medicine. Annotation c. Book News, Inc., Portland, OR (booknews.com)

Booknews