Kinetic Models of Trace Element and Mineral Metabolism During Development

by K. N. Siva Subramanian, Meryl E. Wastney-Pentchev

Overview

Kinetic models are becoming standard tools in the research of biological systems. They are used to represent hypotheses, analyze data, and design experiments to maximize the information obtained from a study. Kinetic Models of Trace Element and Mineral Metabolism During Development describes models for calcium, chromium, copper, iron, iodide, lead, mercury, selenium, zinc, and others in health and disease.

Product Details

ISBN-13:	9781000722130
Publisher:	CRC Press
Publication date:	01/29/2020
Sold by:	Barnes & Noble
Format:	eBook
Pages:	420
File size:	14 MB
Note:	This product may take a few minutes to download.

About the Author

K. N. Siva Subramanian, M.D. is a Professor, Department of Pediatrics and Obstetrics and Gynecology, Georgetown University Medical Center, Washington, D.C. He obtained his M.B.B.S. (M.D.) degree from Madras University in 1969 and is board certified in Pediatrics and Neonatal-Perinatal Medicine. He has been Chief of Neonatal-Perinatal Medicine and Director of Nurseries at Georgetown University Hospital since 1981. He is currently Chair of the Georgetown University Hospital Committee on Bioethics. He is a member of the American Medical Association, the American Society of Parenteral and Enteral Nutrition, the International Society for Trace Element Research in Humans, the Society for Bioethics Consultation, and a Fellow of the American Academy of Pediatrics, the Kennedy Institute of Ethics, and the American College of Nutrition. He is listed in the Who's Who in Science and Engineering and Who's Who in the World. He has published over 40 articles and books, presented numerous lectures nationally and internationally, and has trained over 40 fellows in neonatal/perinatal medicine. His current interests are in infant mortality reduction, bioethics-decision making in critical care nursery, and trace element metabolism in newborn infants. Meryl E. Wastney, Ph.D. is an Associate Professor, Department of Pediatrics, Georgetown University Medical Center, Washington, D.C. She graduated with a B.Ag.Sc. (1st Class Honors) in 1976 and a Ph.D. in 1980 from Lincoln College, University of Canterbury, New Zealand. She was a Fogarty Fellow in the Laboratory of Mathematical Biology, NCI, NIH, Bethesda, MD for 3 years and joined the Department of Pediatrics at Georgetown University in 1983. She is a member of the American Institute of Nutrition, the American Institute of Clinical Nutrition, the International Society for Trace Element Research in Humans, and a Fellow of the American College of Nutrition. She was the recipient of the W.O. Rennie Memorial Prize, the Lincoln Senior Scholarship, the Shirtcliffe Fellowship, the Sir James Gunson Scholarship, the University Grants Committee Postgraduate Scholarship, and an NIH Fogarty Visiting Fellowship. She is an author of 26 articles and chapters and has presented over 20 invited lectures and workshops on modeling biological systems. Her current interests are trace element and mineral metabolism in infants and adolescents.

Table of Contents

Contributors, Preface, I. PREGNANCY AND LACTATION, 1. Use of Mineral Stable Isotopes in the Study of Nutrient, Homeostasis During Human Pregnancy and Lactation, 2. Kinetic Overview: Modeling Calcium Metabolism in Pregnant and Lactating Cows, 3. Calcium Metabolism in Pregnancy and Lactation: An Individual Study, 4. Copper Metabolism in Dairy Cows: Development of a Model Based on a Stable Isotope Tracer, II. NEONATES AND CHILDREN, 5. Zinc Kinetics in Humans, 6. Stable Isotope Studies of Zinc Kinetic Metabolism in Infants, 7. Determination of Mineral Absorption by Very Low Birthweight Preterm Infants with the Stable Isotope Extrinsic Tag Approach, III. ADOLESCENTS AND ADULTS, 8. Determination of Requirements, 9. Contributions of Mathematical Models to Understanding of Human Iodide Metabolism, 10. Zinc that Exchanges with Zinc in Plasma Within Two Days: Variation with Dietary Zinc, 11. Calcium Metabolism in Adolescents, 12. Stable Isotopes of Copper, Molybdenum, and Zinc Used Simultaneously for Kinetic Studies of their Metabolism, 13. Reference Values for Trace Elements in Human Clinical Specimens: With Special Reference to Biomonitoring and Specimen Suitability, IV. DISORDERS, 14. Studies of Calcium Metabolism in Children with Chronic, Illnesses, 15. Historical Overview of Copper Kinetics, 16. Compartmental Analysis of Intestinal Iron Absorption and Mucosal Iron Kinetics, 17. Chromium (III) Metabolism in Diabetic Patients, 18. A Calcium-based Model of Human Lead Kinetics, V. ENVIRONMENTAL HEALTH, 19. Some Constitutive Modifiers of the Kinetic and Dynamic, Behavior of Non-essential Metals, 20. An Overview of Selenium Kinetics in Humans, 21. The Kinetics of Intravenously-Administered Inorganic, Mercury in Humans, VI. CALCIUM METABOLIC DYNAMICS, 22. Overview of Calcium Metabolic Dynamics, 23. Interpretation of Stable Isotope Studies of Calcium Absorption, and Kinetics, 24. Calcium Homeostasis - an Old Problem Revisited, 25. Generalized Stochastic Compartmental Models of Calcium, Metabolism, 26. Frequency Response of the Calcium Control System, 27. Regulation in Oscillatory Models., 28. Optimal Sampling for the Determination of Calcium Metabolism, 29. Determination of Bone Resorption, VII. MODELING THEORY AND SOFTWARE, 30. Kinetic Models to Describe Populations: A Strategy for, Summarizing the Results of Multiple Studies, 31. SAAMEASE: The Language of SAAM and CONSAM, INDEX, APPENDIX Diskette containing CONSAM program and models