Joint Replacement and Bone Resorption: Pathology, Biomaterials and Clinical Practice

by Arun Shanbhag (Editor), Harry E. Rubash (Editor), Joshua J. Jacobs (Editor)

Overview

This first guide devoted to this burgeoning topic, this authoritative reference presents the current understanding of the phenomenon of aseptic loosening of total joint replacements from the molecular and cellular mechanisms of periprosthetic bone loss to the clinical presentation and management strategies-reviewing the properties of ceramic, metal, and polymer materials used in the replacement of joints, as well as current research on bone remodeling, wear resistance, the long-term care of implants, and emerging developments in gene therapy and tissue engineering.

Product Details

ISBN-13:	9780824729547
Publisher:	Taylor & Francis
Publication date:	11/09/2005
Pages:	822
Product dimensions:	6.00(w) x 9.00(h) x (d)

About the Author

Arun Shanbhag, Harry E. Rubash, Joshua J. Jacobs

Table of Contents

Clinical Practice. Historical Perspective. Fixation of Implants. THR: Incidence of Bone Loss and Clinical Presentation. TKR: Incidence of Bone Loss and Clinical Presentation. Histopathology of Periprosthetic Tissues. Biomaterials Wear Debris. Basic Science. Properties of Materials Used in Joint Replacements. Wear in Joint Replacements. Human Motion and its Relevance to Wear. Corrosion. Inflammation and the Role of Macrophages. Cytokines and Mediators in Physiological and Pathologic Bone Resorption. Mechanisms of Peri-Implant Bone Loss. Wear Debris Induced Osteolysis. Role of Immune-Response in Implant Loosening. Stress-Induced Bone Remodeling. Pressure and Motion Induced Factors in Implant Loosening. Role of Endotoxin in Implant Loosening. Signal Transduction and Gene Regulation in Cell-Material Interactions. In-Vitro and In-Vivo Models to Study Osteolysis. Solutions and Treatments. Surgical Techniques: Modern Cementing Techniques. Treating Hip and Pelvic Osteolysis. Managing Knee Osteolysis. Advances in Metals. Advances in Polyethylene. Improving UHMWPE Using Electron Beam Irradiation. Alternate Bearing Materials: Metal-on-Metal. Alternate Bearing Materials: Ceramic-on-Ceramic. Future Perspectives. Tissue Engineering Alternatives to Joint Replacement. Enhancing Bone Ingrowth. Gene Therapy for Osteolysis. Pharmaceutical Treatment of Lysis. Genomics: The Promise for Orthopaedics

Editorial Reviews

Reviewer: Riad Barmada, MD (University of Illinois at Chicago College of Medicine)
Description: This book presents valuable information regarding bone resorption associated with total joint replacement, its history, clinical and radiological presentation, pathophysiology, and recommendation for management and prevention.
Purpose: The purpose is to provide a reference that includes recent advances and research findings.
Audience: Orthopedic surgeons, residents and researchers interested in joint replacement are the intended audience.
Features: The first of the book's five sections includes discussion of implant fixation in total thigh and total knee replacement and the clinical aspects of bone resorption. Section two is devoted to biomaterials used in joint replacement, mainly the wear particles produced by various materials and the role they play in bone resorption. Section three discusses various factors leading to peri-prosthetic bone resorption. Section four covers treatments and prevention of bone loss and section five relates the future role of tissue engineering in joint replacement.
Assessment: This book provides the most recent information regarding a common cause of failure of a total joint replacement; peri-prosthetic bone resorption. It is an excellent reference for this topic, well written and providing good understanding of the mechanism, pathophysiology, treatment, and prevention of bone loss. Many books have been published on joint replacement, but none has comprehensively addressed the issue of bone resorption associated with joint replacement failure and the research findings and related basic science involved. This is an outstanding publication and an excellent addition to the orthopedic literature.

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