International Review of Cell and Molecular Biology

by Kwang W. Jeon (Editor)

Overview

International Review of Cell and Molecular Biology presents current advances and comprehensive reviews in cell biology--both plant and animal. Articles address structure and control of gene expression, nucleocytoplasmic interactions, control of cell development and differentiation, and cell transformation and growth. Impact factor for 2008: 4.935.

• Authored by some of the foremost scientists in the field
• Provides up-to-date information and directions for future research
• Valuable reference material for advanced undergraduates, graduate students and professional scientists

Product Details

ISBN-13:	9780123812599
Publisher:	Elsevier Science
Publication date:	04/29/2010
Series:	ISSN , #281
Sold by:	Barnes & Noble
Format:	eBook
Pages:	280
File size:	6 MB

About the Author

Kwang Jeon received his Ph.D. in cell physiology at King’s College, University of London, UK, in 1964 and taught at SUNY Buffalo and University of Tennessee. His research was concerned with the biogenesis and function of cell components in two major areas: Integration of intracellular symbionts into host cells leading to the acquisition of new cell components and cell variation; Membrane-protein recycling during endo- and exocytosis.

Table of Contents

Contributors ix

1 Macromolecutar Trafficking and Immune Evasion in African Trypanosomes Mark C. Field Jennifer H. Lumb Vincent O. Adung'a Nicola G. Jones Markus Engstler 1

1 General Overview of the Trypanosome Life Cycle 3

2 Immune Evasion Mechanisms 5

3 Endocytrc Pathways 16

4 Developmental Remodeling and Signaling 27

5 Sorting Signals 28

6 Secretory Protein Folding and Exocytosis 32

7 Golgi Apparatus; Functions and Replication 39

8 Ubiquitylation and Endocytosis of Trans-Membrane Domain Proteins 42

9 Evolution of the Trypanosome Endomembrane System 46

10 Conclusions and Future Perspectives 50

Acknowledgments 51

References 52

2 Biological and Biophysical Properties of Vascular Connexin Channels Scott Johnstone Brant Isakson Darren Locke 69

1 Introduction 71

2 The Vasculature 72

3 Connexin Channels 75

4 Gap Junctional Communication Pathways in the Vasculature 82

5 Permeability of Vascular Connexin Channels 87

6 Involvement of Connexins in Vascular Diseases 101

7 Concluding Remarks 104

Acknowledgments 105

References 105

3 Genotype-Phenotype Mapping: Developmental Biology Confronts the Toolkit Paradox Joel Atallah Ellen Larsen 119

1 Introduction 120

2 Understanding the Genotype-Phenotype Relationship 121

3 From Sequence to Form 125

4 Beyond Sequence 135

5 Case Study for Parsing Gene, Cell and Self-Organizing Roles in Morphogenesis 138

6 Conclusion 142

Acknowledgments 142

References 142

4 Role of Spindle Asymmetry in Cellular Dynamics Yves Barral Dimitris Liakopoulos 149

1 Introduction 150

2 Spindle Asymmetry and Control of Cell Cycle 152

3 Spindle Asymmetry During Asymmetric Cell Divisions 174

4 Concluding Remarks201

References 203

5 Cell Adhesion in Amphibian Gastrulation Rudolf Winklbauer 215

1 Introduction 216

2 Characteristics of Amphibian Gastrulation 217

3 Gastrula Tissue as a Liquid: Cell Adhesion, Cell Sorting, Boundary Formation, and Tissue Positioning 223

4 Collective Cell Migration, Cell Rearrangement, and Intercellular Migration 249

5 Conclusion 260

Acknowledgments 261

References 261

6 Molecular and Cell Biology of Testicular Germ Cell Tumors Paolo Chieffi Renato Franco Giuseppe Portella 277

1 Introduction 278

2 Epidemiology and Risk Factors 279

3 Histopathology 280

4 Prognostic and Diagnostic Markers 294

5 Therapy 297

6 Conclusions and Perspectives 301

Acknowledgments 301

References 302

7 Polarity Proteins and Cell-Cell Interactions in the Testis Elissa W.P. Wong C. Yan Cheng 309

1 Introduction 310

2 Rho GTPases and Cell-Cell Interactions in the Testis: Cdc42 315

3 Polarity Proteins and Cell-Cell Interactions in the Testis 327

4 The Apical ES-BTB-Basement Membrane Functional Axis in the Seminiferous Epithelium that Coordinates the Cellular Events of Spermiation and BTB Restructuring During the Seminiferous Epithelial Cycle of permatogenesis: The Role of Polarity Proteins in Mediating the Apical ES-BTB-Basement Membrane Axis 335

5 Roles of Polarity Proteins in Coordinating the Opposing Effects of Cytokines and Testosterone in Primary Preleptotene Spermatocyte Transit at the BTB 339

6 Concluding Remarks and Future Perspectives 341

Acknowledgment 342

References 342

Index 355

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From the Publisher

Provides up-to-date information and directions for future research in the fields of cell and molecular biology