Injectable Biomaterials: Science and Applications

by Brent Vernon (Editor)

Overview

Novel injectable materials for non-invasive surgical procedures are becoming increasingly popular. An advantage of these materials include easy deliverability into the body, however the suitability of their mechanical properties must also be carefully considered. Injectable biomaterials covers the materials, properties and biomedical applications of injectable materials, as well as novel developments in the technology.Part one focuses on materials and properties, with chapters covering the design of injectable biomaterials as well as their rheological properties and the mechanical properties of injectable polymers and composites. Part two covers the clinical applications of injectable biomaterials, including chapters on drug delivery, tissue engineering and orthopaedic applications as well as injectable materials for gene delivery systems. In part three, existing and developing technologies are discussed. Chapters in this part cover such topics as environmentally responsive biomaterials, injectable nanotechnology, injectable biodegradable materials and biocompatibility. There are also chapters focusing on troubleshooting and potential future applications of injectable biomaterials.With its distinguished editor and international team of contributors, Injectable biomaterials is a standard reference for materials scientists and researchers working in the biomaterials industry, as well as those with an academic interest in the subject. It will also be beneficial to clinicians. - Comprehensively examines the materials, properties and biomedical applications of injectable materials, as well as novel developments in the technology - Reviews the design of injectable biomaterials as well as their rheological properties and the mechanical properties of injectable polymers and composites - Explores clinical applications of injectable biomaterials, including drug delivery, tissue engineering, orthopaedic applications and injectable materials for gene delivery systems

Product Details

ISBN-13:	9780857091376
Publisher:	Woodhead Publishing, Limited
Publication date:	01/24/2011
Series:	Woodhead Publishing Series in Biomaterials
Sold by:	Barnes & Noble
Format:	eBook
Pages:	440
File size:	6 MB

About the Author

Brent Vernon is Associate Professor of Bioengineering at Arizona State University, USA.

Table of Contents

Contributor contact details Part I: Materials and properties Chapter 1: Designing clinically useful substitutes for the extracellular matrix Abstract: 1.1 Introduction: the translational challenge 1.2 Design criteria for extracellular matrix (ECM) mimetics 1.3 Single-module semi-synthetic extracellular matrices (sECMs) based on hyaluronic acid (HA) 1.4 Adding function to hyaluronic acid (HA) matrices 1.5 Using injectable synthetic extracellular matrices (sECMs) in vivo 1.6 Conclusions and future trends Chapter 2: Designing ceramics for injectable bone graft substitutes Abstract: 2.1 Introduction 2.2 Rheological properties of bone substitute pastes 2.3 Handling and delivery 2.4 Mechanical and biological properties of bone substitute pastes 2.5 Industrial design 2.6 Future trends Chapter 3: Rheological properties of injectable biomaterials Abstract: 3.1 Introduction 3.2 Different types of in situ gelling materials: chemical gels, solvent exchange, and physical gels 3.3 Shrinkage, swelling, and evaporation 3.4 Kinetics and injectability 3.5 The role of statistics and uncertainty in rheological characterization 3.6 Future trends 3.7 Sources of further information and advice Chapter 4: Improving mechanical properties of injectable polymers and composites Abstract: 4.1 Introduction 4.2 Mechanical properties and testing 4.3 Injectable hydrogels 4.4 Non–hydrogel injectable polymers 4.5 Conclusion and future trends Part II: Clinical applications Chapter 5: Drug delivery applications of injectable biomaterials Abstract: 5.1 Introduction 5.2 Solvent exchange precipitating materials 5.3 Aqueous solubility change materials 5.4 In situ crosslinking or polymerizing materials 5.5 Microparticles and nanoparticles 5.6 Micelles and liposomes 5.7 Polymer-drug conjugates 5.8 Conclusion and future trends Chapter 6: Tissue engineering applications of injectable biomaterials Abstract: 6.1 Introduction 6.2 Requirements of injectable materials for tissue engineering 6.3 Injectable biomaterials: methods of gelation and tissue engineering applications 6.4 Injectable composites and applications in tissue engineering 6.5 Conclusion and future trends 6.7 Glossary Chapter 7: Vascular applications of injectable biomaterials Abstract: 7.1 Introduction 7.2 Embolization therapy for vascular conditions 7.3 Types of embolic materials 7.4 Future trends Chapter 8: Orthopaedic applications of injectable biomaterials Abstract: 8.1 Introduction 8.2 Classification 8.3 Clinical applications 1: fixation 8.4 Clinical applications 2: bone healing 8.5 Clinical applications 3: prevention and regeneration 8.6 Clinical applications 4: miscellaneous 8.7 Conclusion Chapter 9: Dental applications of injectable biomaterials Abstract: 9.1 Introduction 9.2 Challenges in the application of biomaterials to dentistry 9.3 Directly placed tooth-colored materials 9.4 Injectable materials in root canal therapy 9.5 Injectable calcium phosphate cements 9.6 Conclusion Chapter 10: Injectable polymeric carriers for gene delivery systems Abstract: 10.1 Introduction 10.2 Biological barriers 10.3 Nanoparticles 10.4 Microspheres 10.5 Hydrogels 10.6 Small interfering RNA (siRNA) 10.7 Conclusion 10.8 Acknowledgements Part III: Technologies and developments Chapter 11: Environmentally responsive injectable materials Abstract: 11.1 Introduction 11.2 Temperature-sensitive polymers 11.3 Electrically sensitive polymers 11.4 pH-sensitive polymers 11.5 Light-sensitive polymers 11.6 Biomolecular-sensitive polymers 11.7 Other stimuli-sensitive polymers 11.8 Conclusion and future trends Chapter 12: Injectable nanotechnology Abstract: 12.1 Introduction 12.2 Route of administration and biodistribution of injectable nano-carriers 12.3 Diagnostic applications of injectable nano-carriers 12.4 Therapeutic applications of injectable nano-carriers 12.5 Injectable nanomaterials as matrix precursors 12.6 Conclusions Chapter 13: Injectable biodegradable materials Abstract: 13.1 Introduction 13.