Inflammation in the Pathogenesis of Chronic Diseases: The COX-2 Controversy / Edition 1

by Randall E. Harris

Overview

In this book, a worldwide panel of leading experts discuss the role of inflammation in the pathogenesis of major chronic diseases and the current controversy regarding risk versus benefit of selective cyclooxygenase-2 (COX-2) inhibitors. The authors provide exciting and enlightening perspectives on COX-2 and related molecular targets in the future of medicine, including historical perspectives.

Product Details

ISBN-13:	9789048174294
Publisher:	Springer Netherlands
Publication date:	11/23/2010
Series:	Subcellular Biochemistry , #42
Edition description:	Softcover reprint of hardcover 1st ed. 2007
Pages:	324
Product dimensions:	6.10(w) x 9.25(h) x 0.03(d)

Table of Contents

Historical Perspectives.- Anti-Inflammatory Drugs in the 21st Century.- Inflammatory Mechanisms of Pathogenesis.- Nitric Oxide Synthase and Cyclooxygenase Interactions in Cartilage and Meniscus.- Obesity, Inflammation, and Vascular Disease.- Cyclooxygenase-2 (COX-2) and the Inflammogenesis of Cancer.- Role of COX-2 in Inflammatory and Degenerative Brain Diseases.- Inflammation and Cardiovascular Disease: The Coxib Controversy.- Cardiovascular Effects of the Selective Cyclooxygenase-2 Inhibitors.- COX-2 Inhibitors And Cardiovascular Risk.- A Biological Rationale for the Cardiotoxic Effects of Rofecoxib.- Cox-2 Blockade in Cancer Prevention and Therapy.- Cancer Chemoprevention by Cyclooxygenase 2 (COX-2) Blockade.- Strategies for Colon Cancer Prevention.- Inflammation and Neurodegenerative Disease.- NSAIDs for the Chemoprevention of Alzheimer’s Disease.- Inflammation in parkinson’s disease.- Nutrition, Inflammation and Chronic Disease.- Essential Polyunsaturated Fatty Acids, Inflammation, Atherosclerosis and Cardiovascular Diseases.- Nutritional Intervention in Brain Aging.

Editorial Reviews

Reviewer: Vladimir N Despotovic, MD (Washington University Medical Center)
Description: This is an up-to-date review of the current understanding of inflammation, the mechanisms by which it affects disease, and the role of anti-inflammatory medications pertaining to COX-2 and its inhibition.
Purpose: The purpose is to discuss in detail the current understanding of the role of inflammation in several common chronic diseases as well as the role of COX-2 and COX-2 related molecular targets and its inhibition with the current and future generations of anti-inflammatory drugs.
Audience: Physicians and researchers with a particular interest in the current research and understanding of inflammation and COX-2 inhibition are the intended readers. It is written by a panel of distinguished authors who contribute in their areas of research and expertise.
Features: This is a methodical review of the current understanding of inflammation on a molecular and clinical level in multiple disorders, including obesity, cancer, cardiovascular disease, inflammatory arthritis, and neurodegenerative disease with a particular emphasis on COX-2, its role, and its inhibition. A special section details COX-2 inhibitors and their cardiovascular effects. The greatest strength of this book is its exhaustive literature review and its fluid integration into a coherent unit. Historical perspective is often provided and the book concludes with new trends in nutrition research including polyunsaturated fatty acids and flavonoids and their effect on inflammation. Its limitations are the limited illustrations and fairly short index.
Assessment: This book presents expertly written, consolidated current research in certain aspects of inflammation. It covers both the basic science and clinical aspects of inflammation with an emphasis on COX-2 and related molecular targets. It is detailed, but written with great clarity and exhaustive references. It will be a great addition to any medical library.

Doody's Review Service

From the reviews: “This is an up-to-date review of the current understanding of inflammation, the mechanisms by which it affects disease, and the role of anti-inflammatory medications pertaining to COX-2 and its inhibition. … Physicians and researchers with a particular interest in the current research and understanding of inflammation and COX-2 inhibition are the intended readers. … It is detailed, but written with great clarity and exhaustive references. It will be a great addition to any medical library.” (Vladimir N. Despotovic, Doody’s Review Service, February, 2010)

From the Publisher