Immunopharmacology of the Gastrointestinal System

by John L. Wallace (Editor), Clive Page BSc, PhD, OBE, Hon FBPhS (Editor)

Overview

Diseases of the digestive system have a higher morbidity rate than any other group of disorder. There is a growing body of evidence that the immune system participates in the pathogenesis of a wide range of these diseases, including peptic ulcer disease and the gastropathy induced by nonsteroidal anti-inflammatory drugs (NSAIDS). For these reasons, efforts to develop novel therapies for digestive diseases are increasingly focused on the immune system. This volume reviews the immunopharmacology of the gastrointestinal tract at four distinct levels: Immunomodulation at a cellular level Cellular targers for immunomodulating drugs Specific classes of inflammatory mediators Utility and mechanisms of action of glucocorticoids in the treatment of diseases of the gastrointestinal tract.

Product Details

ISBN-13:	9781483289335
Publisher:	Elsevier Science
Publication date:	03/01/1993
Series:	Handbook of Immunopharmacology
Sold by:	Barnes & Noble
Format:	eBook
Pages:	198
File size:	5 MB

About the Author

Professor Clive P. Page, BSc PhD OBE HonFBPhS is a Professor of Pharmacology, King’s College London and Director of the Sackler Institute of Pulmonary Pharmacology, King’s College London. Clive’s main research interests are in the pharmacology of inflammation and respiratory disease and he has published over 250 scientific papers. Clive was the co-founder and previous Chairman of the Board of Verona Pharma plc, an AIM listed Company developing new drugs for the treatment of Respiratory Diseases. He is a Non Executive Director of and on boards of several companies. He was awarded the Society of Biology President’s Medal in 2012 for an outstanding contribution to the life sciences over the previous year. He is a Fellow of the Royal Society of Biology and an Honorary Fellow and President Elect of the British Pharmacological Society. In 2017, Clive was awarded an OBE for Services to Pharmacology.

Table of Contents

Contributors.
Series Preface.
Preface.
Neuromodulation of Gastrointestinal Immune and Inflammatory Responses, A.D. Befus.
Immunomodulation of the Gastrointestinal Epithelium, M.H. Perdue and D.M. McKay.
The Immune Modulation of Intestinal Motor Function, S.M. Collins.
Modulation of Neutrophil Function as a Mode of Therapy for GI Inflammation, I.S. Sandhu and M.B. Grisham.
The Vascular Endothelium in GI Inflammation, P.R. Kvietys and D.N. Granger.
Modulation of Mast Cell Function in the GI Tract, E.Y. Bissonnette and A.D. Befus.
Immuno-Pathophysiology of the Gastrointestinal Tract: Role of Platelet-Activating Factor, P. Kubes.
Cytokines, F. Cominelli
Immunopharmacology of Elcosanoids in the Gastrointestinal Tract, J.L. Wallace.
Nitric Oxide and the Gastrointestinal Tract, B.J.R.Whittle.
Glucocorticoids and Gastrointestinal Inflammation, L. Parente and K.G. Mugridge.
Glossary.
Key to Illustrations.
Index.