Imaginal Discs: The Genetic and Cellular Logic of Pattern Formation

by Lewis I. Held Jr

Overview

Many of the 14,000 genes of Drosophila are involved in the development of imaginal discs. These hollow sacs of cells make adult structures during metamorphosis, and their study is crucial to comprehending how a larva becomes a fully-functioning fly. This book examines the genetic circuitry of the well-known 'fruit fly', tackling questions of cell assemblage and pattern formation, of the hows and the whys behind the development of the fly. After an initial examination of the proximity versus pedigree imperatives, the book delves into bristle pattern formation and disc development, with entire chapters devoted to the leg, wing, and eye. Extensive appendices include a glossary of protein domains, catalogues of well-studied genes, and an outline of signaling pathways. More than 30 wiring diagrams among over 60 detailed schematics clarify the text. No student or practising scientist engaged in the study of Drosophila genetics should be without this comprehensive reference.

Product Details

ISBN-13:	9780521018357
Publisher:	Cambridge University Press
Publication date:	08/22/2005
Series:	Developmental and Cell Biology Series , #39
Edition description:	Revised ed.
Pages:	480
Product dimensions:	8.66(w) x 11.22(h) x 1.30(d)

Table of Contents

Preface; 1. Cell lineage versus intercellular signaling; 2. The bristle; 3. Bristle patterns; 4. Origin and growth of discs; 5. The leg disc; 6. The wing disc; 7. The eye disc; 8. Homeosis; Epilogue; Appendices; References; Index.

Editorial Reviews

"For the thousands of researchers working with Drosophila melanogaster, this seems like a book that should be on the shelf, ready to hand. Considering it is a hardcover and given the wealth of information that it contains, at just under $120, it seems like good value for the money."
Stephen Higgs, Entomological Society of America

From the Publisher