Human Cardiovascular Control / Edition 1

by Loring B. Rowell

Overview

This is a new and comprehensive analysis of reflex and hormonal control of the human cardiovascular system that grew out of Rowell's 1986 volume, Human Circulation: Regulation During Physical Stress, and incorporates more recent findings. The goal is to assist students, physiologists and clinicians to understand control of pressure, vascular volume, and blood flow by examining the cardiovascular system during orthostasis and exercise, two stresses that most affect these variables. These stresses are employed to analyze the passive properties of the vascular system and provide a basis for a detailed examination of how these properties are modified by mechanical, neural, and humoral factors. Interactive effects of the vasculature on cardiac performance are stressed to underline the importance of autonomic control supplemented by muscle pumping to maintain adequate ventricular filling pressure, particularly during exercise. Limitations in cardiac pumping ability, in oxygen diffusion from lungs to blood and from blood to active muscle, in metabolism, and in neural control of organ blood flow are analyzed to explain how total oxygen consumption is limited. The unsolved mystery is the nature of signals that govern the cardiovascular responses to exercise. This is discussed in a new and critical synthesis of ideas and evidence concerning the specific "error signals" that are sensed and then corrected by activation of cardiac and vascular effectors during exercise.

Product Details

ISBN-13:	9780195073621
Publisher:	Oxford University Press
Publication date:	01/14/1993
Edition description:	New Edition
Pages:	520
Product dimensions:	9.21(w) x 6.14(h) x 1.13(d)

About the Author

Loring B. Rowell is a Professor of Physiology and Biophysics and of Medicine (Cardiology) at the University of Washington School of Medicine. Dr. Rowell has published over 150 research papers, chapters, and review articles and has served on the editorial boeards of American Journal of Physiology, Circulation Research, and the Journal of Applied Physiology.

Table of Contents

1. n 12. Reflex Control During Orthostasis3. Neural-Humoral Adjustments to Orthostasis and Long-Term Control4. Orthostatic Intolerance5. Central Circulatory Adjustments to Dynamic Exercise6. Control of Regional Blood Flow During Dynamic Exercise7. Control of Blood Flow to Dynamically Active Muscles8. Cardiovascular Adjustments to Isometric Contractions9. Limitations to Oxygen Uptake During Dynamic Exercise10. What Signals Govern the Cardiovascular Responses to Exercise? Role of Central Command11. What Signals Govern the Cardiovascular Responses to Exercise? Reflexes from Active Muscles12. Arterial Baroreflexes, Central Command, and Muscle Chemoreflexes: A Synthesis

Editorial Reviews

Reviewer: James L. Ferguson, PhD (University of Illinois at Chicago College of Medicine)
Description: This book uses a whole-body integrative approach to understanding cardiovascular control. Two adaptive stimuli (i.e., gravity and exercise) are used to illustrate the multiple mechanisms that come together for cardiovascular regulation.
Purpose: A primary concern of this book is to ascertain what is being regulated to adapt the cardiovascular system to orthostasis and exercise. These two stresses are capable of initiating most if not all of the intrinsic homeostatic controls that the whole body possesses. Most of the author's objectives for this book were met.
Audience: This book was written for a broad audience (medical students, residents, graduate students, cardiologists, anesthesiologists, and specialists in aerospace and gravitational medicine and physiology). The author is liberal with the use of his own original scientific works, and at times this is at the expense of the ideas of other notable authors. This book is probably for the more sophisticated audiences that the author has targeted and not for the beginning medical or graduate student.
Features: There are 15 to 20 illustrations per chapter. In many instances the illustrations are component parts of a single study (e.g., chapter 4). In some instances the legends are not complete and the text does not clearly explain the figures. The reader then has to make assumptions as to which may or may not be correct. Many figures have more than five variables, which is time-consuming but not unusual when assessing cardiovascular function. References are current and relevant with many giving a historical perspective not found in many books. The index and table of contents are functional.
Assessment: This is a very worthwhile new book. It is a 'follow-up book' of a previous book by the author. Its approach to cardiovascular control using two different 'stressors' is quite workable. An interesting technique used by the author throughout the book is the use of descriptive findings of early scientists about phenomena that are still being investigated in modern laboratories. Probably the single most important message this text reinforces is that with adaptive responses to stressors (i.e., orthostasis and exercise) the cardiovascular outcome is related to the algebraic total of all the integrative functions.

Doody's Review Service

3 Stars from Doody

This book uses a whole-body integrative approach to understanding cardiovascular control. Two adaptive stimuli (i.e., gravity and exercise) are used to illustrate the multiple mechanisms that come together for cardiovascular regulation. "A primary concern of this book is to ascertain what is being regulated to adapt the cardiovascular system to orthostasis and exercise. These two stresses are capable of initiating most if not all of the intrinsic homeostatic controls that the whole body possesses. Most of the author's objectives for this book were met. "This book was written for a broad audience (medical students, residents, graduate students, cardiologists, anesthesiologists, and specialists in aerospace and gravitational medicine and physiology). The author is liberal with the use of his own original scientific works, and at times this is at the expense of the ideas of other notable authors. This book is probably for the more sophisticated audiences that the author has targeted and not for the beginning medical or graduate student. "There are 15 to 20 illustrations per chapter. In many instances the illustrations are component parts of a single study (e.g., chapter 4). In some instances the legends are not complete and the text does not clearly explain the figures. The reader then has to make assumptions as to which may or may not be correct. Many figures have more than five variables, which is time-consuming but not unusual when assessing cardiovascular function. References are current and relevant with many giving a historical perspective not found in many books. The index and table of contents are functional. "This is a very worthwhile new book. It is a 'follow-up book' of aprevious book by the author. Its approach to cardiovascular control using two different 'stressors' is quite workable. An interesting technique used by the author throughout the book is the use of descriptive findings of early scientists about phenomena that are still being investigated in modern laboratories. Probably the single most important message this text reinforces is that with adaptive responses to stressors (i.e., orthostasis and exercise) the cardiovascular outcome is related to the algebraic total of all the integrative functions.

James L. Ferguson