Table of Contents
Notes on Contributors vii
Preface to the First Edition ix
Preface to the Ninth Edition x
About the Companion Website xi
Part 1 Introducing Pharmaceutical Microbiology 1
1 Introduction to Pharmaceutical Microbiology 3 Brendan F. Gilmore and Stephen P. Denyer
Part 2 Biology of Microorganisms 11
2 Fundamental Features of Microbiology 13 Norman Hodges and Stephen P. Denyer
3 Bacteria 27 David Allison
4 Fungi 47 Kevin Kavanagh
5 Viruses and Other Acellular Infectious Agents: Characteristics and Control 63 Timofey Skvortsov and Jean-Yves Maillard
6 Protozoa 98 Tim Paget
Part 3 Pathogens and Host Response 121
7 Principles of Microbial Pathogenicity and Epidemiology 123 David Allison and Andrew J. McBain
8 Microbial Biofilms: Consequences for Health 135 Brendan F. Gilmore
9 Immunology 147 Mark Gumbleton and Mathew W. Smith
10 Vaccination and Immunisation 174 Gavin J. Humphreys and Andrew J. McBain
Part 4 Prescribing Therapeutics and Infection Control 191
11 Antibiotics and Synthetic Antimicrobial Agents: Their Properties and Uses 193 Brendan F. Gilmore
12 Mechanisms of Action of Antibiotics and Synthetic Anti-infective Agents 232 Peter Lambert
13 Bacterial Resistance to Antibiotics 249 Brendan F. Gilmore and Stephen P. Denyer
14 Clinical Uses of Antimicrobial Drugs 272 Hayley Wickens and Conor Jamieson
15 Antibiotic Prescribing and Antimicrobial Stewardship 289 Rebecca Craig
16 Infection Prevention and Control: Healthcare-associated Infection 304 Elaine Cloutman-Green
Part 5 Contamination and Contamination Control 321
17 Microbial Spoilage, Infection Risk and Contamination Control 323 Rosamund M. Baird
18 Chemical Disinfectants,Antiseptics and Preservatives 343 Sean P. Gorman and Brendan F. Gilmore
19 Laboratory Evaluation of Antimicrobial Agents 365 Brendan F. Gilmore and Sean P. Gorman
20 Microbicides: Mode of Action and Resistance 385 Stephen P. Denyer and Jean-Yves Maillard
21 Sterilisation Procedures and Sterility Assurance 403 Alistair K. Brown and Stephen P. Denyer
Part 6 Pharmaceutical Production 433
22 Sterile Pharmaceutical Products and Principles of Good Manufacturing Practice 435 Tim Sandle
23 The Manufacture and Quality Control of Immunological Products 462 Tim Sandle
24 Recombinant DNA Technology 480 Miguel Cámara and Stephan Heeb
Part 7 Current Trends and New Directions 507
25 The Wider Contribution of Microbiology to the Pharmaceutical Sciences 509 Mathew W. Smith, James C. Birchall and Sion A. Coulman
26 Alternative Strategies to Antibiotics: Priorities for Development 529 Brendan F. Gilmore
Index 544