Hormones

by Anthony W. Norman, Gerald Litwack

Overview

Hormones provides a comprehensive treatment of human hormones viewed in the light of modern theories of hormone action and in the context of current understanding of subcellular and cellular architecture and classical organ physiology.
The book begins with discussions of the first principles of hormone action and the seven classes of steroid hormones and their chemistry, biosynthesis, and metabolism. These are followed by separate chapters that address either a classical endocrine system, e.g., hypothalamic hormones, posterior pituitary hormones, anterior pituitary hormones, ,thyroid hormones, pancreatic hormones, gastrointestinal hormones, calcium regulating hormones, adrenal corticoids, hormones of the adrenal medulla, androgens, estrogens and progestins, and pregnancy and lactation hormones; or newer domains of hormone action which are essential to a comprehensive understanding of hormone action, including prostaglandins, thymus hormones, and pineal hormones. The book concludes with a presentation of hormones of the future, i.e., cell growth factors.
This book is intended for use by first-year medical students, graduate students, and advanced undergraduates in the biological sciences. It is also hoped that this book will fill the void that exists for resource materials for teaching cellular and molecular endocrinology and that it will be employed as an equal partner with most standard biochemistry textbooks to provide a comprehensive and balanced coverage of this realm of biology.

Product Details

ISBN-13:	9781483258102
Publisher:	Elsevier Science & Technology Books
Publication date:	06/28/2014
Sold by:	Barnes & Noble
Format:	eBook
Pages:	822
File size:	49 MB
Note:	This product may take a few minutes to download.

About the Author

Anthony W. Norman received his A.B. from Oberlin College in 1959, and an M.S. and Ph.D. in Biochemistry in 1961 and 1963, respectively, from the University of Wisconsin, Madison. Following postdoctoral work in Paul D. Boyer’s group at UCLA, in 1964 he joined the Department of Biochemistry at University of California, Riverside, as an Assistant Professor. From 1976 to 1981 he served as Chair of the department and currently holds a Presidential Chair and is a Distinguished Professor of Biochemistry and Biomedical Sciences. Dr. Norman has also been active for some 25 years in medical education on the UC-Riverside campus and at UCLA through participation in the UR/UCLA Program in Biomedical Sciences, of which he was Dean and Director from 1986 to 1991.

Dr. Norman's biomedical research career has focused on the mechanism of action of the vitamin D family of steroids. His chief contributions to these areas of cellular and molecular endocrinology have played a pivotal role in defining the boundaries of this research domain via discoveries that have opened new areas of investigation. The first of these was the discovery in 1968, and chemical characterization in 1971, of the hormonally active form of vitamin D, 1a,25(OH)2-vitamin D3. Subsequent achievements include the discovery and characterization of the nuclear receptor for 1a,25(OH)2D3, the clinical evaluation of 1a,25(OH)2D3 in renal osteodystrophy, articulation of the concept of the vitamin D endocrine system, the importance of 1a,25(OH)2D3 to insulin secretion and the discovery of a new rapid, nongenomic, signal transduction process for 1a,25(OH)2D3.

Dr. Norman has been the recipient of awards that include a Fulbright Fellowship, 1970; Public Health Service Career Development Award, 1970; Mead Johnson Award, American Institute of Nutrition, 1977; Ernst Oppenheimer Award, Endocrine Society, 1977; Visiting Lecturer Australian Society of Endocrinology, 1978; Visiting Faculty Member, Mayo Clinic, 1981; Prix Andre.

Dr. Gerald Litwack obtained M.S. and PhD degrees from the University of Wisconsin Department of Biochemistry and remained there for a brief time as a Lecturer on Enzymes. Then he entered the Biochemical Institute of the Sorbonne as a Fellow of the National Foundation for Infantile Paralysis. He next moved to Rutgers University as an Assistant Professor of Biochemistry and later as Associate Professor of biochemistry at the University of Pennsylvania Graduate School of Medicine. After four years he moved to the Temple University School of Medicine as Professor of Biochemistry and Deputy Director of the Fels Institute for Cancer Research and Molecular Biology, soon after, becoming the Laura H. Carnell Professor. Subsequently he was appointed chair of Biochemistry and Molecular Pharmacology at the Jefferson Medical College as well as Vice Dean for Research and Deputy Director of the Jefferson Cancer Institute and Director of the Institute for Apoptosis. Following the move of his family, he became a Visiting Scholar at the Department of Biological Chemistry of the Geffen School of Medicine at UCLA and then became the Founding Chair of the Department of Basic Sciences at the Geisinger Commonwealth School of Medicine, becoming Professor of Molecular and Cellular Medicine and Associate Director of the Institute for Regenerative Medicine at the Texas A&M Health Science Center as his final position. During his career he was a visiting scientist at the University of California, San Francisco and Berkeley, Courtauld Institute of Biochemistry, London and the Wistar Institute. He was appointed Emeritus Professor and/or Chair at Rutgers University, Thomas Jefferson University and the Geisinger Commonwealth School of Medicine. He has published more than 300 scientific papers, authored three textbooks and edited more than sixty-five books. Currently he lives with his family and continues his authorship and editorial work in Los Angeles.

Table of Contents

Preface

Chapter 1 General Considerations of Hormones

I. Classification of Hormones

II. Receptors for Hormones

III. Mechanisms of Hormone Action

IV. Evolution of Hormones

V. Physical Parameters of Hormone-Receptor Interactions

VI. Newer Developments Impacting on the Understanding of Hormone Action

VII. Summary

References

Chapter 2 Steroid Hormones: Chemistry, Biosynthesis, and Metabolism

I. Introduction

II. Chemistry of Steroids

III. Biosynthesis of Cholesterol

IV. Biosynthesis of Steroids

V. Properties of Enzymes Involved in Steroid Metabolism

VI. Catabolism and Excretion of Steroid Hormones

References

Chapter 3 Hypothalamic Regulating Hormones

I. Introduction

II. Anatomical, Morphological, and Physiological Relationships

III. Chemistry

IV. Biochemistry

V. Clinical Aspects

References

Chapter 4 Posterior Pituitary Hormones

I. Introduction

II. Anatomy, Development, and Fine Structure of the Posterior Pituitary

III. Chemistry

IV. Biochemistry

V. Biological and Molecular Actions

VI. Clinical Aspects

References

Chapter 5 Anterior Pituitary Hormones

I. Introduction

II. Anatomical, Morphological, and Physiological Relationships

III. Chemistry

IV. Biochemistry

V. Prolactin

VI. Growth Hormone

VII. ß-Lipotropin

VIII. Thyrotropic Hormone

IX. ACTH

X. Clinical Aspects

References

Chapter 6 Thyroid Hormones

I. Introduction

II. Anatomical and Morphological Relationships

III. Chemistry

IV. Biochemistry

V. Biological and Molecular Actions

VI. Clinical Aspects

References

Chapter 7 Pancreatic Hormones: Insulin and Glucagon

I. Introduction

II. Anatomical, Morphological, and Physiological Relationships

III. Chemistry

IV. Biochemistry

V. Biological and Molecular Actions

VI. Clinical Aspects

References

Chapter 8 Gastrointestinal Hormones

I. Introduction

II. Anatomical, Morphological, and Physiological Relationships

III. Chemistry and Biochemistry

IV. Biological and Molecular Actions

V. Clinical Aspects

References

Chapter 9 The Calcium-Regulating Hormones: Vitamin D, Parathyroid Hormone, Calcitonin

I. Introduction

II. Anatomical, Morphological, and Physiological Relationships

III. Chemistry and Biochemistry

IV. Biology and Physiological Significance

V. Clinical Aspects

References

Chapter 10 Adrenal Corticoids

I. Introduction

II. Anatomy, Development, and Cellular Fine Structure of the Adrenal Cortex

III. Chemistry and Biochemistry

IV. Biological and Molecular Actions

V. The Zona Reticularis and Dehydroepiandrosterone

VI. The Mineralocorticoid Hormone

VII. Clinical Aspects

References

Chapter 11 Hormones of the Adrenal Medulla

I. Introduction

II. Anatomical, Morphological, and Physiological Relationships

III. Chemistry

IV. Hormone Action and Biochemistry

V. Actions of Epinephrine

VI. Enkephalins

VII. Clinical Aspects

References

Chapter 12 Androgens

I. Introduction

II. Anatomical and Morphological Relationships of the Male Reproductive System

III. Chemistry, Biochemistry, and Biological Responses

IV. Physiological Relationships

V. Molecular Actions

VI. Clinical Aspects

References

Chapter 13 Estrogens and Progestins

I. Introduction

II. Anatomical and Morphological Relationships of the Female Reproductive System

III. Chemistry, Biochemistry, and Biological Responses

IV. Physiological Relationships

V. Biological and Molecular Actions

VI. Clinical Aspects

References

Chapter 14 Hormones of Pregnancy and Lactation

I. Introduction

II. Anatomical and Morphological Relationships

III. Chemistry, Biochemistry, and Biological Responses

IV. Cell Biology and Molecular Actions

V. Clinical Aspects

References

Chapter 15 Hormones of the Kidney

I. Introduction

II. Anatomical, Morphological, and Physiological Relationships

III. Homeostasis of Fluid, Electrolytes, and Blood Pressure

IV. Kallikreins and Kinins

V. Prostaglandins

VI. Erythropoietin

VII. Clinical Aspects

References

Chapter 16 Prostaglandins

I. Introduction

II. Chemistry

III. Biochemistry

IV. Biological Actions

V. Leukotrienes

VI. Clinical Aspects

References

Chapter 17 Thymus Hormones

I. Introduction

II. Anatomical and Morphological Relationships

III. Cell Biology

IV. Chemistry and Biochemistry

V. Biological and Molecular Actions

VI. Clinical Aspects

References

Chapter 18 Pineal Hormones

I. Introduction

II. Anatomy and Cell Biology

III. Chemistry

IV. Biochemistry

V. Biological and Molecular Actions

VI. Clinical Aspects

References

Chapter 19 Cell Growth Factors

I. Introduction

II. Anatomical Aspects

III. Chemistry

IV. Biochemistry

V. Clinical Aspects

References

Appendix A Compilation of Known Hormones in Higher Mammals and Humans

Appendix B Human Blood Concentrations of Major Hormones

Appendix C Clinically Relevant Endocrine Disorders

Appendix D Incidences of Principal Disease Diagnoses

Appendix E Summary of Nobel Prizes in Endocrinology and Related Fields

Appendix F The Genetic Code

Appendix G Amino Acid Abbreviations

Appendix H Units of Measurement in Biological Systems

Index

What People are Saying About This

From the Publisher

An up-to-date revision of this crucial introduction to hormones and signalling systems in humans

Editorial Reviews

5 Stars! from Doody

This book is an extraordinary textbook describing the biochemistry, physiology, cell biology, and molecular biology of hormones. "It is intended to cover the field of endocrinology. "The book is written primarily for graduate students in biochemistry and first year medical students of endocrinology, but it will be invaluable to clinicians wishing to understand the pathogenesis of endocrine disorders as well as researchers in the field of endocrinology. "I cannot help but compare it in terms of appearance, style, and quality to the classic works of Gene and Cell. This book, which covers the entire field of endocrinology, is written by just two authors. This allows for a uniform style and consistently high quality and clarity among chapters with no repetition of material. The illustrations are clear and didactic, however some of the cartoons that were reproduced from other sources are not as clear as in the original. Also a little color in the illustrations would make them more pleasing, but the cost of the book would probably increase. "This second edition comes 11 years after the first edition and is as up-to-date as textbooks can get. It includes a review of leptins and newer growth factors as well as the role of hormones in cancer. I would recommend the use of this textbook in all medical school courses in endocrinology and it should at least be available on the bookshelves of all medical school libraries, clinicians, and researchers of hormones.

Roy E. Weiss

A textbook and extensive reference for first-year medical students and graduate and advanced undergraduates in the biological sciences. Examines human hormones in light of the current theories of hormone action and the current understanding of subcellular and cellular architecture and classical organ physiology. Assumes a previous exposure to the fundamental areas of biochemistry, including enzymology and the structure and function of macromolecules and other bio-organics. Incorporates the many developments in the field since the 1987 edition. Annotation c. by Book News, Inc., Portland, Or.

Booknews

Reviewer: Roy E. Weiss, MD, PhD (University of Chicago Medical Center)
Description: This book is an extraordinary textbook describing the biochemistry, physiology, cell biology, and molecular biology of hormones.
Purpose: It is intended to cover the field of endocrinology.
Audience: The book is written primarily for graduate students in biochemistry and first year medical students of endocrinology, but it will be invaluable to clinicians wishing to understand the pathogenesis of endocrine disorders as well as researchers in the field of endocrinology.
Features: I cannot help but compare it in terms of appearance, style, and quality to the classic works of Gene and Cell. This book, which covers the entire field of endocrinology, is written by just two authors. This allows for a uniform style and consistently high quality and clarity among chapters with no repetition of material. The illustrations are clear and didactic, however some of the cartoons that were reproduced from other sources are not as clear as in the original. Also a little color in the illustrations would make them more pleasing, but the cost of the book would probably increase.
Assessment: This second edition comes 11 years after the first edition and is as up-to-date as textbooks can get. It includes a review of leptins and newer growth factors as well as the role of hormones in cancer. I would recommend the use of this textbook in all medical school courses in endocrinology and it should at least be available on the bookshelves of all medical school libraries, clinicians, and researchers of hormones.

Doody's Review Service

"This authorative textbook describes the biochemistry, cell biology, physiology and molecular biology of hormones...All chapters have been completely updated and revitalized." —Anticancer Research, 2015

From the Publisher