High-Yield Immunology / Edition 2

by Arthur G. Johnson PhD

Overview

This book extracts the most important information on immunology and presents it in a concise, uncluttered fashion to prepare students for USMLE. High-Yield™ means exactly that!

Product Details

ISBN-13:	9780781774697
Publisher:	LWW
Publication date:	09/03/2005
Series:	High-Yield Series
Edition description:	Second
Pages:	112
Product dimensions:	7.00(w) x 10.00(h) x (d)

Table of Contents

	Preface	vii
	Acknowledgments	viii
1	Overview	1
I	Synopsis	1
II	Concerns in Medicine	1
III	Host-Parasite Equilibrium	1
IV	Development of the Acquired Immune System	2
V	Clonal Selection Theory	4
2	Antigens	5
I	Definitions	5
II	Factors Determining Antigenicity	5
III	Examples of Antigens	5
3	Innate Immunity	7
I	Fundamental Characteristics	7
II	Defensive Mechanisms	7
III	Acute Phase Response (APR)	10
IV	Pathogen Recognition Systems	10
4	Antibodies	13
I	General Properties	13
II	IgG	15
III	IgM	17
IV	IgA	17
V	IgE	19
VI	IgD	19
5	Immunogenetics	20
I	Genetic Control of Immunoglobulin Chain Synthesis	20
II	Genetic Control of Human Leukocyte Antigens (HLAs)	20
III	Genetic Control of the T-Cell Antigenic Receptor (TCR)	24
6	Immunologic Assays	26
I	Overview	26
II	Protection Tests	26
III	Agglutination Tests	26
IV	Precipitation Reactions	27
V	Complement Fixation	29
VI	Fluorescent Antibody	31
VII	Western Blot	31
VIII	Cell Counting and Flow Cytometry	31
IX	Reverse Transcription Polymerase Chain Reaction (RT-PCR)	34
X	DNA Microarrays	34
7	The Immune Response	35
I	Humoral Immunity	35
II	Cell-Mediated Immunity (CMI)	39
8	Signal Transduction in Immune Cells	43
I	Effective Immune Responses Require Communication Between a Wide Range of Cell Types	43
II	Receptor Architecture and Fundamental Characteristics	44
III	Signaling Molecules	48
IV	Pathways	49
9	Inflammation	53
I	Introduction	53
II	Inflammation Process	53
III	Kinetics	55
IV	Mediators of Inflammation	55
10	Hypersensitivity Diseases	59
I	Overview	59
II	Anaphylaxis (Type I) Reactions	59
III	Cell Surface Antigen-Antibody (Ag-Ab) Cytotoxicity (Type II) Reactions	62
IV	Antigen-Antibody (Ag-Ab) Complex (Type III) Reactions	63
V	Delayed-Type Hypersensitivity (Type IV) Reactions	65
11	Immunodeficiency Diseases	66
I	Overview	66
II	Developmental Immunodeficiency Disorders	66
III	Acquired Immunodeficiency Syndrome (AIDS)	68
IV	Cytokine and Chemokine Deficiencies	70
V	Senescence (Aging) of the Immune Response	70
12	Autoimmune Disorders	71
I	Overview	71
II	Immunoregulation Breakdown	71
III	Systemic Autoimmune Disorders	72
IV	Organ-Specific Autoimmune Disorders	73
13	Immunologic Aspects of Transplantation	76
I	Histocompatibility	76
II	Complications of Organ Transplantation	77
III	Immunosuppression	78
14	Cancer Immunology	80
I	Definition	80
II	Oncogenes	80
III	Cancer and the Immune System	80
IV	Cancer Immunotherapy	81
15	Immunization	83
I	Overview	83
II	Specific Vaccines	84
III	Adjuvants	88
	Study Questions and Answers	89