ISBN-10:
1461444985
ISBN-13:
9781461444985
Pub. Date:
08/04/2012
Publisher:
Springer New York
Hereditary Retinopathies: Progress in Development of Genetic and Molecular Therapies / Edition 1

Hereditary Retinopathies: Progress in Development of Genetic and Molecular Therapies / Edition 1

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Overview

The hereditary retinopathy, retinitis pigmentosa (RP), which affects 1 in 3,500 people worldwide, is the most common cause of registered visual handicap among those of the working age in developed countries. RP is a highly variable disorder where patients may develop symptomatic visual loss in early childhood, while others may remain asymptomatic until mid-adulthood. Most cases of RP segregate in autosomal dominant, recessive or X-linked recessive modes, with approximately 41 genes being implicated in disease pathology to date (RetNet). The extensive genetic heterogeneity associated with autosomal dominant RP (adRP) is an undisputed hindrance to the development of genetically based therapeutics.


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Product Details

ISBN-13: 9781461444985
Publisher: Springer New York
Publication date: 08/04/2012
Series: SpringerBriefs in Genetics , #1
Edition description: 2012
Pages: 46
Product dimensions: 6.10(w) x 9.25(h) x 0.01(d)

Table of Contents

Preface.- Introduction.- Gene-based Medicines directly targeting genetic defects and molecular pathologies common to multiple forms of disease.- Molecular Medicines.

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