Table of Contents

1. Is there Clinical Relevance for Therapies which Disrupt the Metastatic Cascade?.- 2. Overview of the Metastatic Cascade.- 3. Overview on Blood Coagulation Proteins.- 4. The Microinjury Hypothesis and Metastasis.- 5. Hemostatic Abnormalities in Tumor-Bearing Animals.- 6. Evidence for a Tumor Proteinase in Blood Coagulation.- 7. Relationship between Procoagulant Activity and Metastatic Capacity of Tumor Cells.- 8. Fibrin Formation: Implications for Tumor Growth and Metastasis.- 9. Perspectives on the Role of Platelets in Hemostasis and Thrombosis.- 10. Mechanisms of Platelet Aggregation by Murine Tumor Cell Spheroids.- 11. Heterogenous Mechanisms of Tumor Cell-Induced Platelet Aggregation with Possible Pharmacological Strategy Toward Prevention of Metastases.- 12. Tumor Cysteine Proteinases, Platelet Aggregation and Metastasis.- 13. Arachidonate Metabolism in Platelets and Blood Vessels.- 14. Prostacyclin/Thromboxanes and Tumor Cell Metastasis.- 15. Evidence for Altered Arachidonic Acid Metabolism in Tumor Metastasis.- 16. Calcium Channel Blockers: Inhibitors of Tumor Cell-Platelet-Endothelial Cell Interactions.- 17. Evidence for the Antimetastatic Effects of Coumarin Derivatives.- 18. Mitogenic Stimulation of Tumor Cells by Platelet Derived Growth Factors.- 19. Role of the Vascular Endothelium in Hemostasis.- 20. The Cellular Interactions of Metastatic Tumor Cells with Special Reference to Endothelial Cells and their Basal Lamina-Like Matrix.- 21. Interaction of Tumor Cells with the Basement Membrane of Endothelium.- 22. Hemostatic Alterations in Cancer Patients.- 23. Historical Overview of Clinical Experience with Anticoagulant Therapy.- 24. Rationale for Anticoagulant Treatment of Cancer.- 25. The Design and Execution of Anticoagulant Therapy Trials in Cancer.- 26.Experimental and Clinical Experience with Pyrimido — Pyrimidine Derivatives in the Inhibition of Malignant Metastasis Formation.- 27. Current Clinical Trials with Anticoagulant Therapy in the Management of Cancer Patients.