Handbook of Drug Interactions: A Clinical and Forensic Guide / Edition 2

by Ashraf Mozayani, Lionel Raymon

Overview

Adverse drug reactions and interactions are still a major headache for healthcare professionals around the world. The US Food and Drug Administration's database recorded almost 300,000 serious adverse events in 2009 alone, of which 45,000 instances proved fatal. This updated new edition of the indispensable guide to drug interactions incorporates fresh research completed since the book's original publication by Humana Press in 2004. Additions include a new section on pharmacogenomics, a rapidly growing field that explores the genetic basis for the variability of responses to drugs. This new material reviews important polymorphisms in drug metabolizing enzymes and applies the findings to forensic interpretation, using case studies involving opiates as exemplars.

Existing chapters from the first edition have in most cases been updated and reworked to reflect new data or incorporate better tables and diagrams, as well as to include recent drugs and formulations. Recent references have been inserted too. The handbook features extra material on illicit drug use, with a new chapter tackling the subject that covers cocaine, amphetamines and cannabis, among others. The section on the central nervous system also deals with a number of drugs that are abused illicitly, such as benzodiazepines, opiates flunitrazepam and GHB, while so-called 'social' drugs such as alcohol and nicotine are still discussed in the book's section on environmental and social pharmacology. Focusing as before on detailed explanation and incorporating both pharmacokinetic and pharmacodynamic drug interactions, this book will continue to be a lodestar for health and forensic professionals as well as students.

Product Details

ISBN-13:	9781493958238
Publisher:	Springer-Verlag New York, LLC
Publication date:	08/23/2016
Edition description:	Softcover reprint of the original 2nd ed. 2012
Pages:	828
Product dimensions:	6.10(w) x 9.25(h) x 0.07(d)

Table of Contents

Pharmacogenetics in Clinical and Forensic Toxicology: Overdoses and Deaths.- Drug Interactions with Benzodiazepines: Epidemiologic Correlates with Other CNS Depressants and In Vitro Correlates with Inhibitors and Inducers of Cyhrome P450 3A4.- Antiepileptic Drugs.- Opioids and Opiates.- Tricyclic Antidepressant Drug Interactions.- Selective Serotonin Reuptake Inhibitors.- Antipsychotic Drugs and Interactions: Implications for Criminal and Civil Litigation.- Drugs of Abuse.- Cardiovascular Drugs.- Antimicrobial Drugs.- Nonsteroidal Anti-inflammatory Drugs, Disease-Modifying Antirheumatic Drugs, and Agents Used in Gout.- Food and Drug Interactions.- Pharmacokinetic and Pharmacodynamic Interactions Between Alcohol and Other Drugs.- Nicotine and Tobacco.- Anabolic Doping Agents.- Drug Interaction Litigation.- Psychotropic Medications and Crime: The Seasoning of the Prozac Defense.

Editorial Reviews

From the reviews of the second edition:

“This second edition outlines the most current information and highlights drugs of abuse while providing detailed information on the mechanisms of drug-drug interactions from a forensic toxicology perspective. … Any health or forensic professional could use this book to explain the underlying pharmacology of drug-drug interactions. … laboratory scientists conducting forensic analysis of drug interactions could use it to find thorough explanations of these interactions. … the book is an excellent reference for those professionals searching for underlying mechanisms of drug-drug interactions.” (Melissa M. Ranieri, Doody’s Book Reviews, March, 2012)

From the Publisher

4 Stars! from Doody

Reviewer: Melissa M. Potts, BS, PharmD (Temple University School of Pharmacy)
Description: This second edition outlines the most current information and highlights drugs of abuse while providing detailed information on the mechanisms of drug-drug interactions from a forensic toxicology perspective.
Purpose: This guide focuses on forensic medicine, where mechanisms of drug-drug interactions are emphasized. References to pharmacokinetic case studies describe drug interactions from a retrospective standpoint; drug levels and genotyping in these examples explain the potentially devastating consequences of drug-drug interactions. The very detailed information may be helpful to scientists and professionals searching for specific information on the mechanism of a drug-drug interaction. However, if a more clinical perspective is desired, this book may not be ideal.
Audience: Any health or forensic professional could use this book to explain the underlying pharmacology of drug-drug interactions. Perhaps laboratory scientists conducting forensic analysis of drug interactions could use it to find thorough explanations of these interactions. The book is well referenced and the toxicology studies help readers understand how drug interactions manifest in lethal drug levels, clinical effects, and patient outcomes.
Features: This book is unique in dedicating an entire chapter to drugs of abuse. Benzodiazepines, cocaine, marijuana, alcohol, and nicotine are included in this analysis and the book has detailed explanations of how these drugs interact with conventional medications. Pharmacokinetic and pharmacodynamic interactions are included, and tables and charts help readers to easily reference information. Well-designed studies on these illicit drugs are often difficult to find, so the book does an excellent job of thoroughly explaining drug interactions with these substances. Discussion of clinical manifestations and management of drug interactions is limited, but that is beyond the scope of this guide, which is truly focused on forensic analysis.
Assessment: The book thoroughly explains the mechanisms of drug-drug interactions, specifically highlighting the lethal consequences of these interactions with references to forensic case studies. From these examples, we can learn how drugs interact in the body and how certain patient genotypes can increase or decrease the risk of these interactions. Overall, this is a very interesting subject and the book is an excellent reference for those professionals searching for underlying mechanisms of drug-drug interactions.

Doody's Review Service