Genomic and Personalized Medicine: V1-2

by Elsevier Science

Overview

This two-volume set provides an in-depth look at one of the most promising avenues for advances in the diagnosis, prevention and treatment of human disease. The inclusion of the latest information on diagnostic testing, population screening, predicting disease susceptibility, pharmacogenomics and more presents this book as an essential tool for both students and specialists across many biological and medical disciplines, including human genetics and genomics, oncology, neuroscience, cardiology, infectious disease, molecular medicine, and biomedical science, as well as health policy disciplines focusing on ethical, legal, regulatory and economic aspects of genomics and medicine.


Volume One Includes:

Principles, Methodology and Translational Approaches, takes readers on the journey from principles of human genomics to technology, informatic and computational platforms for genomic medicine, as well as strategies for translating genomic discoveries into advances in personalized clinical care.


Volume Two Includes:

Genome Discoveries and Clinical Applications presents the latest developments in disease-based genomic and personalized medicine. With chapters dedicated to cardiovascular disease, oncology, inflammatory disease, metabolic disease, neuropsychiatric disease, and infectious disease, this work provides the most comprehensive guide to the principles and practice of genomic and personalized medicine.



* Contributions from leaders in the field provide unparalleled insight into current technologies and applications in clinical medicine.
* Full colour throughout enhances the utility of this work as the only available comprehensive reference for genomic and personalized medicine.
* Discusses scientific foundations and practical applications of new discoveries, as well as ethical, legal/regulatory, and social issues related to the practice of genomic medicine.

Product Details

ISBN-13:	9780080919034
Publisher:	Elsevier Science
Publication date:	11/11/2008
Series:	Genomic and Personalized Medicine
Sold by:	Barnes & Noble
Format:	eBook
Pages:	1558
File size:	47 MB
Note:	This product may take a few minutes to download.

About the Author

Dr. Ginsburg is the founding Director of the Center for Applied Genomics & Precision Medicine in the Duke Institute for Genome Sciences & Policy. He is also Professor of Medicine and of Pathology at Duke University Medical Center, Professor of Biomedical Engineering at Duke Pratt School of Engineering, and Co-Director of the Duke Translational Medicine Institute.

Huntington Willard is on the faculty of the Department of Human Genetics at the University of Chicago. Prior to this appointment, Willard was the President and Director of the Marine Biological Laboratory and Professor of Human Genetics at the University of Chicago. He was previously on the faculty at Duke University, where he was founding director of the university-wide Duke Institute for Genome Sciences & Policy from 2003 to 2014, the Nanaline H. Duke Professor of Genome Sciences, and the Arts & Sciences Professor of Biology & Genome Sciences.

Table of Contents

The full table of contents encompasses 101 detailed review articles from recognized experts in the following content structure:

PART 1. GENOME-BASED APPROACHES TO BIOLOGY AND MEDICINE; Genome-Based Platforms for Genomic and Personalized Medicine; Informatic and Computational Platforms for Genomic and Personalized Medicine; Principles of Human Genomics

PART II. TRANSLATIONAL APPROACHES IN GENOMIC AND PERSONALIZED MEDICINE; Policy Challenges in Genomic and Personalized Medicine; The Translation of Genomics into Medicine

PART III. DISEASE-BASED GENOMIC AND PERSONALIZED MEDICINE: GENOME DISCOVERIES: Cardiovascular Genomic Medicine; Infectious Disease Genomic Medicine; Inflammatory Disease Genomic Medicine; Metabolic Disease Genomic Medicine; Neuropsychiatric Disease Genomic Medicine; Oncology Genomic Medicine

What People are Saying About This

From the Publisher

Winner of a Highly Commended BMA Medical Book Award for Medicine

Editorial Reviews

"I found this book fascinating. The review of the variation in the human genome is outstanding, and the coverage of epigenetics is unique and extremely useful for an understanding of the influence of the environmental factors on gene behavior…The book includes carefully selected illustrations of excellent quality. This is a well-designed publication that readers will find inviting." Rating: 4 Stars—Doody.com, March 21, 2014 "The first volume covers the principles of human genomics and of genome-based approaches to medicine, as well as the enabling and integration of genomic strategies, clinical research, and informatics (including policy challenges). The 58 chapters in the second volume are devoted to the specifics of approaches to particular diseases— cardiovascular, cancer, inflammatory and metabolic, neuropsychiatric, and infectious."—Reference & Research Book News, October 2013 "Publication of this second edition of Genomic and Personalized Medicine 2^nd edition occurs roughly nine and half years  after the official completion of the Human Genome Project in April 2003. That monumental, international, and historic Project catapulted forward the fields of genetics and genomics at a pace that only the most optimistic scientific leaders realistically envisioned at that time. Indeed, it is truly stunning to consider what has been accomplished in the past nine-plus years, especially with respect to accomplishments relevant to genomic and personalized medicine. These ~100 chapters elegantly showcase the depth and breadth of this rapidly growing area of biomedicine. Once again, Ginsburg and Willard have recruited an impressive cast of geneticists and genomicists to contribute chapters spanning a wide spectrum of topics - from fundamentals in genomics research to key clinical areas that represent some of the ‘lowest hanging fruit’ in terms of opportunities to have genomics change medical practice. Together, these chapters provide unequivocal evidence about the current state of genomic and personalized medicine - that the opportunities are breathtaking, that the challenges are immense, and that the potential to improve health is nearly unlimited."—Eric Green MD, PhD, Director, NHGRI "This is the definitive textbook providing the content for a new era of medicine. An era where disease is defined at the molecular level rather than the anatomic level; where therapies are individualized and targeted rather than uniformly applied across a population. We have an opportunity with this text to improve patient outcomes using new tools and strategies, which is certainly an exciting prospect for each of us. This text should be mandatory reading for every physician, or physician in training."—Dietrich Stephan, President and CEO of Silicon Valley Biosystems, Co-Founder of Navigenics, Board of Directors of Personalized Medicine Coalition [on the first edition] "With genetic discoveries being published weekly, and increasing efforts to translate genomics to the clinic, there is a pressing need to educate medical students, physicians ad policy-makers on the emerging discipline of genomic medicine. This valuable book is first of its kind, offering a comprehensive overview of the field's foundations, applications to each area of medicine, and translation into clinical medicine and policy."—David Altshuler MD, PhD, Professor of Genetics and Medicine, Harvard Medical School, Massachusetts General Hospital

From the Publisher

Reviewer: Luis F Escobar, MD, MS (Peyton Manning Children's Hospital)
Description: This is the second edition of an introductory book on the concept of personalized medicine based on current genetic and genomic knowledge. It discusses the application of complex human genetic information to practical situations that will affect the way interactions such as environment and genes will be considered in the future. It follows an outstanding first edition published in 2009.
Purpose: The authors note that this book is designed to lay the foundation of personalized medicine by incorporating genomic-based analysis into clinical care. This is a worthy objective, limited only by the limited understanding of the human genome. Although we have completed the reading of the human genome, we are still in early stages of understanding the functionality and the intrinsic mechanisms that are involved in human life. Nevertheless, the material this book presents is unique and refreshing. The objectives are met at this particular time in history and stage of genomic knowledge.
Audience: Although the book is clearly written for readers at different levels of genetic education, it does require them to already be familiar with basic human genetics for them to be able to apply the concepts it presents. The complexity of subjects suggests that the book is appropriate for human geneticists, ethicists, medical genetics students, undergraduate professors of human genetics, and graduate students involved in the study of genomic concepts. It is written by a wonderful group of contributors
Features: I found this book fascinating. The review of the variation in the human genome is outstanding, and the coverage of epigenetics is unique and extremely useful for an understanding of the influence of the environmental factors on gene behavior. Surprisingly, a chapter on bioinformatics provides a look at how the impact of genomic medicine could influence personalized healthcare for individual patients, as well as the alignment of payors and providers. The book includes carefully selected illustrations of excellent quality. This is a well-designed publication that readers will find inviting.
Assessment: This is a unique book. It provides us with a novel perspective of genomic medicine and knowledge. Clearly, future editions would be well received.

Doody's Review Service