Genome Stability: DNA Repair and Recombination

by James Haber

Overview

Genome Stability: DNA Repair and Recombination describes the various mechanisms of repairing DNA damage by recombination, most notably the repair of chromosomal breaks. The text presents a definitive history of the evolution of molecular models of DNA repair, emphasizing current research. The book introduces the central players in recombination. An overview of the four major pathways of homologous recombinational repair is followed by a description of the several mechanisms of nonhomologous end-joining. Designed as a textbook for advanced undergraduate and graduate students with a molecular biology and genetics background, researchers and practitioners, especially in cancer biology, will also appreciate the book as a reference.

Product Details

ISBN-13:	9780815344858
Publisher:	Taylor & Francis
Publication date:	12/16/2013
Pages:	416
Sales rank:	849,421
Product dimensions:	8.30(w) x 10.80(h) x 0.60(d)

About the Author

James Haber is at Brandeis University, Biology Deptartment, USA.

Table of Contents

Chapter 1. Restarting DNA Replication by Recombination
Chapter 2. Double-strand Break Repair Pathways
Chapter 3. RecA/Rad51 and the Search for Homology
Chapter 4. Preparation of the RecA/Rad51 Filament
Chapter 5. Single-Strand Annealing
Chapter 6. Gene Conversion
Chapter 7. In vivo Biochemistry: Recombination in Yeast
Chapter 8. Break-induced Replication
Chapter 9. Sister Chromatid Repair
Chapter 10. Gene Targeting
Chapter 11. Site-specific Recombination
Chapter 12. Cytology and Genetics of Meiosis
Chapter 13. Molecular Events During Meiotic Recombination
Chapter 14. Holliday Junction Resolvases and Crossing-over
Chapter 15. Nonhomologous End-joining
Chapter 16. DNA Damage Checkpoints and Genome Instability

Editorial Reviews

Reviewer: Omer Iqbal, MD, FACC, FESC (Loyola University Medical Center)
Description: Given the rapid advances in genetic recombination essential for the viability of human cells, and the fact that defects in recombination and repair mechanisms are frequently associated with the loss of genetic integrity found in cancer cells, this book very nicely discusses a variety of recombination mechanisms that are used in different settings to repair broken and damaged chromosomes.
Purpose: The purpose is to explore the various mechanisms of repairing DNA damage by recombination, most notably the repair of chromosomal breaks. The book also provides a definitive history of the evolution of molecular models of DNA repair.
Audience: The intended audience is advanced undergraduate and graduate students, as well as researchers and practitioners, particularly in cancer biology, who can use it as a reference.
Features: In 16 chapters, the book discusses the central players in recombination. It provides an overview of the four major pathways of homologous recombinational repair followed by a description of the several mechanisms of nonhomologous end-joining. The last chapter discusses DNA damage checkpoints and genome instability. Several color figures enhance the understanding of a rather difficult subject.
Assessment: This is an excellent resource on the models of DNA repair and other important areas of gene targeting and DNA recombination in mitotic and meiotic cells for advanced undergraduate students, graduate students, researchers, and medical oncologists.

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