Genetic Models of Schizophrenia

by Akira Sawa (Editor)

Overview

This is a well-established international series that examines major areas of basic and clinical research within neuroscience (as well as emerging and promising subfields): neuroanatomy, neurophysiology, neuroimaging, neurobiology, neuropharmacology, neuroendocrinology, neuropathology, neuropsychiatry, and neurobehavior. This volume provides a thorough treatment of gene models of schizophrenia, presenting articles from leading contributors in this important area.

Product Details

ISBN-13:	9780080962238
Publisher:	Elsevier Science
Publication date:	11/10/2009
Series:	ISSN , #179
Sold by:	Barnes & Noble
Format:	eBook
Pages:	144
File size:	1 MB

Table of Contents

List of Contributors v

Preface vii

Section I Overview

1 Genetic animal models for schizophrenia: advantages and limitations of genetic manipulation in drosophila, zebrafish, rodents, and primates Akir Sawa 3

Section II Novel Techniques to Generate Genetic Models

2 Animal models for schizophrenia via in utero gene transfer: understanding roles for genetic susceptibility factors in brain development Atsushi Kamiya 9

3 Gene manipulation with of stereotaxic viral infection for psychiatric research: Spatiotemporal components for schizophrenia Anupamaa J. Seshadri Akiko Hayashi-Takagi 17

4 ENU-induced mutant mice for a next-generation gene-targeting system Yoichi Gondo Ryutaro Fukumura 29

5 Inducible and conditional transgenic mouse models of schizophrenia Mikhail V. Pletnikov 35

Section III Representative Models

6 NR1 knockdown mice as a representative model of the glutamate hypothesis of schizophrenia Amy J. Ramsey 51

7 Modeling excess striatal D2 receptors in mice Christoph Kellendonk 59

8 Differential function of phosphodiesterase families in the brain: gaining insights through the use of genetically modified animals Michele P. Kelly Nicholas J. Brandon 67

9 Gene models of schizophrenia: DISCI mouse models Hanna Jaaro-Peled 75

10 The sandy (sdy) mouse: a dysbindin-1 mutant relevant to schizophrenia research Konrad Talbot 87

Section IV Other than Rodents

11 Zebrafish: a model system to examine the neurodevelopmental basis of schizophrenia Jill A. Morris 97

12 Modeling schizophrenia in flies Katsuo Furukubo-Tokunaga 107

13 Primate models of schizophrenia: future possibilities Arthur A. Simen Ralph DiLeone Amy F.T. Arnsten117

Subject Index 127