The Genetic Basis of Male Infertility / Edition 1

by Ken McElreavey

Overview

Every year there are new and exciting developments in assisted human reproduction, but how much do we really know about the underlying causes of infertility? This volume explores recent progress in the understanding of the genetics of spermatogenesis and male infertility. Topics include fundamental advances and current problems in the development and function of the testis, an outline of clinical findings in male infertility and an overview of the role of the Y chromosome in male fertility. Comprehensive critiques of posttranscriptional control during spermatogenesis, mammalian meiotic sterility, and comparative genetics of human spermatogenesis from the perspective of yeast, Drosophila and mice provide a global overview of the field.

Product Details

ISBN-13:	9783642085543
Publisher:	Springer Berlin Heidelberg
Publication date:	12/16/2010
Series:	Results and Problems in Cell Differentiation , #28
Edition description:	Softcover reprint of hardcover 1st ed. 2000
Pages:	306
Product dimensions:	6.10(w) x 9.25(h) x 0.36(d)

About the Author

McElreavey, Ken (Institut Pasteur, Paris)

Table of Contents

Clinical Aspects of Male Infertility.- The Cell Biology and Molecular Genetics of Testis Determination.- Sertoli Cell-Germ Cell Interactions.- Leydig Cell Function and its Regulation.- Posttranscriptional Control of Male Infertility.- An Integration of Old and New Perspectives of Mammalian Meiotic Sterility.- Mutations of the Cystic Fibrosis Gene and Congenital Absence of the Vas Deferens.- Mihondrial Function and Male Infertility.- The Human Y Chromosome and Male Infertility.- Spermatogenesis and the Mouse Y Chromosome: Specialisation out of Decay.- The Comparative Genetics of Human Spermatogenesis: Clues From Flies and Other Model Organisms.