Gene Delivery Systems: Development and Applications

by Yashwant Pathak (Editor)

Overview

This unique volume in our Drugs and Pharmaceutical Sciences series covers the development of gene therapy today, the technology involved, clinical applications of siRNA, non-viral vector-based mRNA delivery using nanotechnology, and RNA based vaccines for treating the infectious diseases. It also presents the current application of the CRISPR/Cas9 gene-editing technique which has revolutionized genome editing and which was awarded the 2020 Nobel Prize in Chemistry. Several new drug delivery systems are explored for the applications of gene therapy. These are found to be useful in treating chronic illnesses, including cancer and infectious diseases.

Key Features:

• Overview of the development of gene therapy
• Provides the most up to date information on the development of gene therapy, from the technology involved to gene correction and genome editing
• Presents CRISPR gene therapy recent trends and applications
• Discusses siRNA, mRNA, and DNA plasmids

Product Details

ISBN-13:	9781032029726
Publisher:	CRC Press
Publication date:	08/26/2024
Series:	Drugs and the Pharmaceutical Sciences
Pages:	316
Product dimensions:	6.12(w) x 9.19(h) x (d)

About the Author

Dr. Yashwant Pathak completed a PhD in Pharmaceutical Technology at Nagpur University, India and EMBA & MS in Conflict Management from Sullivan University. He is Professor and Associate Dean for Faculty Affairs at College of Pharmacy, University of South Florida. Tampa, Florida. With extensive experience in academia as well as industry, he has more than 100 publications and 2 patent and 2 patent application, 20 edited books published, including 7 books in Nanotechnology and 6 in Nutraceuticals and drug delivery systems. Dr Yashwant Pathak is also a Professor of Global health with College of Public health at USF, and recently his student completed PhD in Global health on Homeopathy medicine and its efficacy, a survey of 1274 patients in Pune in India.

Table of Contents

Preface. About the Editor. List of Contributors. Overview of Development of Gene Therapy. Understanding the Technologies Involved in Gene Therapy. Gene Therapy and Gene Correction: Target, Progress and Challenges to Treat Human Diseases. Clinical Applications of siRNA. Human Genomics Projects, Gene Therapy and Precision Medicine. The Current State of Non-Viral Vector–Based mRNA Medicine Using Various Nanotechnology Applications. RNA-Based Vaccines for Infectious Disease. Conditional Replication of Oncolytic Virus Based on Detection of Oncogenic mRNA. Unilateral Ex Vivo Gene Therapy by GDNF in Neurodegenerative Diseases. Gene Therapy for Cancer Treatment: Recent Trends and Clinical Evidence. Gene Therapy for Retina and Eye Diseases. COVID-19 Vaccine Development and Applications. In Vivo Gene Therapy: AAV2 Vectors. Gene Therapy for Acquired Tissue Damage: Scope, Quality, Non-Clinical and Clinical Guidelines of Gene Therapy Medical Products. iMRI for Clinical Gene Therapy. Index.