G Proteins, Receptors, and Disease / Edition 1

by Allen M. Spiegel

Overview

More than a collection of review articles, G Proteins, Receptors, and Disease summarizes in depth the state of our knowledge today concerning not only how cells communicate via G-protein-coupled signal transduction processes, but also how defects in these proteins and their receptors can cause serious human disease involving many different organ systems. Written by leading investigators, each chapter describes in detail the structure and function of a particular G protein or receptor, outlines possible mutations, and discusses fully the molecular pathogenesis of associated diseases. Diagnostic and therapeutic implications are also discussed when relevant.

In its unique blend of cutting-edge basic science and clinical medicine, G Proteins, Receptors, and Disease offers deep insights into the physiological significance of this key signal transduction pathway, as well as into the molecular basis of diseases ranging from obesity to malignancy. The basic understanding of the complex signal transduction process achieved here provides a firm foundation for future efforts to prevent and cure these diseases.

Product Details

ISBN-13:	9781461272908
Publisher:	Springer-Verlag New York, LLC
Publication date:	10/09/2012
Series:	Contemporary Endocrinology , #6
Edition description:	Softcover reprint of the original 1st ed. 1998
Pages:	324
Product dimensions:	7.01(w) x 10.00(h) x 0.03(d)

About the Author

Spiegel, Allen M., MD (National Institute of Diabetes and Digestive and Kidney Diseases)

Table of Contents

1 Introduction to G-Protein-Coupled Signal Transduction and Human Disease.- 2 Albright Hereditary Osteodystrophy, Pseudohypopara-thyroidism, and Gs Deficiency.- 3 Gas-Activating Mutations: A Cause of Acromegaly, Thyroid Adenomas, Fibrous Dysplasia, and the McCune-Albright Syndrome.- 4 Ulcerative Colitis in Mice Lacking G?i2.- 5 G Proteins Regulating Insulin Action and Obesity: Analysis by Conditional, Targeted Expression of Antisense RNA in vivo.- 6 G;12- and G?3- Subunits of Heterotrimeric G Proteins : A Novel Family of Oncogenes.- 7 Hypo- and Hyperthyroidism Caused by Mutations of the TSH Receptor.- 8 Disorders Caused by Mutations of the Lutropin/ Choriogonadotropin Receptor Gene.- 9 Inactivating and Activating Mutations of the FSH Receptor Gene.- 10 Nephrogenic Diabetes Insipidus and Vasopressin Receptor Mutations.- 11 Disorders with Increased or Decreased Responsiveness to Extracellular Ca2+ Owing to Mutations in the Ca2+0-Sensing Receptor.- 12 Constitutively Active PTH/PTHrP Receptors Cause Jansen’s Metaphyseal Chondrodysplasia.- 13 Mutation of the Growth Hormone-Releasing Hormone Receptor in the little Mouse.- 14 Functional Variants of the MSH Receptor (MC1-R), Agouti, and Their Effects on Mammalian Pigmentation.- 15 ACTH Resistance Syndromes.- 16 Altering Adrenergic Signaling and Cardiac Function in Transgenic Mice.- 17 Dopamine Receptors in Human Disease: Lessons from Targeted Mouse Mutants.- 18 The—3-Adrenergic Receptor and Susceptibility to Obesity, the Insulin Resistance Syndrome, and Noninsulin-Dependent Diabetes Mellitus.

Editorial Reviews

4 Stars! from Doody

Written by experts in the field, this book is a collection of reviews covering the major topics in G protein molecular biology. The contributors summarize the current understanding of molecular defects involving G protein and G protein coupled receptors in human diseases and animal models. The stated purpose is to provide the reader with a complete review of the known molecular and genetic details of the G protein signal cascade and related disease. This objective is worthy; a single volume compilation of the current state of G protein related research will be a valuable resource for many researchers. The book meets the stated objective effectively, particularly because of the selection of experts who wrote the chapters. The appropriate audience is researchers in a variety of fields whose interests involve G protein and G protein coupled receptor molecular biology and diseases, as well as progressive clinicians who deal with certain genetic diseases. The authority of the contributors is undisputed. The chapters are quite up-to-date. Each chapter is truly a state-of-the-art description. For example, Vassart's chapter on "hypo-hyperthyroidism caused by mutations of the TSH receptor" and the chapter by Koch and Lefkowitz on "altering adrenergic signaling and cardiac function" are excellent. The contributors provide the reader with appropriate and clear illustrations that contribute to the ease of understanding the subject. The references cited are significant publications that represent important contributions to the molecular and genetic knowledge of this topic. The subject matter is clearly expressed and the enthusiasm of the contributors is tangible. This book is appropriate forpurchase by medical libraries, medical bookstores, and individuals as well. I would recommend it to those who would like to update their knowledge in the field of G proteins, G protein coupled receptors, signal transduction, and diseases.

Silvana Pannain

Written for molecular biologists, endocrinologists, and other scientists interested in the molecular pathophysiology of human disease, this book summarizes the processes by which cells communicate via G protein-coupled signal transduction and how defects in these proteins and their receptors can cause diseases involving many different organ systems. Eighteen chapters each describe the structure and function of a particular G protein or receptor and its possible mutations; therapeutic and diagnostics implications are discussed where appropriate. Annotation c. by Book News, Inc., Portland, Or.

Booknews

Reviewer: Silvana Pannain, MD (University of Chicago Medical Center)
Description: Written by experts in the field, this book is a collection of reviews covering the major topics in G protein molecular biology. The contributors summarize the current understanding of molecular defects involving G protein and G protein coupled receptors in human diseases and animal models.
Purpose: The stated purpose is to provide the reader with a complete review of the known molecular and genetic details of the G protein signal cascade and related disease. This objective is worthy; a single volume compilation of the current state of G protein related research will be a valuable resource for many researchers. The book meets the stated objective effectively, particularly because of the selection of experts who wrote the chapters.
Audience: The appropriate audience is researchers in a variety of fields whose interests involve G protein and G protein coupled receptor molecular biology and diseases, as well as progressive clinicians who deal with certain genetic diseases. The authority of the contributors is undisputed.
Features: The chapters are quite up-to-date. Each chapter is truly a state-of-the-art description. For example, Vassart's chapter on "hypo-hyperthyroidism caused by mutations of the TSH receptor" and the chapter by Koch and Lefkowitz on "altering adrenergic signaling and cardiac function" are excellent. The contributors provide the reader with appropriate and clear illustrations that contribute to the ease of understanding the subject. The references cited are significant publications that represent important contributions to the molecular and genetic knowledge of this topic.
Assessment: The subject matter is clearly expressed and the enthusiasm of the contributors is tangible. This book is appropriate for purchase by medical libraries, medical bookstores, and individuals as well. I would recommend it to those who would like to update their knowledge in the field of G proteins, G protein coupled receptors, signal transduction, and diseases.

Doody's Review Service

Winner of one of the Best 1998 Health Sciences Books Awards!

"The book meets the stated objective. . .[of] providing the reader with a complete review of the known molecular and genetic details of the G protein signal cascade and related diseases. . .Each chapter is truly a state-of-the-art description."4 Stars!-Doody's Health Sciences Book Review Journal

"...attractive in its presentation and well illustrated with good quality photographs. . .bibliographies are current and extensive. . .a pleasure to read. . .would complement every medical library and should be highly recommended to clinical and basic scientists."-European Journal of Endocrinology

"G Proteins, Receptors, and Disease is a volume worthy of a place on the bookshelf of anyone with a current interest in endocrine disease and GPCR-targeted approaches to therapeutics....it is refreshing to find a book that communicates just how much genomics-based research can accelerate understanding, not just of a discrete area of science, but of human disease."- Nature Medicine

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