G Protein Methods and Protocols: Role of G Proteins in Psychiatric and Neurological Disorders / Edition 1

by Ram K. Mishra, Glen B. Baker, Alan A. Boulton

Overview

03490-9, Hardcover, April 22, 1997,

G PROTEIN METHODS AND PROTOCOLS: Role of Proteins in Psychiatric and Neurological Disorders

Edited by

Ram K. Mishra, McMaster University, Hamilton, Ontario, Canada

Glen B. Baker, University of Alberta, Edmonton, Canada

Alan A. Boulton, University of Saskatoon, Canada

Combining the cutting-edge insights of leading basic and clinical investigators, G Protein Methods and Prools provides both critical reviews and detailed prools for studying the medical role played by G proteins and signal transduction in mental and neurological disease. The psychiatric and neurological disorders covered range from Parkinson's disease and schizophrenia to manic depression, drug addiction, and mood and anxiety disorders. The prools contain the latest methods and techniques for G protein analysis and application in research related to the central nervous system.

This new work marks a novel departure from books focused narrowly on the physical properties of G proteins in isolation. By providing detailed methods and techniques, this volume's front-line contributors bring out the implications of G protein signal transduction for psychiatric and neurological disorders. Practical and authoritative, G Protein Methods and Prools will surely prove a major practical resource for all neurochemists, neurologists, molecular biologists, pharmacologists, and psychiatrists seeking to study and better understand these disease states.

Product Details

ISBN-13:	9780896034907
Publisher:	Springer-Verlag New York, LLC
Publication date:	07/14/1997
Series:	Neuromethods , #31
Edition description:	1997
Pages:	433
Product dimensions:	6.10(w) x 9.25(h) x 0.04(d)

About the Author

Mishra, Ram K. (McMaster Univ); Baker, Glen B. (Univ of Alberta); Boulton, Alan A. (Univ of Saskatchewan)

The contributors represent the specialties of psychiatry, neuroscience, neurology, physiology, and psychiatry. Most come from universities and research institutes in six countries, including Canada, Japan, the U.S., and India. Institutions prominently represented include McMaster Univ, Kobe Univ, Wake Forest, and All India Institute of Medical Sciences.

Table of Contents

In Vitro Autoradiographic Localization of Receptor-Stimulated [35S]GTPγS Binding in Brain.- Small-Molecular-Weight G Proteins.- G Proteins in the Etiology and Treatment of Mental Disorders.- G Protein—- and—?-Subunits as Possible Mediators of Dopamine-D1:D2 Receptor Ligand Binding Interactions.- Modulation of G Proteins in Rat Striatum by Neuroleptic Drugs and a Peptidomimetic Analog of Pro-Leu-Gly-NH2.- G Proteins and Animal Models of Parkinson’s Disease.- Protein Kinase C as a Modulator of 5- HT1A and Dopamine- D2 Receptor Signaling.- Molecular Mechanisms of Opiate Addiction in the Nucleus Accumbens.- G Protein-Linked Opioid Receptors.- G Protein-Coupled melatonin receptors.- G Proteins in the Pathophysiology and Treatment of Mood and Anxiety Disorders.- Determination of Adenosine Receptor-G Protein Coupling.- G Proteins and Mood Disorders.- G Proteins in the Medial Temporal Lobe in Schizophrenia.- G Protein Abnormalities in Schizophrenia.

Editorial Reviews

Basic and clinical investigators critically review the literature and detail protocols for studying the medical role played by G proteins and cellular signaling in disorders such as Parkinson's disease, schizophrenia, manic depression, drug addiction, and mood and anxiety disorders. The protocols contain the current methods and techniques for G protein analysis and application in research related to the central nervous system. A sampling of specific topics reveals G proteins in the etiology and treatment of mental disorders, molecular mechanisms of opiate addiction in the nucleus accumbens, G protein-coupled melatonin receptors, and G proteins in the medial temporal lobe in schizophrenia. No index. Annotation c. by Book News, Inc., Portland, Or.

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