From Basic Immunology to Immune-Mediated Demyelination / Edition 1

by Gianvito Martino, Luciano Adorini

Overview

Morphological, physiological and pathological evidence demonstrates that ner- vous and immune systems interact not only in maintaining brain homeostasis, but also in causing neurological diseases. The studyofthese interactions repre- sents the basis on which neuroimmunologyhas grown during the years. At pre- sent, several neurological diseases are recognized to be caused by a derange- ment of the immune system in either its regulatory or effector functions. The main scope ofthis book, to discuss how an unbalanced immune system maylead to immune-mediated neurological diseases, is achieved in three parts. The first part provides an overview on how the immune system works. This is propaedeutical to understanding interactions between the immune and ner- vous systems, which are discussed in the second part. The third part of the book focuses on one particular area of neuroimmunology, the immune disor- ders leading to the damage of central and peripheral myelin. Given the opportunity to review first the immune system in itself and then how it operates during immune-mediated demyelinating disorders, we have tried to provide the reader with a basis for clearly understanding how interac- tions between the immune and nervous systems can be protective or pathoge- nic. This knowledge is a prerequisite for a rationale immune intervention tar- geting these disorders.

Product Details

ISBN-13:	9788847021792
Publisher:	Springer Milan
Publication date:	10/08/2012
Series:	Topics in Neuroscience
Edition description:	Softcover reprint of the original 1st ed. 1999
Pages:	315
Product dimensions:	6.10(w) x 9.25(h) x 0.03(d)

About the Author

Martino, Gianvito (San Raffaele Scientific Institute); Adorini, Luciano (Roche Milano Ricerche)

Table of Contents

1 - Protective Versus Harmful Responses and Immune Regulation.- 2 - Antigen Recognition and Autoimmunity.- 3 - Assembly and Function of Immunoglobulins During B Cell Development.- 4 - Pathogenetic Mechanisms of Autoimmunity.- 5 - Adhesion Receptors Involved in Leukocyte Functions.- 6 - The Endothelium of the Brain Microvasculature and the Organization of Intercellular Junctions.- 7 - Chemokines and Chemokine Receptors.- 8 - Th1/Th2 Cytokine Network.- 9 - Lymphocyte Trafficking in the Central Nervous System.- 10 - Antigen Presentation in the Central Nervous System.- 11 - Myelination of the Central Nervous System.- 12 - Genomic Screening in Multiple Sclerosis.- 13 - MHC and Multiple Sclerosis.- 14 - Cytokine Genes in Multiple Sclerosis.- 15 - Adhesion Molecules and the and Blood-Brain-Barrier in Multiple Sclerosis.- 16 - Non-Myelin Antigen Autoreactivity in Multiple Sclerosis.- 17 - Myelin Antigen Autoreactivity in Multiple Sclerosis.- 18 - Inflammation and Multiple Sclerosis: a Close Interplay.- 19 - Magnetic Resonance and Blood-Brain Barrier Dysfunction in Multiple Sclerosis.- 20 - Immunotherapies for Multiple Sclerosis.- 21 - Animal Models of Demyelination of the Central Nervous System.- 22 - MHC and Non-MHC Genetics of Experimental Autoimmune Encephalomyelitis.- 23 - Genetics of Hereditary Neuropathies.- 24 - Immunopathogenetic Role of Anti-Neural Antibodies in Demyelinating Dysimmune Neuropathies.- 25 - Treatment of Inflammatory Demyelinating Polyneuropathy.

Editorial Reviews

3 Stars from Doody

In this book the interactions between nervous and immune systems are described. Moreover, a discussion is provided of the development of several neurological disorders secondary to these interactions, especially the demyelinative ones. The purpose is to discuss how an unbalanced immune system may lead to immune-mediated neurological disorders. I think these are very worthy objectives. This book is targeted for practitioners and specialists in the field of neurology and neuroimmunology. The contributors are credible authorities in the subject matter of the book. The book is an overview of how the immune system works, and how derangement of these immunological disorders can lead to demyelinative diseases. I think the shortcoming of this book is the lack of colored illustrations. This book is an overview of immunological mechanisms; moreover, the interactions that could occur between the nervous and immune systems and how they can result in demyelinative disorders are covered.

Yaser Abdel Maksoud

Reviewer: Yaser Abdel Maksoud, MD (University of Illinois at Chicago College of Medicine)
Description: In this book the interactions between nervous and immune systems are described. Moreover, a discussion is provided of the development of several neurological disorders secondary to these interactions, especially the demyelinative ones.
Purpose: The purpose is to discuss how an unbalanced immune system may lead to immune-mediated neurological disorders. I think these are very worthy objectives.
Audience: This book is targeted for practitioners and specialists in the field of neurology and neuroimmunology. The contributors are credible authorities in the subject matter of the book.
Features: The book is an overview of how the immune system works, and how derangement of these immunological disorders can lead to demyelinative diseases. I think the shortcoming of this book is the lack of colored illustrations.
Assessment: This book is an overview of immunological mechanisms; moreover, the interactions that could occur between the nervous and immune systems and how they can result in demyelinative disorders are covered.

Doody's Review Service