Explorers of the Black Box: The Search for the Cellular Basis of Memory
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Explorers of the Black Box: The Search for the Cellular Basis of Memory
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Product Details
| ISBN-13: | 9781504034104 |
|---|---|
| Publisher: | Open Road Distribution |
| Publication date: | 06/28/2016 |
| Sold by: | Barnes & Noble |
| Format: | eBook |
| Pages: | 276 |
| File size: | 401 KB |
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Explorers of the Black Box
The Search for the Cellular Basis of Memory
By Susan Allport
OPEN ROAD INTEGRATED MEDIA
Copyright © 2001 Susan AllportAll rights reserved.
ISBN: 978-1-5040-3410-4
CHAPTER 1
The Sea Hare and the Scientist
A convention of neuroscientists is in many ways much like any other convention. There is perhaps a greater percentage of men, certainly more beards, and probably more casual dress — more blue jeans and shorts and fewer suits. But since neuroscientists — those scientists who study the brains of earthworms, humans, and everything in between — take great pleasure in uninterrupted shoptalk, the hall in which a meeting of brain scientists is held, like any room full of people who spend their days pursuing a common goal and engaged in similiar activities, is filled with the very loud, almost mechanical-in-its-constancy hum of many people talking at once.
Like any other group of professionals, neuroscientists have their own jargon. Their conversations are so full of technical terms and familiar words — spikes, fire, drive — to which they have assigned strange new meanings that it's easy to lose sight of the fact that they are about brains — about those tangles of billions of nerve cells that are the seat of all imagining, all emotions, all behavior, all curiosity about the nature of brains. Most of us have spent some time wondering how our brain works. Brain scientists spend their entire lives pondering it, looking for a way even to begin asking the question, How does the brain generate mind? The brain, after all, is so complex an organ and can be approached from so many different directions using so many different techniques and experimental animals that studying it is a little like entering a blizzard, the Casbah, a dense forest. It's easy enough to find a way in — an interesting phenomenon to study — but also very easy to get lost. Many intelligent men and women have gotten lost; they've spent a lifetime accumulating data and constructing theories that may have seemed extremely important in their time but that were soon forgotten, disproved or reinterpreted, swept into the pile of discarded hypotheses and data founded on erroneous assumptions — a pile that in the history of neuroscience is particularly large.
Brain scientists, a Canadian researcher once told me, are like the proverbial group of blind men trying to describe the elephant. The difference between the scientists and the blind men is that the scientists have so much more — entire careers and reputations, decades of their lives — invested in their particular view of the elephant, in their idea of which of the myriad phenomena of the brain they should study and how they should go about it. With few exceptions, the types of experiments neuroscientists perform demand what one has called an "impossible measure of patience." Every step of an experiment has an extremely high rate of failure; whatever story emerges from a laboratory does so very, very slowly.
"As long as the brain is a mystery," Ramón y Cajal, the great Spanish neuroanatomist, wrote at the turn of the century, "the universe, the reflection of the brain, will also be a mystery." Eighty years later, remarkable advances in brain research have yielded treatments and diagnostic techniques for a number of the brain's diseases, as well as a fairly good understanding of how a few of the structures of the brain are wired together, how a nerve cell transmits an electrical impulse, and how sensory information is first processed. The brain as a whole, though, is still fundamentally a mystery. Some neurobiologists hope that it will always remain one and that science (despite their own efforts to the contrary) will not cross what is often called the last frontier of understanding. But if an understanding of the brain contines to elude scientists, it will not be for want of trying.
The magnitude of the current attempt to understand the brain is nowhere more evident than at the annual meetings of the Society for Neuroscience, an organization with over 10,000 members from many different disciplines who share an interest in nerve cells and brains. At the 1984 meeting, held at the convention center in Anaheim, California, over 7,210 participants gathered to deliver or listen to more than 4,710 different presentations over a period of five days. Just the abstracts from the meetings formed two volumes about the size of the Manhattan telephone directory. On any given morning or afternoon, a convention goer has to choose from among over 40 sessions taking place simultaneously, each of which includes 12 to 26 short presentations. At any single moment, a physicist might describe the membrane biophysics of a particular type of nerve cell, while elsewhere a psychologist discusses the specific memory defect in a patient with alcoholism-related amnesia, a biochemist tells of the properties of a newly discovered neurotransmitter, a physiological psychologist talks about how information coming in through an animal's chemosensory receptors is processed by the brain, a pharmacologist presents data on the binding properties of an inhibitor of synaptic transmission, an invertebrate neurophysiologist explains the neural circuit that controls swimming in the leech, a developmental neurobiologist describes factors that enhance nerve cell growth, an anatomist reports on the migration patterns of neurons in the visual cortex during the embryonic development of rats, and so on and so on, multiplied many times over for five days.
It is, in fact, too much for a single brain, even the brain of a neuroscientist, to take in, and after just one day there is much talk among those present of being burned out or saturated. More and more time is spent in informal conversation in the halls. There, scientists exchange more details about their work and talk about results they don't yet feel sufficiently confident about to publish or present in a talk. Many of these private exchanges contain the stuff of next year's meeting and the one after that; others are concerned with jobs, tenure proceedings, positions that may be opening up, laboratory space and new labs under construction, department politics, new departments and directorships, grants and grantsmanship, government and nongovernment funding sources, whose work is respected, whose isn't.
"— has always impressed me with deep thinking," one neuroscientist replies when a colleague asks whom he would recommend to head a new neuroscience group at Johns Hopkins University.
"Yes, but he's probably being spoiled at Rockefeller University with all those computers. Why would he want to come to Hopkins?"
"Then you might think of —."
"He only models the brain," says the Johns Hopkins professor. "He doesn't actually do experiments, so people don't take him seriously."
Scientists who are just starting out in the competitive world of science are very concerned about the declining funds for basic research and about making a name for themselves.
"I suffer from a lack of attention," a Princeton professor tells two friends. "It's a trade-off. I like working with this new technique, but it's so new that no one else is using it."
"You'll be all right. You just need a good story to go with the work," one of the friends replies.
"Don't worry. As soon as you have some data, you'll get the attention," adds the other.
Because the 1984 meeting took place only a week after Secretary of Defense Caspar Weinberger suddenly banned the use of cats and dogs in research funded by the Department of Defense, many scientists were also talking about the threat that antivivisectionists pose to basic research. Some were afraid that the National Institute of Health, which funds 40 percent of the biomedical research and nearly two-thirds of basic university science in this country, would be the next to follow the animal-rights activists' suit.
"If we don't do something, we're going to lose everything," comments one scientist.
"We've been so sure that what we're doing is right that we haven't taken the time to convince the public."
"What would be really inhumane would be to ban basic research," runs one refrain.
Some joke that they are glad to know what kind of organism the Reagan administration did care about. A Vietnam veteran and paraplegic, who studies spinal-cord regeneration in cats, comes forward at a meeting on the use of animals in research to say, "Neuroscientists look self-serving when they talk about the benefits of animal research, but cripples don't. Basic research has a product to sell, and the public should be made aware of it."
There are many ironies in the increasingly heated debate over the use of live, anesthetized animals in research. Not the least among them is that scientists, a predominantly atheistic or agnostic group, are here drawing on the Judeo-Christian tradition, which holds that animals were put on the earth specifically for the use of man. Another is that no animal-rights activist in this country has failed to benefit from animal research, since it is the basis of more than 90 percent of all the new medical knowledge of the past century.
For neuroscientists, an especially difficult irony is that at the same time they are using animal brains to find out about human brains, they are finding out more and more about animals: their perceptive capabilities, their abilities to learn and adapt, the intricacies of their systems of communication. The erroneous but clear ideas as to which animals have minds, consciousness, and souls that guided the research of previous centuries no longer exist. Those issues are very much up in the air. So is the question of whether they should have any effect on animal research. Some neurobiologists view the question of animal rights as intimately tied up with that of consciousness; others argue that basic research is ethical, no matter what the mental capabilities and sensibilities of the animals, because it benefits mankind.
All one can say for sure, looking around at the amazing quantity of research presented at the neuroscience meetings, is that some will benefit mankind and some won't. The reason for this is not just that some scientists work on animals to find out about animals, about the tens of thousands of species we share this world with, while others work on animals with the direct aim of finding out more about humans. Rather, it's that research is a hit-and-miss endeavor. Some of it will contribute to the fund of useful scientific knowledge, but much of it will soon be forgotten or reinterpreted. Two sociologists of science, Jonathan and Stephen Cole, designed a study to see if the advance of science depends on the work of a few talented scientists or on the contributions of the rank and file. Their conclusion was that since most of the scientific papers published each year are cited only once or not at all, science would lose little or nothing if the vast majority had never been written. I asked Stephen Cole if he thought there was any reason why this study, which examined research in physics, might not apply to biology. He thought not. "I am convinced," he told me, "that the great bulk of publications in biology is trivial, meaningless; it doesn't add anything to anyone's knowledge."
When I expressed incredulity to a Texas physiologist over the number of presentations at the neuroscience meetings, he related the story of a Harvard professor who ended one of his courses with the bad news that half of what he had just taught his students would turn out to be erroneous or useless information. The very difficult part for the students, scientists, funding agencies, and the public alike, is that time provides the only sure way of telling the good half from the bad.
"Truth is the daughter, not of authority, but time," Francis Bacon remarked. Scientists know this, but it's a hard dictum to live by. A piece of scientific work can be disregarded either because it was no good or because other scientists never knew about it. So at the same time that history teaches scientists that much of what they do will be revised, reinterpreted, or forgotten, they must vigorously promote their work at professional meetings and bring it to the attention of their colleagues. The science writers Nicholas Wade and William Broad have explained the process in terms of Adam Smith's theory of how private greed can advance the public good. "Each scientist in the research forum tries to win acceptance for his own ideas or recipes: on balance, over time, the better recipe for dealing with nature generally prevails, so that the stock of useful knowledge grows steadily greater," they write in Betrayers of the Truth, their study of fraud in science. "The more vigorously that scientists pursue their own personal goals, the more efficiently does truth emerge from the competing claims."
Laypersons expect less rhetoric and more reasoned, objective behavior from scientists. Most tend to view science as the collective and rational vision of scientists; in doing so, they fail to see that scientists' choice of problems and their way of structuring experiments and interpreting data is every bit as personal as an artist's choice of subject matter, color, and brushstroke. And just as an artist tends to encounter diverging assessments of his work, so a scientist has to deal with opinions of his research that may range from "brilliant" to "trivial." This is not really so surprising, since a scientist, like an artist, must give an external structure to something that is largely invisible, but it runs counter to most commonly held notions of science. Jonathan and Stephen Cole designed another study to see if the peer-review system of the National Science Foundation was an old-boy network: they found no evidence that it was. What surprised them was that they also found very little consensus among the reviewers as to what research should be funded and what should not. The reviewers disagreed, the Coles concluded, because there was no general agreement as to what good science in their field is or should be.
You don't have to be in a group of scientists very long to realize that science, like most human endeavors, is highly stratified, that it has its lesser lights and its brightly shining stars. It also doesn't take very long to discover the stars — those scientists thought by a large number of their peers to be doing significant, original work. At the neuroscience meetings, young graduate students can be heard discussing the merits of some scientist's work in almost reverential tones; conference rooms fill up for the presentations of certain scientists, then empty shortly afterward; only a very select group of scientists are asked to chair symposia and give keynote speeches.
By the time the Columbia University investigator Eric Kandel stepped out onto the stage of the Anaheim auditorium to deliver one of the keynote speeches of the 1984 meeting before some seven thousand neuroscientists, he had already been honored once that evening. One of his students, Richard Scheller, had been given the Society for Neuroscience Young Investigator Award, one of the most prestigious awards in neurobiology (and one that Kandel himself had won), and Scheller's short acceptance speech was an emotional tribute of gratitude to his mentor. Kandel, an unprepossessing-looking figure in a wrinkled khaki suit, came out a little later and began, as he often does, with a rhetorical question, as simply delivered and difficult for a layperson to grasp as it was loaded with implications and meanings for the neurobiologist. "How does one move from the study of molecules and how they determine the differentiation of cells to the complex behavior of primates?" Kandel asked. Before a different audience, this energetic researcher who is well known for his ability to make his research on the brain accessible to nonscientists, might have begun, "What are the specific molecules that the brain uses to remember, to produce a mood, an emotion, an idea — the mind?" But to this audience of his peers, Kandel spoke in more-scientific terms.
"You can't go directly from the study of molecules to the study of behavior," he continued in his well-modulated voice with its thick Brooklyn accent. "You must look at nerve cells and their connections in between." As he talked, one of his hands began describing large circles in the air to a rhythm that mirrored the cadences of his speech. And while doing this, he paced from one end of the stage to the other, and back again.
To followers of Eric Kandel's twenty-five-year-old study of the physical basis of learning and memory, this speech held no big surprises. Like most of the presentations at a neuroscience meeting, it added only one or two small pieces to a large puzzle that might take years or decades to put together. For Kandel, the puzzle is a particularly fundamental and difficult one: How do we learn? How do the cells and circuits of the brain change to accommodate and store the new information that we get from experience, and how is that information retrieved and read out? Kandel is addressing these very complex questions in a simple experimental animal — a large, shell-less sea snail called Aplysia and known also, because of its long, thick tentacles, resembling a rabbit's ears and flabby posterior, as the sea hare. In no way can the sea hare be called a quick learner or an animal with a good memory, but Kandel has chosen it as his experimental animal because of the advantages of its nervous system, the fact that it is built, as one neurobiologist puts it, "like an old Philco radio, with simple circuits and large, easily identifiable parts."
(Continues...)
Excerpted from Explorers of the Black Box by Susan Allport. Copyright © 2001 Susan Allport. Excerpted by permission of OPEN ROAD INTEGRATED MEDIA.
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Table of Contents
Contents
Prologue,1. The Sea Hare and the Scientist,
2. Rethinking the Brain,
3. The Squishies and the Crunchies,
4. The Mind of the Snail,
5. The Rest of the Field,
6. The Manifold Neuron,
7. In Search of the Engram,
8. The Flip Side of Science,
9. Setting Priorities Straight,
10. A Scientific Melee,
Index,
Acknowledgments,