Experimental Models in Serotonin Transporter Research

by Allan V. Kalueff, Justin L. LaPorte

Overview

The serotonin transporter is a key brain protein that modulates the reuptake of the neurotransmitter serotonin from synaptic spaces back into the presynaptic neuron. This control over neuronal signalling makes it a prime area of neuroscientific study. In this book an international team of top experts introduce and explicate the role of serotonin and the serotonin transporter in both human and animal brains. They demonstrate the relevance of the transporter and indeed the serotonergic system to substrates of neuropsychiatric disorders, and explain how this knowledge is translated into valid animal models that will help foster new discoveries in human neurobiology. Writing for graduate students and academic researchers, they provide a comprehensive coverage of a wide spectrum of data from animal experimentation to clinical psychiatry, creating the only book exclusively dedicated to this exciting new avenue of brain research.

Product Details

ISBN-13:	9780521514873
Publisher:	Cambridge University Press
Publication date:	03/04/2010
Pages:	380
Product dimensions:	5.98(w) x 9.25(h) x 0.87(d)

About the Author

Allan V. Kalueff is Assistant Professor of Physiology in the Department of Physiology and Biophysics at the Georgetown University Medical Center, Washington DC, USA. His research has been recognized by numerous prestigious scientific awards, and has focused on the role of the serotonin transporter as a contributor to neuropsychiatric disorders in various animal models.

Justin L. LaPorte is a member of the Society for Neuroscience. His research at the National Institute of Mental Health (Bethesda, USA) employs behavioral pharmacology and molecular genetics approaches to elucidate the pathogenetic mechanisms of psychiatric disorders such as depression, anxiety, and obsessive-compulsive disorder, with a specific focus on the role of serotonin transporter.

Table of Contents

List of contributors vii

Preface: Focus on the serotonin transporter Allan V. Kalueff Justin L. Laporte ix

1 Presynaptic adaptive responses to constitutive versus adult pharmacologic inhibition of serotonin uptake Beth A. Luellen Tracy L. Gilman Anne Milasincic Andrews 1

2 Cellular and molecular alterations in animal models of serotonin transporter disruption: a comparison between developmental and adult stages Qian Li 43

3 Developmental roles for the serotonin transporter Antonio M. Persico 78

4 SERT models of emotional dysregulation Adam Tripp Etienne Sibille 105

5 The serotonin transporter and animal models of depression Daniela Popa Chloé Alexandre Joëlle Adrien Clément Léna 135

6 The serotonin transporter knock-out rat: a review Jocelien Olivier Alexander Cools Bart Ellenbroek Edwin Cuppen Judith Homberg 170

7 Wistar-Zagreb 5HT rats: a rodent model with constitutional upregulation/downregulation of serotonin transporter Lipa Cicin-Sain Branimir Jernej 214

8 The role of the serotonin transporter in reward mechanisms F. Scott Hall Ichiro Sora Maria T. G. Perona George R. Uhl 244

9 Modeling SERT ? BDNF interactions in brain disorders: single BDNF gene allele exacerbates brain monoamine deficiencies and increases stress abnormalities in serotonin transporter knock-out mice Justin L. Laporte Renee F. Ren-Patterson Dennis L. Murphy Allan V. Kalueff 270

10 Primate models in serotonin transporter research Khalisa N. Herman James T. Winslow Stephen J. Suomi 288

11 The role of serotonin transporter in modeling psychiatric disorders: focus on depression, emotion regulation, and the social brain Klaus-Peter Lesch 308

Index 353

Editorial Reviews

'… essential reading and reference material for any researcher working on neuroscience in the fields of medicine, psychology, pharmacology and developmental biology, particularly where animal models are being used to further understanding of human brain development and disorders. … Non-specialists interested in this field, and willing to grapple with some academically challenging reading will find material to both furnish increased understanding of the background to current research and stimulate them to further reading.' Pamela J. Speed, Journal of Biological Education

From the Publisher