Excitatory Amino Acids: From Genes to Therapy

by Peter H. Seeburg (Editor), Iris Bresink (Editor), Lechoslaw Turski (Editor)

Overview

In this book emerging questions of current glutamate research are addressed and new pathways which glutamte research may take in the future discussed. Since glutamate antagonists are still the major hope for the therapy of neurodegenerative disorders in humans, research activities dedicated towards the development of such novel drugs are the focus of public attention. The book comments on the most recent discoveries in the field of neuroprotection and neurodegeneration.

Product Details

ISBN-13:	9783662035986
Publisher:	Springer Berlin Heidelberg
Publication date:	12/08/2012
Series:	Ernst Schering Foundation Symposium Proceedings , #23
Edition description:	Softcover reprint of the original 1st ed. 1998
Pages:	210
Product dimensions:	0.00(w) x 0.00(h) x (d)

Table of Contents

1 Glutamate Receptor Channels, RNA Editing, and Epilepsy.- 2 Regulation of Glutamate Receptor Gene Expression in Global Ischemia.- 3 Factors Regulating Excitotoxic Neurodegeneration: The Role of Calcium and the Mihondria.- 4 Excitotoxicity, Genetics, and Neurodegeneration in Amyotrophic Lateral Sclerosis.- 5 NO-NMDA Receptor Interactions: A Neuromolecular Approach to Novel Therapeutics.- 6 Glutamate in Neurodegenerative Disorders: Phenotype Resulting from Decreased Expression of AMPA Receptor GIuR-B Subunit mRNA in Rats.- 7 Quantitative Estimation of NMDA Receptor-Mediated Ca2+ Entry in Central Neurons.- 8 Calcium Permeability of Glutamate-Gated Channels in the CNS: Functional Role of the Ca2+-Permeable AMPA Receptor Channels.- 9 Localisation and Surface Expression of the AMPA Receptor Subunit GluR1 Using Green Fluorescent Protein and Anti-Peptide Antibodies.- 10 Input- and Output-Specific Segregation of Amino Acid Neurotransmitter Receptors on the Surface of Central Neurones.- Previous Volumes Published in this Series.