Epigenetics in Human Disease

by Trygve O Tollefsbol (Editor)

Overview

Epigenetics in Human Disease, Second Edition examines the diseases and conditions on which we have advanced knowledge of epigenetic mechanisms, such as cancer, autoimmune disorders, aging, metabolic disorders, neurobiological disorders and cardiovascular disease. In addition to detailing the role of epigenetics in the etiology, progression, diagnosis and prognosis of these diseases, novel epigenetic approaches to treatment are also explored. Fully revised and up-to-date, this new edition discusses topics of current interest in epigenetic research, including stem cell epigenetic therapy, bioinformatic analysis of NGS data, and epigenetic mechanisms of imprinting disorders.

Further sections explore online epigenetic tools and datasets, early-life programming of epigenetics in age-related diseases, the epigenetics of addiction and suicide, and epigenetic approaches to regulating and preventing diabetes, cardiac disease, allergic disorders, Alzheimer’s disease, respiratory diseases, and many other human maladies.

• Includes contributions from leading international investigators involved in translational epigenetic research and therapeutic applications
• Integrates methods and applications with fundamental chapters on epigenetics in human disease, along with an evaluation of recent clinical breakthroughs
• Presents side-by-side coverage of the basis of epigenetic diseases and treatment pathways
• Provides a fully revised resource covering current developments, including stem cell epigenetic therapy, the bioinformatic analysis of NGS data, epigenetic mechanisms of imprinting disorders, online epigenetic tools and datasets, and more

Product Details

ISBN-13:	9780128123294
Publisher:	Elsevier Science
Publication date:	05/18/2018
Series:	Translational Epigenetics , #6
Sold by:	Barnes & Noble
Format:	eBook
Pages:	1110
File size:	72 MB
Note:	This product may take a few minutes to download.

About the Author

Dr. Tollefsbol is a Distinguished Professor of Biology and a Senior Scientist in the O’Neal Comprehensive Cancer Center, Integrative Center for Aging Research, Nutrition Obesity Research Center, University Wide Microbiome Center, and the Comprehensive Diabetes Center at the University of Alabama at Birmingham (UAB). He is Director of the UAB Cell Senescence Culture Facility which he established in 1999. Dr. Tollefsbol trained as a Postdoctoral Fellow and Assistant Research Professor with members of the National Academy of Science at Duke University and the University of North Carolina. He earned doctorates in molecular biology and osteopathic medicine from the University of North Texas Health Sciences Center and his bachelor’s degree in Biology from the University of Houston. He has received prior funding from the NCI, NHLBI, NIMH and other federal institutes as well as the Glenn Foundation for Medical Research, Susan G. Komen for the Cure, the American Federation for Aging Research (AFAR), and the American Institute for Cancer Research (AICR) among many other sources.

Table of Contents

Section I: Introduction 1. Epigenetics in Human Disease

Section II: Methodology 2. Methods and Strategies to Determine Epigenetic Variation in Human Disease 3. Age Estimates Using DNA Methylation Patterns 4.Bioinformatics of Epigenetic Data Generated from Next-generation Sequencing

Section III: Human Cancer 5. DNA Methylation Alterations in Human Cancers 6. Alterations of Histone Modifications in Cancer 7. MicroRNA in Cancer 8. Epigenetic Approaches to Cancer Therapy

Section lV: Neurological Disease 9. Epigenomics in Neurobehavioral Disease 10. Emerging Role of Epigenetics in Human Neurodevelopmental Disorders 11. The Epigenetics of Alzheimer’s and Other Neurodegenerative Disease 12. Epigenetic Modulation of Human Neurobiological Disorder

Section V: Autoimmune Disease 13. Epigenetic Basis of Autoimmune Disorders in Humans 14. Approaches to Autoimmune Diseases Using Epigenetic Therapy

Section VI: Metabolic Disorders 15. Epigenomic Factors in Human Obesity 16. Epigenetic Approaches to Control Obesity 17. Epigenetics of Diabetes in Humans 18. The Potential of Epigenetic Compounds in Treating Diabetes

Section VII: Other Disorders/Diseases 19. Epigenetic Aberrations in Human Allergic Diseases 20. Therapy of Airway Disease: Epigenetic Potential 21. The Role of Epigenetics in Cardiovascular Disease 22. Epigenetic Treatment Approaches to Cardiovascular Disease 23. Epigenetics and Human Infectious Diseases 24. Therapy of Infectious Diseases Using Epigenetic Approaches 25. The Epigenetics of Endometriosis 26. Epigenetic DNA Methylation in Endometrial Cancer 27. Epigenetic Treatment Prospects of Gynecological and Reproductive Diseases

Section VIII: Development, Aging and Transgenerational Effects 28. Epigenetics of Transgenerational Inheritance in Disease 29. Epigenetic Mechanisms of Human Imprinting Disorders 30. Therapeutic Approaches to Imprinting Diseases 31. Stem Cell Epigenetics and Human Disease 32. Non-coding RNA Regulatory Networks, Epigenetics, and Programming Stem Cell Renewal and Differentiation: Implications for Stem Cell Therapy 33. Aging and Disease: The Epigenetic Bridge 34. Epigenetic Programming of Human Disease and Aging

Section lV: Future Research 35. Future Directions in the Epigenetics of Human Disease

What People are Saying About This

From the Publisher

A comprehensive resource examining the epigenetic basis of all major disease types, from basic disease biology to clinical translation and methods driving future research

Editorial Reviews

Reviewer: Luis F Escobar, MD, MS (Peyton Manning Children's Hospital)
Description: The title of this book is self-descriptive and accurate. It is a compilation of the current knowledge about the important role epigenetics plays in the causation of common human disorders. The author has identified a unique subject that is well covered by a variety of international authors.
Purpose: The purpose is to review those disorders or conditions for which there is considerable epigenetic evidence such as cancer, autoimmune disorders, and aging. In addition, it presents the current understanding of epigenetic influences on diabetes, neurologic disorders, and cardiovascular disease.
Audience: Medical geneticists in general would be a very receptive audience for this wonderful book. It is appropriate for clinical geneticists, genetics counselors, and basic scientists, as well as early undergraduate and graduate students interested in epigenetics. In addition, the clarity of presentation should make this book of interest to lay persons wishing to understand the interaction between nontraditional genetics and the origin of such disorders as obesity, cancer, and autoimmune disease.
Features: The format of this book is strikingly refreshing. It is accessible and very easy to read. An extremely useful introductory chapter is not only informative, it also provides an excellent base for understanding the rest of the book. Chapters can be read independent of one another, and the content of a chapter can be easily determined by scanning the chapter index that begins each one. Although there are not many illustrations, they are well thought out and of high quality.
Assessment: Congratulations are due to Dr. Tollefsbol and the team of authors — their work is timely and this book is a great accomplishment.

Doody's Review Service

"This volume constitutes a comprehensive survey of the emerging field of epigenetics in the etiology, progression, diagnosis, prognosis and treatment of human diseases… With its translational focus, this book will serve as valuable reference for both basic scientists and clinicians alike." —Anticancer Research, Volume 33, Issue no. 5, May 2013

"This book covers a huge range of topics, from early life effects on adult disease to epigenetic changes occurring with aging and senescence. Especially pertinent are the several chapters on epigenetic treatments for disease including drugs, miRNA/siRNA, natural substances and foods. With up to date coverage of an ever expanding field, Epigenetics in Human Disease will be a great resource for clinicians, researchers and students." —Craig Cooney, Investigator, Research Service, Veteran's Affairs Medical Center, Little Rock, AR & Affiliate Scientist, Nanotechnology Center, University of Arkansas, Little Rock, AR

From the Publisher