Enzymology and Molecular Biology of Carbonyl Metabolism

by H. Weiner, D. W. Crabb, T. G. Flynn

Overview

This is the 13th volume in the Enzymology and Molecular Biology of Carbonyl Metabolism series. Within the text, the reader is given further valuable insight into Carbonyl Metabolism. This collection is the largest in its field of study and provides the deepest look into just three gene families. Through dozens of articles, molecular biological techniques are discussed, examining ways in which they are influencing the direction of research on Aldehyde Dehydrogenase, Alcohol Dehydrogenase, and Reductases.

Product Details

ISBN-13:	9780306443572
Publisher:	Springer-Verlag New York, LLC
Publication date:	03/01/1993
Series:	Advances in Experimental Medicine and Biology Series , #32
Pages:	654
Product dimensions:	6.69(w) x 10.24(h) x (d)

About the Author

Henry Weiner is a professor of Biochemistry at Purdue University. Dr Weiner obtained his Ph.D. from Purdue University in 1963. His area of study currently includes protein trafficking and the enzymology of aldehyde dehydrogenasess.

Table of Contents

Aldehyde Dehydrogenases
Can We Change the Rate-Limiting Step of an Aldehyde Dehydrogenase?   Henry Weiner   Kwok Ki Ho     3
Unexpected Encounters in Simulations of the ALDH Mechanism   John Hempel   Hugh B. Nicholas Jr.   Shawn T. Brown   Troy Wymore     9
Inhibitory Effects of Disulfiram and Its Metabolites on Pseudomonas aeruginosa Betaine Aldehyde Dehydrogenase and Growth   Victor J. Zaldivar-Machorro   Patricia Demare   Maria R. Ramirez   Ignacio Regla   Rosario A. Munoz-Clares     14
Reversible Inactivation of Mitochondrial Aldehyde Dehydrogenase through Post-Translational Modifications in Hepatoma Cells and Alcohol-Fed Rat Livers   Kwan-Hoon Moon   Bong-Jo Kim   Jie Wan   Young-Mi Lee   Mohamed A. Abdelmegeed   Byoung-Joon Song     22
Inhibition of Mitochondrial Aldehyde Dehydrogenase-Mediated Oxidation of 3,4-Dihydroxyphenylacetaldehyde   Virginia R. Florang   Jennifer N. Rees   Nicole K. Brogden   David G. Anderson   Jonathan A. Doorn     33
Trans-4-hydroxy-2-nonenal (HNE), a Biochemical Tool (...as Well as a Toxin)   Jiri Brichac   Ales Honzatko   Laura Leiphon   Matthew J. Picklo     40
Detoxification of Chloroacetaldehyde byHuman Class-9 Aldehyde Dehydrogenase (ALDH9A1)   Mohammad Salad   Rainer Grant   Alexander Reberg   Lakshmaiah Sreerama     44
Identification of Polymorphic Human Class-3 Aldehyde Dehydrogenases   Lakshmaiah Sreerama   Rainer Grant   Bari Revee   Aaron Gross   Daniel D. Gregory     53
Phylogenetic and Structural Relationships of the Betaine Aldehyde Dehydrogenases   Adriana Julian-Sanchez   Hector Riveros-Rosas   Leon P. Martinez-Castilla   Roberto Velasco-Garcia   Rosario A. Munoz-Clares     64
Ionic Strength Dependency of Urea Effect on Renal Betaine Aldehyde Dehydrogenase Stability   Hector G. Ayala-Castro   Elisa M. Valenzuela-Soto     77
Effects of Monovalent Cations on the Structure and Thermal Stability of Betaine Aldehyde Dehydrogenase from Pseudomonas aeruginosa   Georgina Garza-Ramos   Ernesto Carrillo-Nava   Miguel Costas   Carlos Mujica-Jimenez   Roberto Velasco-Garcia   Rosario A. Munoz-Clares     83
ALDH3A1 Expression Is Modulated by Docosahexaenoic Acid through Peroxisome Proliferator-Activated Receptors (PPARs) in Human Lung Adenocarcinoma Cells   R. A. Canuto   M. Maggiora   G. Martinasso   M. Oraldi   V. Vasiliou   A. Trombetta   G. Muzio     91
The "Asian" Variant Equivalent of Yeast Aldehyde Dehydrogenase Can Inactivate the Active Yeast Enzyme in vivo: A Knock-in Type Experiment Using Yeast to Mimic Liver Cells   Abhijit Mukhopadhyay   Bao-Xian Wei   Henry Weiner     99
A Hepatocyte Inflammation Model for Carbonyl Induced Liver Injury: Drugs, Diabetes, Solvents, Chlorination   Peter J. O 'Brien   Shahrzad Tafazoli   Katie Chan   Mariam Mashregi   Rhea Mehta   Nandita Shangari     105
Therapeutic Intracellular Targets for Preventing Carbonyl Cell Death with B Vitamins or Drugs   Rhea Mehta   Peter J. O'Brien     113
Alcohol Dehydrogenases
Recombinant Mouse Alcohol Dehydrogenase 1: Kinetic Mechanism, Substrate Specificity and Oxidation of 20-Hydroxyeicosatetraenoic Acid   Bryce V. Plapp   Hirekodathakallu V. Thulasiram   Kristine B. Berst   Terry L. Kaduce     123
Functional Roles of Alcohol Dehydrogenases in Human Ethanol Metabolism   Shih-Jiun Yin   Shou-Lun Lee   Chung-Tay Yao   Ching-Long Lai     134
Kinetic Analysis of SDRs, ADHs and AKRs toward Free and CRBPI-bound Retinoids: Effect of Tween-80 and Microsomal Membranes   Oriol Gallego   Olga V. Belyaeva   Sergio Porte   F. Xavier Ruiz   Anton V. Stetsenko   Elena V. Shabrova   Natalia V. Kostereva   Silvia Martras   Xavier Pares   Natalia Y. Kedishvili   Jaume Farres     144
Structural and Functional Features of Cinnamyl Alcohol Dehydrogenase (Adh6p) from Saccharomyces cerevisiae   Carolina Larroy   Eva Valencia   Ignacio Fita   Xavier Pares   Josep A. Biosca     152
Diversity of Beta-Hydroxyacid Dehydrogenases in Plants   John W. Hawes     160
Carbonyl Reductases
Multifunctional Carbonyl Reductases of the Short-Chain Dehydrogenase/Reductase (SDR) Superfamily in Mammalian Species   Edmund Maser   Frank Hoffmann     169
The Aldo-Keto Reductase Superfamily Homepage: 2006 Update   Jason E. Drury   David Hyndman   Yi Jin   Trevor M. Penning     184
Life without Aldose Reductase   Satish K. Srivastava   Kota V. Ramana   Aruni Bhatnagar     198
Species Comparison of AKR7A Family Members   Elizabeth M. Ellis     209
Retinoid-Active Short-Chain Dehydrogenases/Reductases   Natalia Y. Kedishvili     217
Crystal Structure of Pig Heart Carbonyl Reductase   Nobutada Tanaka   Ken-ichi Aoki   Shuhei Ishikura    Makoto Nagano   Yorishige Imamura   Akira Hara   Kazuo T. Nakamura     224
Lead Optimization in the Design of Aldose Reductase Inhibitors   Ganesaratnam K. Balendiran   Malkhey Verma   Satish Bharadwaj     231
Selective Inhibitors of AKR1C3 as Anti-Proliferative Agents   Michael C. Byrns   Trevor M. Penning     242
AKR1C1 and AKR1C3 as Potential Targets for Phytoestrogen Action   Petra Brozic   Stanislav Gobec   Tea Lanisnik Rizner     252
Searching for Inhibitors of Fungal 17[Beta]-Hydroxysteroid Dehydrogenase   Katja Kristan   Matej Sova   Mojca Lunder   Tomaz Bratkovic   Stanislav Gobec   Borut Strukelj   Jure Stojan   Jerzy Adamski   Tea Lanisnik Rizner     263
Conversion of AKR1C20 into an AKR1C6-Type Enzyme by Site-Directed Mutagenesis   Satoshi Endo   Toshiyuki Matsunaga   Kazuo Tajima   Akira Hara     273
A Comparison of Methods for Assays of Steroidogenic Enzymes: New GC/MS versus HPLC and TLC   Cornelia Prehn   Fabian Strohle   Ferdinand Haller   Brigitte Keller   Martin Hrabe de Angelis   Jerzy Adamski   Rebekka Mindnich      281
Purification of Aldo-keto Reductase AKR1B10 from Human Liver and Its Participation in the Carbonyl Reduction of Xenobiotics   Hans-Jorg Martin   Ursula Breyer-Pfaff   Simone Block   Simone Venz   Vladimir Wsol   Edmund Maser     288
Characterization of Guinea Pig Liver D-Xylulose Reductase of the Uronate Pathway: Identity with Sorbitol Dehydrogenase   Shuhei Ishikura   Toshiyuki Matsunaga   Satoshi Endo   Kengo Matsumoto   Noriyuki Usami   Ossama El-Kabbani   Akira Hara     296
Fungal Mannitol 2-Dehydrogenases and Mannitol-1-Phosphate 5-Dehydrogenases Constitute Novel Branches in the Protein Family of Polyol-Specific Long-Chain Dehydrogenases and Reductases   Bernd Nidetzky   Mario Klimacek     305
Relative Efficacy of Aldo-keto Reductases in Catalyzing the Reduction of Phospholipid Aldehydes   Matthew Spite   Oleg Barski   Yonis Ahmed   Aruni Bhatnagar   Sanjay Srivastava     323
[Delta superscript 4]-3-Ketosteroid 5[Beta]-Reductase (AKR1D1): Properties and Role in Bile Acid Synthesis   Jason E. Drury   Trevor Penning     332
Metabolism of 4-Hydroxy-trans-2-Nonenal (HNE)-Modified Proteins in Vascular Smooth Muscle Cells   Bradford G. Hill   Sanjay Srivastava   Andrew Feldman    Aruni Bhatnagar     341
Are 17[Beta]-HSDs Responsible for Increased Estradiol Concentrations within Ectopic and Cancerous Endometrium?   Tina Smuc   Katja Kristan   Gregor Bajc   Jasna Sinkovec   Martina Ribic-Pucelj   Bettina Husen   Hubert Thole   Tea Lanisnik Rizner     350
Regulation of Promoter Activity of the Aldose Reductase Gene Through the Multiple Stress Response Region, MSRR   Toru Nishinaka   Han Geuk Seo   Takeshi Miura   Tomoyuki Terada   Chihiro Yabe-Nishimura     360
Expression of Carbonyl Reductases in Fetal Human Brain, but Not in Adult   Hidetoshi Mizobuchi   Takeshi Miura   Kazutake Tsujikawa   Toru Nishinaka   Tomoyuki Terada     368
Aldose Reductase Mediates Endotoxin-induced Cardiomyopathy and Septic Shock via Reduction of Lipid Aldehydes   Kota V. Ramana   Monte S. Willis   Jureta W. Horton   Deepak Srivastava   Aruni Bhatnagar   Satish K. Srivastava     379
Modulation of Gamma-Hydroxybutyrate Induced Sleep Using Hepatic AKR7A5 and AKR1A4 Inhibitors   Elizabeth Litvinovich   Peter J. O'Brien     389
Aldose Reductase Inhibition Prevents Lipopolysaccharide-Induced NF-[Kappa]B Signaling in Human Lens Epithelial Cells    Aramati B. M. Reddy   Agnieszka Pladzyk   Umesh C. S. Yadav   Ravinder Tammali   Satish K. Srivastava   Kota V. Ramana     394
Catalytic Activity of the [Beta]-Subunits of Voltage-sensitive Potassium Channels and Its Regulation by Pyridine Nucleotides   Srinivas M. Tipparaju   Aruni Bhatnagar   Oleg A. Barski     401
Index     411

Editorial Reviews

Proceedings of the Sixth International Workshop on [title], held near Dublin, Ireland in June 1992. The volume is divided into sections covering aldehyde dehydrogenase (26 papers), aldose reductase (eight papers) carbonyl reductase (six papers), and alcohol dehydrogenase (24 papers). Site directed mutagenesis to probe for the active site of an enzyme has become part of traditional enzymology, and many of the presenters now use this tool to study some aspect of structure and function of the carbonyl metabolizing enzymes. Annotation c. Book News, Inc., Portland, OR (booknews.com)

Booknews