| Aldehyde Dehydrogenase | |
| 1. | The Big Book of Aldehyde Dehydrogenase Sequences: An Overview of the Extended Family | 1 |
| 2. | Reaction-Chemistry-Directed Sequence Alignment of Aldehyde Dehydrogenases | 9 |
| 3. | Three-Dimensional Structure of Mitochondrial Aldehyde Dehydrogenase: Mechanistic Implications | 15 |
| 4. | A Structural Explanation for the Retinal Specificity of Class 1 ALDH Enzymes Stanley A. Moore, Heather M. Baker, Treena J. Blythe, Kathryn E. Kitson | 27 |
| 5. | Structure and Function of Betaine Aldehyde Dehydrogenase: An Enzyme within the Multienzyme Aldehyde Dehydrogenase System | 39 |
| 6. | Evaluation of the Roles of the Conserved Residues of Aldehyde Dehydrogenase | 45 |
| 7. | Aldehyde Dehydrogenase Catalytic Mechanism: A Proposal | 53 |
| 8. | Inhibition of Human Mitochondrial Aldehyde Dehydrogenase by Metabolites of Disulfiram and Structural Characterization of the Enzyme Adduct by HPLC-Tandem Mass Spectrometry | 61 |
| 9. | Mechanism of Inhibition of Rat Liver Class 2 ALDH by 4-Hydroxynonenal | 71 |
| 10. | Aldehyde Inhibitors of Aldehyde Dehydrogenases | 79 |
| 11. | Covalent Modification of Sheep Liver Cytosolic Aldehyde Dehydrogenase by the Oxidative Addition of Coloured Phenoxazine, Phenothiazine and Phenazine Derivatives | 89 |
| 12. | A Thioester Analogue of an Amino Acetylenic Aldehyde Is a Suicide Inhibitor of Aldehyde Dehydrogenase and an Inducer of Apoptosis in Mouse Lymphoid Cells Overexpressing the bc12 Gene | 97 |
| 13. | Reaction between Sheep Liver Mitochondrial Aldehyde Dehydrogenase and a Chromogenic 'Reporter Group' Reagent | 107 |
| 14. | Activity of the Human Aldehyde Dehydrogenase 2 Promoter Is Influenced by the Balance between Activation by Hepatocyte Nuclear Factor 4 and Repression by Perosixome Proliferator Activated Receptor [delta], Chicken Ovalbumin Upstream Promoter-Transcription Factor, and Apolipoprotein Regulatory Protein-1 | 115 |
| 15. | [alpha],[beta]-Unsaturated Aldehydes Mediate Inducible Expression of Glutathione S-Transferase in Hepatoma Cells through Activation of the Antioxidant Response Element [ARE] | 123 |
| 16. | Effect of Arachidonic Acid Alone or with Prooxidant on Aldehyde Dehydrogenases in Hepatoma Cells | 133 |
| 17. | Prepubertal Regulation of the Rat Dioxin-Inducible Aldehyde Dehydrogenase (ALDH3) | 143 |
| 18. | Effects of Tamoxifen and Toremifene on ALDH1 and ALDH3 in Human Retinal Pigment Epithelial Cells and Rat Liver | 151 |
| 19. | Negative Regulation of Rat Hepatic Aldehyde Dehydrogenase 3 by Glucocorticoids | 159 |
| 20. | Modulation of Class 3 Aldehyde Dehydrogenase Gene Expression: An Eye Opening Experience | 165 |
| 21. | Susceptibility of Hepatoma Cells to Lipid Peroxidation and Adaptation of ALDH 3C Activity to Iron-Induced Oxidative Stress | 171 |
| 22. | The Lack of AHD4 Induction by TCDD in Corneal Cells May Involve Tissue-Specific Regulatory Proteins | 181 |
| 23. | Human Corneal and Lens Aldehyde Dehydrogenases: Localization and Function(s) of Ocular ALDH1 and ALDH3 Isozymes | 189 |
| 24. | The Role of Retinoid Metabolism by Alcohol and Aldehyde Dehydrogenases in Differentiation of Cultured Neuronal Cells | 199 |
| 25. | Metabolism of Retinaldehyde by Human Liver and Kidney | 205 |
| 26. | The Hunt for a Retinal-Specific Aldehyde Dehydrogenase in Sheep Liver | 213 |
| 27. | Cardiac Metabolism of Enals | 223 |
| 28. | Oxidation of Ethanol to Acetaldehyde in Brain and the Possible Behavioral Consequences | 231 |
| 29. | Cloning and Expression of a cDNA Encoding a Constitutively Expressed Rat Liver Cytosolic Aldehyde Dehydrogenase | 237 |
| 30. | The Roles of Acetaldehyde Dehydrogenases in Saccharomyces Cerevisiae | 243 |
| 31. | Characterization of an Aldehyde Dehydrogenase Gene Fragment from Mung Bean (Vigna radiata) Using the Polymerase Chain Reaction | 249 |
| 32. | Aldehyde Dehydrogenase Gene Superfamily: The 1998 Update | 255 |
| Alcohol Dehydrogenase | |
| 33. | Human Alcohol Dehydrogenase Family: Functional Classification, Ethanol/Retinol Metabolism, and Medical Implications | 265 |
| 34. | Dynamics in Alcohol Dehydrogenase Elucidated from Crystallographic Investigations | 275 |
| 35. | Studies on Variants of Alcohol Dehydrogenases and Its Domains | 285 |
| 36. | Uncompetitive Inhibitors of Alcohol Dehydrogenases | 295 |
| 37. | Tandem Mass Spectrometry of Alcohol Dehydrogenase and Related Biomolecules | 305 |
| 38. | Function of Alcohol Dehydrogenase and Aldehyde Dehydrogenase Gene Families in Retinoid Signaling | 311 |
| 39. | Primary Role of Alcohol Dehydrogenase Pathway in Acute Ethanol-Induced Impairment of Protein Kinase C-Dependent Signaling System | 321 |
| 40. | Class II Alcohol Dehydrogenase: A Suggested Function in Aldehyde Reduction | 331 |
| 41. | Zinc Binding Characteristics of the Synthetic Peptide Corresponding to the Structural Zinc Site of Horse Liver Alcohol Dehydrogenase | 339 |
| 42. | Amphibian Alcohol Dehydrogenase: Purification and Characterization of Classes I and III from Rana perezi | 343 |
| 43. | Extracellular Acidification: A Novel Detection System for Ligand/Receptor Interactions: Demonstration with Bioactive Peptides and CHO or Pancreatic [beta] Cells, but of Possible Interest for Tracing Putative Receptors in Ethanol Metabolism | 351 |
| Short and Medium Chain Dehydrogenase | |
| 44. | Multiplicity and Complexity of SDR and MDR Enzymes | 359 |
| 45. | Regulatory Factors and Motifs in SDR Enzymes | 365 |
| 46. | Bioinformatics in Studies of SDR and MDR Enzymes | 373 |
| 47. | The Protective Role of 11[beta]-Hydroxysteroid Dehydrogenase/Carbonyl Reductase against Tobacco-Smoke Related Lung Cancer | 379 |
| 48. | Structure-Function Relationships of 3[beta]-Hydroxysteroid Dehydrogenases Involved in Bile Acid Metabolism | 389 |
| 49. | Cloning and Sequencing of a New Comamonas testosteroni Gene Encoding 3[alpha]-Hydroxysteroid Dehydrogenase/Carbonyl Reductase | 395 |
| 50. | Comparative Properties of Three Pteridine Reductases | 403 |
| 51. | Effect of Androgen Structures on the Inhibition of Metyraponeinreductase in Rat, Mouse, and Human Liver | 411 |
| Reductases | |
| 52. | Physiological Relevance of Aldehyde Reductase and Aldose Reductase Gene Expression | 419 |
| 53. | The Aldo-Keto Reductases and Their Role in Cancer | 427 |
| 54. | Structure-Function Studies of FR-1: A Growth Factor-Inducible Aldo-Keto Reductase | 435 |
| 55. | 4-Hydroxynonenal Metabolism by Aldo/Keto Reductase in Hepatoma Cells | 445 |
| 56. | Interconversion Pathways of Aldose Reductase Induced by Thiol Compounds | 453 |
| 57. | Aldo-Keto Reductases in Norepinephrine Metabolism | 459 |
| 58. | Rotamers of Tolrestat and Their Binding Mode to Aldose Reductase | 465 |
| 59. | Stereoselective High-Affinity Reduction of Ketonic Nortriptyline Metabolites and of Ketotifen by Aldo-Keto Reductases from Human Liver | 473 |
| 60. | Formation of Lens Aldose Reductase Mixed Disulfides with GSH by UV Irradiation and Its Proteolysis by Lens Calpain | 481 |
| 61. | Inhibition of Aldose Reductase by Gossypol and Gossypol-Related Compounds | 487 |
| 62. | Inhibition of Human Aldose and Aldehyde Reductases by Non-Steroidal Anti-Inflammatory Drugs | 493 |
| 63. | Regulation of Aldose Reductase by Aldehydes and Nitric Oxide | 501 |
| 64. | The Cytotoxicity of Methylglyoxal and 3-Deoxyglucosone Is Decreased in the Aldehyde Reductase Gene-Transfected Cells | 509 |
| 65. | Enzymes Metabolizing Aldehydes in HL-60 Human Leukemic Cells | 517 |
| 66. | Rat Carbonyl Reductase: How Many Genes? | 523 |
| 67. | Cytostatic Drug Resistance: Role of Phase-I Daunorubicin Metabolism in Cancer Cells | 529 |
| 68. | Expression of mRNAs for Dihydrodiol Dehydrogenase Isoforms in Human Tissues | 539 |
| 69. | Alterations in the Expression of Daunorubicin Phase-I Metabolising Enzymes in Different Carcinoma Cell Lines | 545 |
| Index | 553 |
