Electroporation in Veterinary Oncology Practice: Electrochemotherapy and Gene Electrotransfer for Immunotherapy

by Joseph A. Impellizeri (Editor)

Overview

This is the first edited collection on veterinary applications of electroporation. Written by an international team of experts, this book presents worldwide emerging therapy options for cancer treatments in veterinary oncology practice.

Electroporation offers a precision tool to target cancer cells without destroying surrounding tissue structures. The opening of tumor cell membranes facilitates local control of solid tumors either through the delivery of chemotherapeutics or by direct ablation of tissues using electric fields. In addition, transfer of gene-based products into the cancer cells can be used for genetic vaccination to achieve systemic responses and cancer control.

Readers will discover valuable reference texts for practitioner education, including chapters on electrodes for unique anatomical access and treatment planning for deep-seated tumors, different immunotherapy applications with gene electrotransfer, calcium electroporation, irreversible electroporation applications and combinations with other common treatments such as surgery, radiation therapy and chemotherapy.

Therapy options with electroporation are gaining interest around the world in both human and veterinary oncology, making this book valuable for oncologists, surgeons, primary care veterinarians, residents, interns and students at veterinary schools, where teaching of Electrochemotherapy will become part of the curriculum. Featuring cross-disciplinary authorship, this work further contributes to advances in comparative medicine and translation research in support of the One Health concept.

Product Details

ISBN-13:	9783030806675
Publisher:	Springer International Publishing
Publication date:	11/21/2021
Edition description:	1st ed. 2021
Pages:	352
Product dimensions:	6.10(w) x 9.25(h) x (d)

About the Author

Dr. Joseph A. Impellizeri DVM, DACVIM (Oncology), MRCVS is the Chief Medical Officer of Veterinary Oncology Services, PLLC, New York, USA. after graduating from the College of Veterinary Medicine at Cornell University, Dr. Impellizeri completed a small animal medical and surgical internship at the College of Veterinary Medicine and Biological Sciences at Colorado State University. After 5 years in private practice and emergency critical care, he completed his Oncology Residency and became a Diplomate of the American College of Veterinary Internal Medicine, Sub-Specialty of Oncology. An advocate of advancing cancer treatments in pets and people, Dr. Impellizeri holds an academic position as a Visiting Scholar in the Department of Biology at Vassar College in Poughkeepsie, NY. And is a member of the Royal college of veterinary surgeons. Dr. Impellizeri created the Barrymore Center for Advanced Cancer Care specializing in U.S. based Electrogenetherapy/Electrochemotherapy comprising cancer immunotherapy and localized targeted therapies to battle cancer in pets. Dr. Impellizeri is a frequent lecturer across the globe and continues to provide consults and treatments throughout the United States.

Table of Contents

Part 1: Technology and Science of Electroporation: Fundamentals.- Electroporation: Technology and Science.- Electrodes and electric field distribution in clinical practice.- Part 2: Therapeutic Applications with Electroporation in Veterinary Oncology Practice.- Electrochemotherapy in Veterinary Oncology.- Treating Mast Cell Tumors with Electrochemotherapy.- Electrochemotherapy for the treatment of transitional cell carcinoma in dogs.- Calcium electroporation in veterinary medicine.- Irreversible Electroporation Applications.- Electrochemotherapy as a multi-modality component of cancer treatment- combinations with surgery, radiation therapy and chemotherapy.- Part 3: Gene-Electrotransfer and Immunotherapy Applications with Electroporation.- Gene Electrotransfer.- Immunotherapy Applications (Telomerase and HER2) with Gene Electrotransfer.- Interleukin-12 gene electrotransfer in veterinary oncology.- Canine Melanoma and Osteosarcoma Immunotherapy by means of in vivo DNA Electroporation.-Part 4: Evolution of the Field and New Applications with Electroporation-Based Treatments: Outlook.- Electrodes for Unique Anatomical Access in Electroporation.- New Electrodes and Treatment Planning for deep-seated and intraluminal localized tumors.- Advancing Electroporation Systems.

Editorial Reviews

Reviewer: Alycen P Lundberg, DVM, DACVIM (University of Illinois at Urbana-Champaign)
Description: This textbook covers in detail the basic science of electroporation and the applications of this treatment modality in veterinary medicine. It utilizes many graphics to help the readers visualize how these treatments work.
Purpose: The purpose of the book is to provide an in-depth and thorough review of the history and science of electroporation, as well as a comprehensive summary of how electroporation is being utilized in the veterinary field. The author describes a desire to provide readers with "the past, present, and future" of electroporation and does this well. This information, compiled nicely into one textbook for veterinary medicine, is currently missing in the literature, so this textbook fills an important void. The historical component of electroporation is delivered well, and the rest of the textbook, which looks at current and future treatment potentials, is thorough and well referenced.
Audience: According to the author, this book is directed at those who are interested in the past, present, and future of electroporation therapy and can appeal to a wide range of readers. From a reader's perspective, this textbook targets those who are interested in the basic science and development of electroporation, and also those who practice veterinary medicine and want to have a better understanding of how to use electroporation for the treatment of cancer. This textbook can be very helpful to veterinary students who are interested in learning more about this technique. It is likely going to be most helpful to specialists who treat cancer patients such as medical oncologists and radiation oncologists and residents who are training for those specialties. It will be helpful to those in surgery and diagnostic imaging as well. The author and contributors are qualified and credible to be contributing to this textbook based on their experience and expertise in the field.
Features: The textbook starts by detailing how the technology was developed and became a part of clinical practice. Subsequent chapters outline specific tumor types (such as mast cell tumors, transitional cell carcinomas, etc.) and how they can be treated with electroporation. There is good detail on how this technology can be used in combination with other treatment types, including surgery, radiation, and chemotherapy. There is a section dedicated to the application of gene transfer and immunotherapy with electroporation, and then a summary for what future applications of electroporation may look like. All of the sections utilize graphics to help the readers better understand how this technology works, which adds significant value to the textbook and makes the material easy to understand, especially for visual learners.
Assessment: This book is very well written and can appeal to a large audience - those who are interested in learning the basics and the science of it, and those who are in practice and want to better understand this treatment modality to apply to their oncologic practice. There are no comparable textbooks available in veterinary medicine, so this textbook fills a void in the field.

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