Early Vascular Aging (EVA): New Directions in Cardiovascular Protection

by Michael Hecht Olsen MD, PhD (Editor), Peter M Nilsson MD, PhD (Editor), Stephane Laurent MD, PhD (Editor)

Overview

Early Vascular Aging (EVA): New Directions in Cardiovascular Protection brings together the last decade of research related to the characterization of EVA, as well as the predictive power of pulse wave velocity (PWV).

The book presents a novel approach to the problem of cardiovascular disease, showing it in relation to great vessels disease and revealing a comprehensive approach to the problem of increased rigidity of the great vessels, its causes, and further consequences.

Information provided is accompanied by online access to a supplemental website with video clips of anatomic specimens, cardiac imaging, and surgical procedures.

• Introduces the latest information on early vascular aging (EVA), complete with summaries of recent evidence and guidelines for relevant risk factor control
• Ideal reference for the study of vascular aging, pulse wave velocity, arteriosclerosis, EVA, arterial stiffness, vascular, PWV biomarkers, and cardiovascular disease
• Contains all the relevant information available from different fields of knowledge (from basic biology to epidemiology) in regard to EVA
• Provides evidence that leads to a new target for interventions, early vascular aging (EVA) in subjects with early onset increased arterial stiffness
• Includes online access to a supplemental website with video clips of anatomic specimens, cardiac imaging, and surgical procedures

Product Details

ISBN-13:	9780128016763
Publisher:	Elsevier Science
Publication date:	08/06/2015
Sold by:	Barnes & Noble
Format:	eBook
Pages:	376
File size:	12 MB
Note:	This product may take a few minutes to download.

About the Author

Michael Hecht Olsen is a professor in Hypertension and Cardiovascular Prevention at the Department for Regional Health Research, University of Southern Denmark, and senior consultant in cardiology at Department of Medicine 1, Holbaek Hospital, Denmark.

Both clinically and in research, he works with hypertension, obesity, diabetes and cardiovascular risk stratification using measurements of subclinical cardiovascular damage (e.g., pulse wave analysis, ultrasound of the carotid arteries and echocardiography) and new biomarkers for deep phenotyping trying to develop individualized treatment. He has published over 200 publications (Web of Science H-index 47).

Peter M. Nilsson is Senior Professor/expert in Clinical Cardiovascular Research at Lund University, Department of Clinical Sciences, Skåne University Hospital, Malmö, Sweden. For many years he has been developing the concept of EVA with numerous colleagues and the prevention of cardiovascular disease and type 2 diabetes.

Stepane Laurent’s research interests are hypertension pathophysiology and management, pharmacology of antihypertensive drugs, arterial stiffness and vascular ageing. He has served as President of the European Society of Hypertension (ESH) (2007-2009) and President of the ARTERY Society (2010-2012), and is the author of over 500 referenced articles and 20 chapters in books.

Table of Contents

Chapter 1: Historical Aspects and Biology of Aging
Chapter 2: Cellular and Molecular Determinant of Arterial Aging
Chapter 3: Changing Demography of Europe-Greying Populations
Chapter 4: Population-Based Studies
Chapter 5: Lessons from Amsterdam Growth and Health Longitudinal Study
Chapter 6: History and Findings of the BLSA
Chapter 7: Changes in Peripheral Blood Pressure with Normal and Accelerated Aging
Chapter 8: Changes in Arterial Stiffness with Normal and Accelerated Aging
Chapter 9: Changes in Central Hemodynamics, Wave Reflection and Heart-Vessel Coupling with Normal and Accelerated Aging
Chapter 10: Early Aging of Endothelial Function and Platelet-Vessel Wall Interaction
Chapter 11: The Cross-Talk between the Macro and Microcirculation
Chapter 12: Blood Pressure Variability
Chapter 13: Early Vascular Aging in Children with Low Birth Weight and/or Prematurity
Chapter 14: Age-Induced Endothelial Dysfunction and Intima-Media Thickening
Chapter 15: Glucose Metabolism, Diabetes, and the Arterial Wall
Chapter 16: Chronic Inflammation and Antherosclerosis
Chapter 17: Early and Late Stages of Chronic Kidney Disease in relation to Arterial Changes
Chapter 18: Polycystic Ovarian Syndrome
Chapter 19: Early and Late Stages of Brain Damage
Chapter 20: Telomere Biology and Aging
Chapter 21: Traditional versus new models of Risk Prediction
Chapter 22: Imaging Biomarkers: Aortic Stiffness and Carotid IMT as Predictors of CV Disease
Chapter 23: Genetic Markers in Prediction of CV Disease
Chapter 24: Vascular Aging and CV Disease
Chapter 25: Lifestyle Intervention: What works?
Chapter 26: Targeting BP Lowering and Sympathetic Nervous System
Chapter 27: Targeting Central BP through the Macro-Microcirculation Cross-Talk
Chapter 28: Treatment of Abnormalities in Glucose and Lipid Metabolism
Chapter 29: New Drugs under Development for Cardiovascular Prevention
Chapter 30: Interventions to retard Biological Aging to be Explored
Chapter 31: Immuniziation, Vaccines and Immunomodulation

What People are Saying About This

From the Publisher

A comprehensive look at early vascular aging (EVA), its link to arterial stiffness, and other age-related changes in the vascular tree

Editorial Reviews

"... it builds on the evidence in previous chapters, eventually signing off with a discussion of possible means to retard vascular aging...a good start on the expanding field of EVA. Score: 82 - 3 Stars" —Doody's

From the Publisher

Reviewer: Ravi Prasad Avati Nanjundappa, MD, MPH, FACP (Ochsner Clinic Foundation)
Description: Early vascular aging (EVA) is an important developing concept in cardiovascular research that was initially coined in 2008. This is a review of the current literature on the process of vascular aging and innumerable trials evaluating the risk factors and clinical outcomes.
Purpose: This book attempts to summarize the current understanding of vascular health and factors influencing premature stiffness (aging). Historically, augmentation index and pulse wave velocity have been used as surrogates for arterial stiffness. The authors describe in depth the physiological and pathological aging process and modifiable and nonmodifiable risk factors.
Audience: The intended audience is not only house staff, but practicing internists and cardiologists/vascular biologists who can use it as a tool for advancing science and research, but also to help in patient care. The three authors are reputed research scientists with over 1,000 publications to their credit collectively with contributions from over 50 international experts in the field.
Features: Vascular aging has been identified as an emerging cardiovascular risk factor. There is clearly no definite point that distinguishes "normal" and "early" vascular aging. This book initiates the discussion with a review of the concept of vascular aging at the molecular and cellular level, the structural and functional changes occur in the large arteries with aging. Endothelial dysfunction is a key component of vascular aging and clinical risk factors influencing it are described in depth. Blood pressure as a key surrogate for a marker of vascular health is analyzed extensively (both central and peripheral), and micro and macro circulatory complications in the presence of uncontrolled blood pressure. Vascular changes associated with glucose metabolism and chronic kidney diseases are described as well. Due to the complex nature of age-associated changes in the large arteries, there are different parameters relating to vascular aging that can be measured objectively. These broadly include aortic and carotid stiffening, aortic and carotid lumen dilation, endothelial dysfunction (usually measured via brachial flow-mediated dilatation), and carotid intima-media thickness. Noninvasive imaging studies are of great use in evaluating these. The format of the book is such that it builds on the evidence in previous chapters, eventually signing off with a discussion of possible means to retard vascular aging.
Assessment: This is a good start on the expanding field of EVA.

Doody's Review Service