Early Life Origins of Ageing and Longevity

by Alexander Vaiserman

Overview

This book provides a comprehensive overview of the field of developmental programming of ageing phenotypes. Although gerontological research has traditionally focused on later stages of the life cycle, growing evidence indicates that both the rate of ageing-associated functional declines, and the risks of later-life chronic pathological conditions, can be traced to origins early in life.

While other books in the field concentrate on the developmental origin of particular disorders, this volume offers a detailed guide to all important aspects of the role of early-life conditions in programming both chronic pathological conditions and the ageing process.

Interest in the study of ageing and longevity had its beginnings in research on the fetal origins of adult disease. This has evolved into a hypothesis on the Developmental Origins of Adult Health and Disease (DOHaD), which postulates that adverse environmental exposures during critical in-utero and early postnatal stages of development may permanently change physiological responses and cause functional impairments and disorders in adult life.

In this book, the contributing authors and leading experts from around the world, describe research on mechanisms underlying the developmental programming phenomenon, as well as interventional strategies aimed at restoring developmentally disrupted epigenetic patterns.

Early Life Origins of Ageing and Longevity benefits a wide audience of working scientists, clinicians, and advanced students, and will also interest scientifically curious general readers who wish to know more about current research in this rapidly evolving field.

Product Details

ISBN-13:	9783030249571
Publisher:	Springer International Publishing
Publication date:	07/29/2019
Series:	Healthy Ageing and Longevity , #9
Edition description:	1st ed. 2019
Pages:	310
Product dimensions:	6.10(w) x 9.25(h) x (d)

About the Author

Alexander Vaiserman was born in Kyiv, Ukraine, in 1957. His research interests comprise epigenetics, epidemiology and experimental gerontology. He earned his MSc Degree in cytology and developmental biology from Kyiv State University in 1984, and his DSc degrees in normal physiology from Instiute of Gerontology (Kyiv, Ukraine) in 1991 and 2004, respectively. Since 1978, he has had a permanent position in the Instiute of Gerontology (Kyiv, Ukraine). Since 2010 to present hi is the head of the Laboratory of Epigenetics in the Instiute of Gerontology (Kyiv, Ukraine). He is the member of the Editorial Boards of the journals Biogerontology, Frontiers in Genetics of Aging, Journal of Genomic Medicine and Pharmacogenomics, and Journal of Gerontology & Geriatric Research.

Table of Contents

SECTION I OVERVIEW.- Introductory chapter.- SECTION II EXPERIMENTAL STUDY OF DOHAD.- Early Life Programming of Aging in Genetically Long-Lived Mice.- Immunological Basis of In Utero Programming of Adult Disease.- Developmental Programming of the GH/IGF Axis and Long Term Health.- Programming of Stress Responses.- Early-life Nutritional Programming of Adult Health Status.- Effects of In-Utero Conditions on Adult Feeding Preferences.- IUGR-Related Programming of Metabolic Syndrome and Type 2 Diabetes.- Early-life Programming of Osteoporosis.- Developmental Epigenetic Programming of Skeletal Muscle Aging.- Effect of fetal and child health on kidney development and long-term risk of hypertension and kidney disease..- Developmental Programming of Neuroimmune Function.- Epigenetics and neurodegeneration: role of early-life nutrition.- SECTION III EPIDEMIOLOGICAL EVIDENCE.- Prenatal Undernutrition and Ageing and Longevity.- Influence of Maternal Obesity on the Long-Term Healthof Offspring.- Early Life Predictors of Women's Health and Ageing.- Early-Life Predictors of Exceptional Longevity.- Prenatal Undernutrition and Effects on Physical and Mental Health.- Ancestral and early origins of adult mortality - a multigenerational approach.- SECTION IV PERSPECTIVES AND IMPLICATIONS.- Social Policy and Public Health Perspectives of DOHaD: Implications for Policy Advocacy, Cross-Sectorial Collaboration and Health Promotion.- Index.

Editorial Reviews

Reviewer: Luis F Escobar, MD, MS (Peyton Manning Children's Hospital)
Description: Part of the Healthy Ageing and Longevity series, this volume discusses epigenetic mechanisms that may affect aging and adult health. It is evidence of how current and fast-moving advances in human genetics open doors to other relevant subjects.
Purpose: In general, books in this series cover topics related to the issues of adult health. This volume intends to discuss how gerontology may turn to early stages of human gestation to understand the epigenetic effects on adult health. It details information about how early human life and environmental interactions may affect subsequent adult-onset disorders, therefore affecting human longevity. The book includes theoretical and evidence-based information and describe possible interventions to enhance health and longevity. This is a unique and stimulating book. The author and contributors have accomplished their goals well.
Audience: Aging and adult health has been the domain of gerontologists. Individuals involved in adult patient care and those involved in developing appropriate interventions early in life to prevent adult disease are a clear target audience for this book. The information is relevant for epidemiologists, professional scientists, clinicians, and, as the author indicates, scientifically interested amateurs seeking knowledge about aging and adult health. Perhaps even medical specialists in areas such as perinatology, maternal-fetal medicine, and neonatology would benefit from learning the effects of early life changes on adult health.
Features: This is a thought-provoking book. It is difficult not to get interested. The 15 chapters are divided in four sections including an overview, experimental studies, epidemiological data, and perspectives and implications of current knowledge about early factors that may affect adult health. I was particularly interested in chapter 11 on the influence of maternal obesity on the long-term health of the children. The data presented is fascinating. The chapter on prenatal exposure to famine and the link to adult pathology and neurological function is outstanding.
Assessment: The author presents the work of outstanding individuals who tackle the new and rapidly advancing knowledge about epigenetics and aging. This is a unique book with no true comparisons. Kudos to the editor and the contributors for a job well done.

Doody's Review Service

This book is not only concerned with ageing but more generally with adult health. This is an important topic and there are now many studies showing that improving health, particularly at old age, requires looking into what happened since the conception and even to what happened to the parents. … this book is particularly helpful for biogerontologists, but also for nutritionists and other physicians.” (Éric Le Bourg, Biogerontology, September 09, 2019)

From the Publisher