| Bruce Gordon | Frank Nitti |
| Charles McGraw | Holly Westra |
| Don Gordon | John Cropsey |
| Ed Nelson | Marty Pulaski |
| J.D. Cannon | Al Remp |
| Jack Klugman | Sollie Girsh |
| Jeremy Slate | Roy Dahlgren |
| John Larkin | Lt. Phillip Hedden |
| Joseph Schildkraut | Dr. Hans Frolick |
| Kathleen Nolan | Bunny Kagan |
| Pat Hingle | Barney Retzik, alias Barney Howell |
| Patricia Owens | Marcie Devon |
| Paul Richards | Lou Sultan |
| Rip Torn | Johnny Meizo |
| Robert Redford | Jackson Emmett Parker |
| Simon Oakland | Russ Bogan |
| Barry Morse | Larry Bass |
| Claude Akins | Vince Majeski |
| Dane Clark | Dr. Victor Garr |
| Frank Sutton | Sgt. Davey McCain |
| Harold J. Stone | Jules Flack |
| Joe de Santis | Victor Salazar,Janos "Jake" Szabo,Spencer |
| John Anderson | Victor Kurtz |
| Karl Lukas | Janos |
| Peter Whitney | Fat Augie Strom |
| Robert Duvall | Eddie Moon |
| Robert Emhardt | Sal Rudin |
| Robert Vaughn | Charlie Argos |
| Roy Thinnes | Red Thomas |
| Sherwood Price | Herbie Pulaski |
| Tom Tully | Danny Mundt |
| Christopher Dark | Arno Beale |
| Edward Binns | Dr. Samuels,Steve Ballard |
| Francine York | Megan Morris |
| Gail Kobe | Rita |
| George Voskovec | Charley Tarasovich |
| Gerald Hiken | Benny Angel |
| Jacqueline Scott | Lorna Shaw |
| Jeanne Cooper | Mrs. Belle Alpine |
| Jerry Fujikawa | Yang |
| John Gabriel | Dr. Daniel Gifford |
| Peggy Ann Garner | Mrs. Sultan (Barbara Monte) |
| Salome Jens | Marcy Remp |
| Tim Considine | Arnie Meizo |
| Will Kuluva | Ray "Goose" Gander |
| Barney Phillips | Otto Schuster |
| Cliff Carnell | Wally |
| Eddie Firestone | Bitsey Whyller |
| Ford Rainey | Lt. Roy Gunther |
| Frank Wilcox | D.A. Asbury |
| Gilbert Green | Kurt Koenig |
| Joan Chambers | Rosie |
| John Milford | Burt Engle |
| Johnny Seven | Murray Alpine |
| Kent Smith | Eli Harmon |
| Liam Sullivan | Dr. Jarvis |
| Marc Lawrence | Lew Kagan |
| Peter Hansen | Prof. Harry Farris |
| Robert Yuro | Dino |
| Torin Thatcher | Ed Monte |
| Virginia Christine | Doris Meizo |
| Grace Lee Whitney | Fran |
| H.M. Wynant | Boley Davis |
| I. Stanford Jolley | Pete Laffey |
| James Griffith | Monk Lyselle |
| Joe Turkel | Eddie "Deuces" Kobler |
| Joseph Ruskin | Lepke Buchalter |
| Joyce Van Patten | Claire Vale |
| Michael Constantine | Max Frivol |
| Patty Regan | Patsy |
| Phillip Pine | Whitey Grosse |
| Raymond Guth | Marrie |
| Robert Doyle | Jimmy Farris |
| Stefan Gierasch | Gil Kellerman |
| Steven Geray | Karl Reising |
| Woodrow Parfrey | Ferris |
Technical Credits
| Alex March | Director |
| Allen Reisner | Director |
| Ida Lupino | Director |
| Laslo Benedek | Director |
| Leonard Horn | Director |
| Paul Wendkos | Director |
| Robert Butler | Director |
| Robert Gist | Director |
| Sherman Marks | Director |
| Vincent McEveety | Director |
| Walter E. Grauman | Director |