No one knows what evil lurks with the folks next door in this black comedy. Earl Keese (John Belushi) is a middle-aged suburbanite whose life is dull and uneventful, and that's just the way he likes it, though his wife, Enid (Kathryn Walker), isn't quite so happy. Earl soon learns that a new couple has just moved into the house next door, loudly leisure-suited Vic (Dan Aykroyd) and sexy Ramona (Cathy Moriarty). Earl is at once thrilled and terrified when Ramona unexpectedly attempts to seduce him, and he is quite puzzled when Vic and Ramona stop by for dinner the following evening and Ramona angrily accuses Earl of trying to take advantage of her. After an argument, Vic offers to make peace by buying dinner from a take-out restaurant. When Earl spies Vic cooking the meal in his kitchen a few minutes later, he realizes that his new neighbors are playing some sort of game with him, though he's not sure what or why. Neighbors marked the third and final screen pairing of Saturday Night Live stars John Belushi and Dan Aykroyd; Belushi died of a drug overdose three months after the film's release.