Guy Madison and Rory Calhoun, both of whom went on to star in their own TV western series, head the cast of the Monogram sagebrusher Massacre River. Madison and Calhoun play Larry Knight and Phil Acton, fellow Army officers and rivals for the attentions of colonel's daughter Kitty Reid (Cathy Downs). Losing the romantic battle, Knight loses himself in the arms of no-good gambling-hall proprietress Laura Jordan (Carole Mathews). All amorous intrigues are forgotten when Knight and Acton fight shoulder to shoulder against marauding Indians. To ensure better bookings, Monogram released Massacre River through its "prestige" subsidiary Allied Artists.