| Meryl Streep | Donna,Jane,Kate Gulden,Lisa Metzger |
| Pierce Brosnan | Sam |
| Renée Zellweger | Ellen Gulden |
| Steve Martin | Adam |
| Uma Thurman | Rafi Gardet |
| Alec Baldwin | Jake |
| Bryan Greenberg | David Bloomberg |
| Colin Firth | Harry |
| William Hurt | George Gulden |
| Jon Abrahams | Morris |
| Lake Bell | Agness |
| Stellan Skarsgård | Bill |
| Tom Everett Scott | Brian Gulden |
| John Krasinski | Harley |
| Julie Walters | Rosie |
| Lauren Graham | Jules |
| Zak Orth | Randall |
Technical Credits
| Ben Younger | Director |
| Carl Franklin | Director |
| Nancy Meyers | Director |
| Phyllida Lloyd | Director |
