| Leonardo DiCaprio | Billy Costigan,Howard Hughes |
| Robert De Niro | James Conway |
| Cate Blanchett | Katharine Hepburn |
| Matt Damon | Colin Sullivan |
| Ray Liotta | Henry Hill |
| Jack Nicholson | Frank Costello |
| Joe Pesci | Tommy DeVito |
| Kate Beckinsale | Ava Gardner |
| John C. Reilly | Noah Dietrich |
| Lorraine Bracco | Karen Hill |
| Mark Wahlberg | Sergeant Dignam |
| Alec Baldwin | Juan Trippe |
| Martin Sheen | Captain Queenan |
| Paul Sorvino | Paul Cicero |
| Alan Alda | Sen. Ralph Owen Brewster |
Technical Credits
| Martin Scorsese | Director |
