| Vin Diesel | Ray Garrison / Bloodshot |
| Eiza González | Actor |
| Sam Heughan | Corporal Harlan 'So Long' Shifflet |
| Toby Kebbell | Axe |
| Talulah Riley | Actor |
| Lamorne Morris | Wilfred Wigans |
| Guy Pearce | Actor |
| Jóhannes Haukur Jóhannesson | Nick Baris |
| Alex Hernandez | Actor |
| Siddharth Dhananjay | Eric |
| Tamer Burjaq | Mombasa Gunman |
| Patrick Kerton | Truck Driver |
| Ryan Kruger | British Man |
| Alex Anlos | Barris Merc |
| Maarten Romer | Tech |
| Jeremy Boado | Tech #2 |
| Clyde Berning | Mombasa Hostage |
| Tyrel Meyer | Merc 2 |
| Michael Kirch | German Man |
Technical Credits
| David S.F. Wilson | Director |
| Alex Anlos | Casting |
| Matt Antoun | Executive Producer |
| Bonnie Lee Bouman | Casting |
| Anton Brand | Animator |
| Stephanie Clerkin | Set Decoration/Design |
| Dan Mintz | Executive Producer |
| Vin Diesel | Producer |
| Nick Erdos | Animator |
| Maurice Fadida | Executive Producer |
| Louis G. Friedman | Executive Producer |
| Diana Grande | Animator |
| Jonathan Gray | Executive Producer |
| Yvel Guichet | Original Story |
| Eric Heisserer | Screenwriter |
| Brett Hirson | Set Decoration/Design |
| Steve Jablonsky | Score Composer |
| Toby Jaffe | Producer |
| Jacques Jouffret | Cinematographer |
| Jason Kothari | Executive Producer |
| Vincent Lascoumes | Asst. Director |
| Bob Layton | Original Story |
| Marike Liebetrau | Makeup |
| Nico Louw | Sound Mixer |
| Steve Matzkin | Executive Producer |
| Jim May | Editor |
| Celene McDowell | Set Decoration/Design |
| Moray McGregor | Art Director |
| Aaron McGriff | Animator |
| Cordell McQueen | Special Effects Supervisor |
| David Mimran | Executive Producer |
| Neal H. Moritz | Producer |
| John Papsidera | Casting |
| Buddy Patrick | Executive Producer |
| Don Perlin | Original Story |
| Stewart Probert | Production Manager |
| Jim Raubenheimer | Makeup |
| Matthew Rhodes | Executive Producer |
| Sarah Schroeder-Matzkin | Executive Producer |
| Jordan Schur | Executive Producer |
| Dinesh Shamdasani | Producer |
| Mark Strome | Executive Producer |
| Tyler Thompson | Executive Producer |
| Kimberly A. Tillman | Costumes/Costume Designer |
| Tom Brown | Production Designer |
| Kevin VanHook | Original Story |
| Jeff Wadlow | Original Story,Screenwriter |