Drugs and Poisons in Humans: A Handbook of Practical Analysis / Edition 1

by Osamu Suzuki, Kanako Watanabe

Overview

Unique analysis of drugs and poisons to facilitate testing in all laboratories even by inexperienced chemists

Includes source of chemicals needed for the experiments

Texts are composed by 67 experts in analyzing the respective compounds

Clear and uniform structure of chapters for ease of reading

The text is illustrated by many diagrams and tables

Product Details

ISBN-13:	9783642060878
Publisher:	Springer Berlin Heidelberg
Publication date:	12/16/2010
Edition description:	Softcover reprint of hardcover 1st ed. 2005
Pages:	672
Product dimensions:	6.10(w) x 9.25(h) x 0.05(d)

Table of Contents

Chapters of general nature 1) How to handle biological specimens 2) Alternative specimens 3) Pitfalls and cautions in analysis of drugs and poisons 4) Pretreatments of human specimens 5) Detection methods 6) A computer system for diagnosis of causative drugs and poisons developed by the Japan Poison Information Center (Tokyo) 7) Practical use of the poison-net developed by the Japan Poison Information Network (Hiroshima) 8) Problems in toxin analysis in emergency medicine 9) Analyses of chemical weapons and their related compounds Chapters on specific toxins 1. Volatile compounds 1) Carbon monoxide 2) Hydrogen sulfide and its metabolites 3) Cyanide 4) Methanol and formic acid 5) Ethanol 6) Chloroform and dichloromethane 7) Toluene, benzene, xylene and stylene 8) Alkyl nitrites 9) Compenents of gasoline and kerosene 2. Controlled drugs 1) Amphetamines and their metabolites 2) Cannabinoids and their metabolites 3) Morphine and its analogues 4) Cocaine and its metabolites 5) Pentazocine 6) Lysergic acid diethylamide (LSD) 7) 3,4-Methylenedioxyamphetamines 8) Phencyclidine 9)—- Hydroxybutyric acid 3. Psychopharmaceuticals and hypnotics 1) Phenothiazines 2) Butyrophenones 3) Tricyclic and tetracyclic antidepressants 4) Benzodiazepines 5) Bromisovalum 6) Barbiturates 4. General drugs 1) Diphenylmethane antihistaminics 2) Propionic acid derivative analgesic-antipyretics 3) Acetaminophen (paracetamol) 4) Acetylsalicylic acid 5) Antiepileptics 6) Muscle relaxants 7) ß- Blockers 8) Local anaesthetics 9) Salicylicacid 10) ß- Lactam antibiotics 5. Chemicals of daily necessaries 1) Hypochlorite 2) Benzalkonium chlorides 3) Hair dyes 4) Permethrin 5) Boric acid 6) Naphthalene 7) p-Dichlorobenzene 8) Ethylene glycol 6. Natural toxins and alkaloids 1) Aconite toxins 2) Mushroom toxins 3) Tetrodotoxin 4) Methylxanthine derivatives 5) Nicotine and cotinine 6) Tropane alkaloids 7) Oleander toxins 7. Pesticides 1) Simultaneous analysis of pesticides by GC/MS 2) Organophosphorus pesticides 3) Glufosinate and glyphosate 4) Carbamate pesticides 5) Paraquat and diquat 6) Cresol 7) Diazine and triazine herbicides 8) Coumarin rodenticides 8. Miscellaneous 1) Sarin and its decomposition products 2) VX and its decomposition products 3) Sodium azide 4) Arsenic compounds and other inorganic poisons 5) Nitrate and nitrite compounds 6) Methemoglobin

Editorial Reviews

4 Stars! from Doody

Reviewer: Laura Ann Spivak, BA, MD (Oregon Health and Science University)
Description: This is an updated, English translation of a handbook, originally published in Japanese in 2002, that was designed to provide the most reliable and reproducible methods for drug analysis. Each chapter is authored by an expert in the specific drug being discussed.
Purpose: The purpose is to provide analytical chemists with a comprehensive array of modalities to measure xenobiotics and metabolites in biological matrices. This book is unique in that it addresses a wide spectrum of analytes and metabolites in a single manual, and highlights important points with diagrams, algorithms, and pertinent case studies. The book is successful in meeting the authors' objectives.
Audience: It is aimed at analytical chemists, but may also be useful for professionals engaged in the fields of toxicology and forensic laboratory science, such as forensic toxicologists. The authors are nationally recognized Japanese scientists, and they have included contributions from other Japanese specialists within their field.
Features: The book covers a wide range of drugs and discusses the various methodologies for analysis. Introductory chapters detail other related topics, such as the handling of biologic specimens, pitfalls in drug analysis, and analysis of chemical warfare agents. It is well-organized, and presents information in a standardized format, supplemented with graphs and illustrations. The one shortcoming of this book is the translation. Although concepts are not obscured by poor grammar and sentence structure, it does present the reader with some difficulty.
Assessment: The book is a concise, well-organized compendium of practical analytical methodologies for drug analysis. It is extremely useful for practitioners in the field of analytical chemistry, and provides many valuable points regarding laboratory methodology and forensic analysis of drug distribution. Extra chapters are added to provide information relevant to an international audience. The only problem with this handbook in comparison with other books in the field is the poor translation. As I mentioned, this does not hinder the communication of important concepts, but does create a rather cumbersome reading experience.

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