Drug Metabolism: Chemical and Enzymatic Aspects

by Jack P. Uetrecht, William Trager

Overview

In order to understand drug metabolism at its most fundamental level, pharmaceutical scientists must be able to analyze drug compound structure and predict possible metabolic pathways in order to avoid the risk of adverse reactions that lead to the withdrawal of a drug from the market. This title is a comprehensive guide for recognizing the chemical underpinnings of drug metabolism. While there are numerous resources available to medicinal chemists for understanding drug structure, and to pharmacologists for discerning drug metabolism from a biological standpoint, no resource currently exists that links the chemical and biological aspects in language accessible to both-making it challenging for both groups to fully comprehend how a drug is metabolized, as well as the potential effects of the metabolites. Drug Metabolism: Chemical and Enzymatic Aspects provides extensive material to help understand drug metabolism within a biological context, and for predicting and mitigating adverse drug reactions.

Product Details

ISBN-13:	9780367453022
Publisher:	CRC Press
Publication date:	12/18/2020
Pages:	179
Product dimensions:	7.00(w) x 10.00(h) x (d)

About the Author

Uetrecht, Jack P. | Trager, William

Table of Contents

Preface iii

1 Introduction 1

2 Background for Noncheraists 4

3 Background for Chemists 18

4 Oxidation Pathways and the Enzymes That Mediate Them 33

5 Reductive Pathways 109

6 Hydrolytic Pathways 120

7 Conjugation Pathways 130

8 Reactive Metabolites 145

Index 167