Drug Delivery: Engineering Principles for Drug Therapy

by W. Mark Saltzman

Overview

Synthetic materials are a tremendous potential resource for treating human disease. For the rational design of many of these biomaterials it is necessary to have an understanding of polymer chemistry and polymer physics. Equally important to those two fields is a quantitative understanding of the principles that govern rates of drug transport, reaction, and disappearance in physiological and pathological situations. This book is a synthesis of these principles, providing a working foundation for those in the field of drug delivery. It covers advanced drug delivery and contemporary biomaterials.

Product Details

ISBN-13:	9780199879755
Publisher:	Oxford University Press
Publication date:	03/15/2001
Series:	Topics in Chemical Engineering
Sold by:	Barnes & Noble
Format:	eBook
File size:	31 MB
Note:	This product may take a few minutes to download.

Table of Contents

Part I. Introductory material1. Introduction2. Drug administration and drug effectivenessPart II. Fundamentals3. Diffusion and drug dispersion4. Diffusion in biological systems5. Drug permeation through biological barriers6. Drug transport by fluid motion7. Pharmacokinetics of drug distributionPart III. Drug delivery systems8. Drug modification9. Controlled drug delivery systems10. Case studies in drug delivery11. PostscriptAppendix A. Overview of polymeric biomaterialsA1. Nondegradable polymersA2. Biodegradable polymersA3. Water-soluble polymersAppendix B. Useful data and nomenclatureB1. Physiological parametersB2. Cardiovascular systemB3. Clinical chemistryB4. Permeation and diffusionB5. Protein propertiesB6. Mathematical tables and functionsB7. NomenclatureIndex

Editorial Reviews

"Providing a working foundation in the principles underlying drug transport, reaction, and disappearance in physiological and pathological situations, this introduction and guide covers a range of topics, including drug and protein properties, drug modification and diffusion, and polymeric biomaterials. Case studies, physiological guidelines, and useful nomenclature and data are also featured. Saltzman teaches chemical engineering at Cornell University."—SciTech Book News

"[A]n excellent addition to the library of any scientist interested in drug delivery systems. Unlike others in the area, this volume is focused on quantitative understanding of the principles that govern rates of drug transport, reaction, and disappearance in physiological conditions. ... even a scientist who may lack a background in mathematics could benefit from this unique discussion of engineering concepts. ... what makes this book outstanding is the ability of the author to discus mathematical equations grounded in real examples. ... The book is highly recommended as a textbook in the field of drug delivery ..."—The Quarterly Review of Biology

From the Publisher