DNA Modifications in the Brain: Neuroepigenetic Regulation of Gene Expression

by Timothy W Bredy

Overview

DNA Modifications in the Brain: Neuroepigenetic Regulation of Gene Expression begins with an historical overview of the early discoveries surrounding DNA methylation in the mammalian brain and then explores the evidence supporting a role for this epigenetic mechanism in controlling gene expression programs across the lifespan in both normal and diseased states.

Chapters describe new directions and technological advances, and provide an overview of what the future holds for this exciting new field. This book is ideal for medical, graduate and advanced undergraduate students, but is also a great resource for researchers who need a broad introduction to the dynamic nature of DNA that sheds light on evolving concepts of gene-environment interaction and their effects on adaptation and neuropsychiatric disease.

Product Details

ISBN-13:	9780128015964
Publisher:	Elsevier Science
Publication date:	01/05/2017
Pages:	180
Product dimensions:	7.50(w) x 9.25(h) x (d)

About the Author

Dr. Timothy Bredy is Associate Professor of Neuroscience in the Ayala School of Biological Sciences at the University of California Irvine and Senior Research Fellow within the Queensland Brain Institute at the University of Queensland.

Table of Contents

1. History and Modern View on DNA Modifications in the Brain 2. Approaches to Detecting DNA Base Modification in the Brain 3. Active DNA Demethylation in Neurodevelopment 4. TET and 5hmC in Neurodevelopment and the Adult Brain 5. Beyond mCG: DNA Methylation in Noncanonical Sequence Context 6. DNA Modifications and Memory 7. Measuring CpG Methylation by SMRT Sequencing 8. Epigenetic Modifications of DNA and Drug Addiction 9. What Does the Future Hold for the Study of Nucleic Acid Modifications in the Brain?

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From the Publisher

A comprehensive reference on the role of the epigenome in gene expression and brain function in both normal and diseased states